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TYRPHOSTIN B48

TYRPHOSTIN B48 structure

CAS No.: 133550-35-3

Chemical Name:: TYRPHOSTIN B48

Synonyms: 494;AG 494;A -494;CS-2755;TYRPHOSTIN B48;-494 Tyrphostin;TYRPHOSTIN AG 494;AG-494 Tyrphostin;TyrphostinAG494>AG-494;AG 494;AG494

CBNumber:: CB9319132

Molecular Formula:: C16H12N2O3

Molecular Weight:: 280.28

MDL Number:: MFCD00209863

MOL File:: 133550-35-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

Product description	Number	Pack Size	Price
Tyrphostin AG 494 >98.0%(HPLC)(N)	A2704	20mg	$82
Tyrphostin AG 494 >98.0%(HPLC)(N)	A2704	100mg	$248
AG-494 ≥98%	10010242	5mg	$38
AG-494 ≥98%	10010242	10mg	$71
AG-494 ≥98%	10010242	25mg	$165
More product size

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TYRPHOSTIN B48 Properties

Melting point	249 °C(dec.)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMSO: soluble
form	Yellow solid.
color	Light yellow to Amber to Dark green

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS07

Signal word

Danger

Hazard statements

H301-H315-H319

Precautionary statements

P264-P270-P280-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501

Safety Statements

22-24/25

RIDADR

3439

WGK Germany

HS Code

2926.90.4801

HazardClass

6.1

PackingGroup

III

NFPA 704

	0
2		0

TYRPHOSTIN B48 price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	A2704	Tyrphostin AG 494 >98.0%(HPLC)(N)	133550-35-3	20mg	$82	2025-07-31	Buy
TCI Chemical	A2704	Tyrphostin AG 494 >98.0%(HPLC)(N)	133550-35-3	100mg	$248	2025-07-31	Buy
Cayman Chemical	10010242	AG-494 ≥98%	133550-35-3	5mg	$38	2026-04-30	Buy
Cayman Chemical	10010242	AG-494 ≥98%	133550-35-3	10mg	$71	2026-04-30	Buy
Cayman Chemical	10010242	AG-494 ≥98%	133550-35-3	25mg	$165	2026-04-30	Buy

Product number	Packaging	Price	Buy
A2704	20mg	$82	Buy
A2704	100mg	$248	Buy
10010242	5mg	$38	Buy
10010242	10mg	$71	Buy
10010242	25mg	$165	Buy

TYRPHOSTIN B48 Chemical Properties,Uses,Production

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative, compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-494 is an inhibitor of epidermal growth factor receptor kinase with an IC₅₀ value of 1 μM in HT-22 cells.

Uses

AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis[1][2][3].

Biological Activity

Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC 50 = 0.7 μ M). Selective over ErbB2, PDGFR and insulin receptor kinase (IC 50 values are 42, 6 and > 100 μ M respectively).

IC 50

EGFR: 0.7 μM (IC₅₀)

References

[1]. osherov n, levitzki a. tyrphostin ag 494 blocks cdk2 activation. febs lett, 1997, 410(2-3): 187-190.
[2]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[3]. liu x, qin j, luo q, et al. cross-talk between egf and bmp9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells. j cell mol med, 2013, 17(9): 1160-1172.
[4]. bojko a1, reichert k, adamczyk a, et al. the effect of tyrphostins ag494 and ag1478 on the autocrine growth regulation of a549 and du145 cells. folia histochem cytobiol, 2012, 50(2): 186-195.

TYRPHOSTIN B48 Preparation Products And Raw materials

Raw materials

Preparation Products

TYRPHOSTIN B48 Suppliers

Global( 135)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413	contact@trustwe.com	China	5757	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38999	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +86-15965530500	nickzhang@hangyubiotech.com	China	9930	58
Aladdin Scientific		tp@aladdinsci.com	United States	54746	58
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4766	58
Nanjing Dulai Biotechnology Co., Ltd.	025-84699383-8003;025-846993838003-8003 18013301590	njduly@126.com	China	3293	55

Supplier	Advantage
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Aladdin Scientific	58
TCI (Shanghai) Development Co., Ltd.	81
Adamas Reagent, Ltd.	59
Dalian Meilun Biotech Co., Ltd.	58
Nanjing Dulai Biotechnology Co., Ltd.	55

View Lastest Price from TYRPHOSTIN B48 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	AG-494 133550-35-3	$53.00-146.00		99.50%	10g	TargetMol Chemicals Inc.
	2019-12-25	TYRPHOSTIN B48 133550-35-3	$1.00	1g	99.99%	200kg	Career Henan Chemical Co

AG-494
133550-35-3
$53.00-146.00
99.50%
TargetMol Chemicals Inc.

TYRPHOSTIN B48
133550-35-3
$1.00
99.99%
Career Henan Chemical Co

TYRPHOSTIN B48 Spectrum

TYRPHOSTIN B48(133550-35-3)¹HNMR

133550-35-3(TYRPHOSTIN B48)Related Search:

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AURORA 9522 AURORA 9504 AURORA 8967 AURORA 9549 AURORA 9545

AURORA 9521 AURORA 9859 AURORA 1302

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(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-PHENYL-2-PROPENAMIDE ALPHA-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMAMIDE A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE AG 494 N-PHENYL-3,4-DIHYDROXYBENZYLIDENECYANOACETAMIDE TYRPHOSTIN B48 TYRPHOSTIN AG 494 N-Phenyl-3,4-dihydroxybenzylidenecyanoacetamide, Tyrphostin B48 AG 494 (Tyrphostin AG 494) (E)-2-Cyano-3-(3,4-dihydrophenyl)-N-phenyl-2-propenamide (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide -2-Cyano-3-(3,4-dihydroxyphenyl) AG-494;AG 494;AG494 CS-2755 TyrphostinAG494> 2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-phenyl-, (2E)- 494 -494 Tyrphostin AG-494 Tyrphostin DNA,ErbB-1,differentiation,Epidermal growth factor receptor,Cyclin dependent kinase,EGFR,HER1,Inhibitor,CDK,autophosphorylation,osteogenic,synthesis,Tyrphostin AG494,Tyrphostin AG 494,AG-494,activation,inhibit,Cdk2,AG494 A -494 AG-494, EGF receptor tyrosine kinase AG-494, 10 mM in DMSO 133550-35-3 Cell Biology Cell Signaling and Neuroscience BioChemical Receptor Tyrosine Kinase Inhibitors Kinase/Phosphatase Biology Epidermal Growth Factor Receptor (EGFR) API Intracellular Signaling Protein Kinase