ChemicalBook >> CAS DataBase List >>TP-3654
TP-3654
- CAS No.
- 1361951-15-6
- Chemical Name:
- TP-3654
- Synonyms
- Nuvisertib;TP3654;CS-2702;TP-3654;TP-3654 ，S6774;TP3654 ;TP 3654;TP-3654, 10 mM in DMSO;TP3654,inhibit,Pim,TP 3654,Pim kinases,Inhibitor,TP-3654;2-(trans-4-((3-(3-(Trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol;2-((1r,4r)-4-((3-(3-(Trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol
- CBNumber:
- CB93049508
- Molecular Formula:
- C22H25F3N4O
- Molecular Weight:
- 418.46
- MDL Number:
- MFCD28502206
- MOL File:
- 1361951-15-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-28 20:33:29
| Density | 1.340±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility |
DMSO:86.0(Max Conc. mg/mL);200.74(Max Conc. mM) Ethanol:6.0(Max Conc. mg/mL);14.34(Max Conc. mM) |
| form | A crystalline solid |
| pka | 15.184±0.29(predicted) |
| color | White to light yellow |
| FDA UNII | EOB0N7BOY4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
TP-3654 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29571 | TP-3654 ≥98% | 1361951-15-6 | 5mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 29571 | TP-3654 ≥98% | 1361951-15-6 | 10mg | $118 | 2026-04-30 | Buy |
| Cayman Chemical | 29571 | TP-3654 ≥98% | 1361951-15-6 | 25mg | $242 | 2026-04-30 | Buy |
| ChemScene | CS-6293 | TP-3654 99.96% | 1361951-15-6 | 5mg | $65 | 2026-06-04 | Buy |
| ChemScene | CS-6293 | TP-3654 99.96% | 1361951-15-6 | 10mg | $103 | 2026-06-04 | Buy |
TP-3654 Chemical Properties, Uses, Production
Uses
TP-3654 is a second-generation PIM inhibitor, displaying submicromolar activity in pharmacodynamic biomarker modulation, cell proliferation studies, and colony formation assays.
in vivo
Oral dosing of 200 mg/kg TP-3654 significantly reduces both UM-UC-3 and PC-3 tumor growth measured by volume (caliper) and by final tumor weight, with no significant changes in body weight or gross adverse toxicity[1].
TP-3654 Preparation Products And Raw materials
Raw materials
Preparation Products
Global Suppliers ( 90)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 | sales@sun-shinechem.com | China | 1197 | 64 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4860 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai CR Corporation Limited | 13917420128 13062833949 | fred.wen@crcorporation.cn | China | 9769 | 58 |
1361951-15-6 (TP-3654) Related Search:
4-{6-[(oxan-4-yl)amino]imidazo[1,2-b]pyridazin-3-yl}benzaldehyde
Benzenemethanol, 3-[6-[(4-hydroxycyclohexyl)amino]imidazo[1,2-b]pyridazin-3-yl]-
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4-{6-[(3-hydroxypropyl)amino]imidazo[1,2-b]pyridazin-3-yl}phenol
N-(oxan-4-yl)-3-(pyridin-3-yl)imidazo[1,2-b]pyridazin-6-amine
1of2
TP-3654
CS-2702
TP3654 ;TP 3654
Cyclohexanemethanol, α,α-dimethyl-4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]-, trans-
TP3654,inhibit,Pim,TP 3654,Pim kinases,Inhibitor,TP-3654
2-(trans-4-((3-(3-(Trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol
TP-3654, 10 mM in DMSO
TP-3654 ，S6774
2-((1r,4r)-4-((3-(3-(Trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol
trans-α,α-Dimethyl-4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]cyclohexanemethanol
Nuvisertib
TP3654
1361951-15-6
API
