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AZ 12216052

AZ 12216052 Structure
AZ 12216052 structure
CAS No.
1290628-31-7
Chemical Name:
AZ 12216052
Synonyms
AZ 12216052;AZ12216052 >=98% (HPLC);2-((4-Bromobenzyl)thio)-N-(4-(sec-butyl)phenyl)acetamide;2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide;Acetamide, 2-[[(4-bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]-
CBNumber:
CB93146258
Molecular Formula:
C19H22BrNOS
Molecular Weight:
392.35308
MDL Number:
MFCD20926426
MOL File:
1290628-31-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-22 18:57:36
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AZ 12216052 Properties

Boiling point 526.9±45.0 °C(Predicted)
Density 1.323±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: soluble
form A crystalline solid
pka 13.70±0.70(Predicted)
color White to off-white

AZ 12216052 price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29460 AZ 12216052 ≥98% 1290628-31-7 1mg $42 2026-04-30 Buy
Cayman Chemical 29460 AZ 12216052 ≥98% 1290628-31-7 5mg $115 2026-04-30 Buy
Cayman Chemical 29460 AZ 12216052 ≥98% 1290628-31-7 10mg $203 2026-04-30 Buy
Cayman Chemical 29460 AZ 12216052 ≥98% 1290628-31-7 25mg $454 2026-04-30 Buy
Biosynth QBC62831 AZ 12216052 1290628-31-7 25mg $899.5 2026-06-04 Buy
Product number Packaging Price Buy
29460 1mg $42 Buy
29460 5mg $115 Buy
29460 10mg $203 Buy
29460 25mg $454 Buy
QBC62831 25mg $899.5 Buy

AZ 12216052 Chemical Properties, Uses, Production

Description

AZ 12216052 is a positive allosteric modulator of metabotropic glutamate receptor 8 (mGluR8). It potentiates glutamate-induced [35S]GTPγS binding in GHEK cells expressing human mGluR8b (EC50 = 1 μM). In a cell-based model of Parkinson’s disease, AZ 12216052 inhibits MPP+-induced decreases in the viability of undifferentiated SH-SY5Y cells when used at concentrations ranging from 0.001 to 1 μM and in retinoic acid-differentiated SH-SY5Y cells at 0.1 and 1 μM. AZ 12216052 (10 mg/kg) increases the time spent in the open areas of the elevated zero maze and reduces the acoustic startle response in mice, indicating anxiolytic-like activity in response to avoidable and unavoidable anxiogenic stimuli, respectively.

Uses

AZ 12216052 is a positive allosteric modulator of mGluR8, which are attractive therapeutic targets for anxiety disorders.

in vivo

AZ 12216052 (10 mg/kg; i.p.; 2 h prior to testing) reduces measures of anxiety, without affecting the velocity of the mice[3].
AZ12216052 (10 mg/kg; i.p.; single dose) exhibits remaining anxiolytic effects, might involve mGluR4 in mGluR8 / mice, as the mGluR4 PAM (Positive Allosteric Modulator) VU 0155041 also reduces measures of anxiety in wild-type mice[4].

Animal Model:WT and Apolipoprotein E-deficient (Apoe/) mice (C57BL/6J, 2-month-old) in the elevated zero maze[3]
Dosage:10 mg/kg
Administration:Intraperitoneal injection; singel dose, 2 h prior to testing
Result:Reduced measures of anxiety in the elevated zero maze without affecting the velocity of the mice.
Reduced the acoustic startle response.

IC 50

mGlu8

References

[1] ROBERT M. DUVOISIN . Acute pharmacological modulation of mGluR8 reduces measures of anxiety[J]. Behavioural Brain Research, 2010, 212 2: Pages 168-173. DOI: 10.1016/j.bbr.2010.04.006
[2] D. JANTAS . Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: The impact of cell differentiation state[J]. Neuropharmacology, 2014, 83: Pages 36-53. DOI: 10.1016/j.neuropharm.2014.03.019

AZ 12216052 Preparation Products And Raw materials

Raw materials

Preparation Products

AZ 12216052 Suppliers

Global Suppliers ( 29)
Supplier Tel Email Country ProdList Advantage
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9729 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Shanghai Dongyang Biotechnology Co., Ltd. 0512-13601744364 13601744364 chemsharker@126.com China 1161 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 44927 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
Supplier Advantage
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Chaolan Chemical Technology Center 58
Shanghai Hongye Biotechnology Co. Ltd 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
Shanghai Dongyang Biotechnology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
Beijing Jin Ming Biotechnology Co., Ltd. 58

View Latest Price from AZ 12216052 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AZ12216052 pictures 2026-04-22 AZ12216052
1290628-31-7
 $31.00-119.00 99.78% 10g TargetMol Chemicals Inc.
  • AZ12216052 pictures
  • AZ12216052
    1290628-31-7
  • $31.00-119.00
  • 99.78%
  • TargetMol Chemicals Inc.

AZ 12216052 Spectrum

AZ 12216052(1290628-31-7)1HNMR

1290628-31-7 (AZ 12216052) Related Search:

8-Bromo-1,5-dihydro-4,1-benzothiazepin-2(3H)-one N-[4-(sec-Butyl)phenyl]-2-[(4-chlorobenzyl)sulfanyl]acetamide 2-([4-((2-[4-(sec-Butyl)anilino]-2-oxoethyl)sulfanyl)butyl]sulfanyl)-N-[4-(sec-butyl)phenyl]acetamide AZ 12216052 VU0155041 sodium salt
AZ-GHS-22

1of2

AZ 12216052 2-[[(4-Bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]acetamide AZ12216052 >=98% (HPLC) Acetamide, 2-[[(4-bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]- 2-((4-Bromobenzyl)thio)-N-(4-(sec-butyl)phenyl)acetamide 1290628-31-7