- AG-494
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- $83.00
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2026-07-27
- CAS:133550-35-3
- Purity: 99.50%
- Supply Ability: 10g
- TYRPHOSTIN B48
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- $1.00
-
2019-12-25
- CAS:133550-35-3
- Min. Order: 1g
- Purity: 99.99%
- Supply Ability: 200kg
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| | TYRPHOSTIN B48 Basic information |
| Product Name: | TYRPHOSTIN B48 | | Synonyms: | (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-PHENYL-2-PROPENAMIDE;ALPHA-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE;A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMAMIDE;A-CYANO-(3,4-DIHYDROXY)-N-PHENYLCINNAMIDE;AG 494;N-PHENYL-3,4-DIHYDROXYBENZYLIDENECYANOACETAMIDE;TYRPHOSTIN B48;TYRPHOSTIN AG 494 | | CAS: | 133550-35-3 | | MF: | C16H12N2O3 | | MW: | 280.28 | | EINECS: | | | Product Categories: | API;Intracellular Signaling;Protein Kinase | | Mol File: | 133550-35-3.mol |  |
| | TYRPHOSTIN B48 Chemical Properties |
| Melting point | 249 °C(dec.) | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | DMSO: soluble | | form | Yellow solid. | | color | Light yellow to Amber to Dark green |
| Safety Statements | 22-24/25 | | RIDADR | 3439 | | WGK Germany | 3 | | HS Code | 2926.90.4801 | | HazardClass | 6.1 | | PackingGroup | III |
| | TYRPHOSTIN B48 Usage And Synthesis |
| Description | Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative, compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-494 is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 1 μM in HT-22 cells. | | Uses | AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis[1][2][3]. | | Biological Activity | Potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC 50 = 0.7 μ M). Selective over ErbB2, PDGFR and insulin receptor kinase (IC 50 values are 42, 6 and > 100 μ M respectively). | | IC 50 | EGFR: 0.7 μM (IC50) | | references | [1]. osherov n, levitzki a. tyrphostin ag 494 blocks cdk2 activation. febs lett, 1997, 410(2-3): 187-190.
[2]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[3]. liu x, qin j, luo q, et al. cross-talk between egf and bmp9 signalling pathways regulates the osteogenic differentiation of mesenchymal stem cells. j cell mol med, 2013, 17(9): 1160-1172.
[4]. bojko a1, reichert k, adamczyk a, et al. the effect of tyrphostins ag494 and ag1478 on the autocrine growth regulation of a549 and du145 cells. folia histochem cytobiol, 2012, 50(2): 186-195. |
| | TYRPHOSTIN B48 Preparation Products And Raw materials |
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