- TP-3654
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- $48.00
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2026-06-02
- CAS:1361951-15-6
- Purity: 99.80%
- Supply Ability: 10g
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| | TP-3654 Basic information |
| Product Name: | TP-3654 | | Synonyms: | TP-3654;CS-2702;TP3654 ;TP 3654;Cyclohexanemethanol, α,α-dimethyl-4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]-, trans-;TP3654,inhibit,Pim,TP 3654,Pim kinases,Inhibitor,TP-3654;2-(trans-4-((3-(3-(Trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexyl)propan-2-ol;TP-3654, 10 mM in DMSO;TP-3654 ，S6774 | | CAS: | 1361951-15-6 | | MF: | C22H25F3N4O | | MW: | 418.46 | | EINECS: | | | Product Categories: | API | | Mol File: | 1361951-15-6.mol |  |
| | TP-3654 Chemical Properties |
| density | 1.340±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:86.0(Max Conc. mg/mL);200.74(Max Conc. mM)
Ethanol:6.0(Max Conc. mg/mL);14.34(Max Conc. mM) | | form | A crystalline solid | | pka | 15.184±0.29(predicted) | | color | White to light yellow |
| | TP-3654 Usage And Synthesis |
| Uses | TP-3654 is a second-generation PIM inhibitor, displaying submicromolar activity in pharmacodynamic biomarker modulation, cell proliferation studies, and colony formation assays. | | in vivo | Oral dosing of 200 mg/kg TP-3654 significantly reduces both UM-UC-3 and PC-3 tumor growth measured by volume (caliper) and by final tumor weight, with no significant changes in body weight or gross adverse toxicity[1]. |
| | TP-3654 Preparation Products And Raw materials |
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