Spiroxamine
- CAS No.
- 118134-30-8
- Chemical Name:
- Spiroxamine
- Synonyms
- SPIROXAMIN;IMpulse;KWG 4168;Spiro aMine;Spiroxamine;Spirocycline;Spiroxamine 0;Spirocyclovir;Prosper Hoggar;SpiroketalaMine
- CBNumber:
- CB9324635
- Molecular Formula:
- C18H35NO2
- Molecular Weight:
- 297.48
- MDL Number:
- MFCD03095708
- MOL File:
- 118134-30-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | <25 °C |
|---|---|
| Boiling point | bp 120° at 0.067 hPa |
| Density | 0.96±0.1 g/cm3(Predicted) |
| refractive index | nD20 1.4662 |
| Flash point | 147 °C |
| storage temp. | 0-6°C |
| solubility | Chloroform: Slightly Soluble |
| pka | 6.9(at 25℃) |
| form | Liquid |
| color | Colorless to light yellow |
| Henry's Law Constant | 4.0×102 mol/(m3Pa) at 25℃, Maniere et al. (2011) |
| Stability | Hygroscopic |
| Major Application |
agriculture environmental |
| InChI | 1S/C18H35NO2/c1-6-12-19(7-2)13-16-14-20-18(21-16)10-8-15(9-11-18)17(3,4)5/h15-16H,6-14H2,1-5H3 |
| InChIKey | PUYXTUJWRLOUCW-UHFFFAOYSA-N |
| SMILES | CCCN(CC)CC1COC2(CCC(CC2)C(C)(C)C)O1 |
| LogP | 4.880 (est) |
| EWG's Food Scores | 1-3 |
| FDA UNII | OUT5YHB7BO |
| EPA Substance Registry System | Spiroxamine (118134-30-8) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H317-H361d-H373-H410 | |||||||||
| Precautionary statements | P273-P280-P301+P312-P302+P352+P312-P304+P340+P312-P308+P313 | |||||||||
| target organs | Eyes | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 20/21/22-38-43-50/53 | |||||||||
| Safety Statements | 36/37/39-46-60-61 | |||||||||
| RIDADR | UN3082 9/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Aquatic Acute 1 Aquatic Chronic 1 Repr. 2 Skin Irrit. 2 Skin Sens. 1 STOT RE 2 |
|||||||||
| Toxicity | LD50 in rats (mg/kg): ~595 orally; >1600 dermally; LC50 in rats (mg/m3): ~2772 by inhalation; LC50 (96 hr) in rainbow trout: 18.5 mg/l (Dutzmann) | |||||||||
| NFPA 704 |
|
Spiroxamine price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 46443 | Spiroxamine mixture of diastereomers | 118134-30-8 | 100mg | $106 | 2026-04-30 | Buy |
| Cayman Chemical | 25823 | Spiroxamine ≥95% | 118134-30-8 | 50mg | $44 | 2026-04-30 | Buy |
| Cayman Chemical | 25823 | Spiroxamine ≥95% | 118134-30-8 | 100mg | $84 | 2026-04-30 | Buy |
| Cayman Chemical | 25823 | Spiroxamine ≥95% | 118134-30-8 | 250mg | $187 | 2026-04-30 | Buy |
| Cayman Chemical | 25823 | Spiroxamine ≥95% | 118134-30-8 | 250 mg | $170 | 2024-03-01 | Buy |
Spiroxamine Chemical Properties, Uses, Production
Description
Spiroxamine is a tertiary amine fungicide and an inhibitor of Δ14 reductase/Δ8→Δ7 isomerase. It inhibits the growth of N. parvum, B. dothidea, D. seriata, and L. theobromae isolates from grape vines (EC50s = 0.97-10.28 mg/L). Spiroxamine (0.03-30 μM) reduces network formation in rat cortical cultures. It is also cytotoxic to MDA-kb2 cells (EC20 = 9.29 μM).
Uses
Spiroxamine is a spiroketalamine fungicide for use on cereal crops. Spiroxamine inhibits ergosterol synthesis. Spiroxamine is used as agricultural fungicide.
Definition
ChEBI: The spiroketal resulting from the formal condensation of 4-tert-butylcyclohexanone with 3-[ethyl(propyl)amino]propane-1,2-diol. An inhibitor of ergosterol synthesis, it is a broad spectrum agricultural fungicide used particularly against powde y mildew in the production of cereals, bananas and grapes.
Production Methods
The production of spiroxamine involves a two-step synthesis process optimized for industrial scalability and environmental safety. First, a compound (referred to as X) reacts with an alkylamine in the presence of a base to form an intermediate compound (XI). In the second step, compound XI undergoes a reaction with an alkyl bromide and a base under the influence of a phase transfer catalyst to yield spiroxamine.
Mechanism of action
Systemic with protective, curative and eradicative action. Disrupts membrane function. Inhibits sterol biosynthesis in membranes.
Metabolic pathway
Spiroxamine is metabolized rapidly in plants, soils, water, and animals via similar degradation pathways. The metabolic pathways include hydrolysis and oxidation at several places in the molecule. Side chains are also degraded to various water-soluble conjugates in animals and in plants, and at the end of complete degradation to natural constituents, carbon dioxide is formed in soils as the principal metabolite. The favorable sorption characteristics rule out any possibility of appreciable translocation in soil. In wheat, the total residue is determined in forage, grain, and harvest-ready straw. In the field studies, the residues in the grain are mostly below 0.05 mg kg-1, and only in a few cases up to 0.3 mg kg-1. In the milk of cows ingesting spiroxamine residues with the feed, no residues are found in the least favorable case. In eggs of laying hens, the residue concentrations are below the limit of quantification. There are no residue concentrations detected in the hen fat, meat, and liver.
References
[1] GUOQING SUI. Trialkylamine Derivatives Containing a Triazole Moiety as Promising Ergosterol Biosynthesis Inhibitor: Design, Synthesis, and Antifungal Activity.[J]. Chemical & pharmaceutical bulletin, 2017, 2 4: 82-89. DOI: 10.1248/cpb.c16-00732
[2] CHRISTOPHER L FRANK. From the Cover: Developmental Neurotoxicants Disrupt Activity in Cortical Networks on Microelectrode Arrays: Results of Screening 86 Compounds During Neural Network Formation.[J]. Toxicological Sciences, 2017: 121-135. DOI: 10.1093/toxsci/kfx169
[3] FRANCES ORTON. Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogens.[J]. Environmental Health Perspectives, 2011, 119 6: 794-800. DOI: 10.1289/ehp.1002895
Pesticide Type
Fungicide
Spiroxamine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Shanghai JONLN Reagent Co., Ltd. | 400-0066400 13621662912 | 422131432@qq.com | China | 9970 | 55 |
| Alta Scientific Co., Ltd. | 022-6537-8550 15522853686 | sales@altasci.com.cn | China | 4508 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shandong Xiya Chemical Co., Ltd. | 4009903999 13395398332 | sales@xiyashiji.com | China | 20788 | 60 |
| Raw material medicin reagent co.,Ltd | sales@njromanme.com | China | 4511 | 58 |
View Latest Price from Spiroxamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-17 | Spiroxamine
118134-30-8
|
$29.00 | 99.67% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-14 | SPIROXAMINE
118134-30-8
|
100kg | 95% | 15ton | Qingdao Trust Agri Chemical Co.,Ltd | ||
 |
2021-11-13 | SPIROXAMINE
118134-30-8
|
$10.00 | 1Kg/Bag | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd |
-
- Spiroxamine
118134-30-8
- $29.00
- 99.67%
- TargetMol Chemicals Inc.
-
- SPIROXAMINE
118134-30-8
- $0.00
- 95%
- Qingdao Trust Agri Chemical Co.,Ltd
-
- SPIROXAMINE
118134-30-8
- $10.00
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
