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5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid

5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid structure

CAS No.: 61727-33-1

Chemical Name:: 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid

Synonyms: BUTTPARK 97\18-95;AKOS BBS-00000276;5-CHLORO-2-(METHYLTHIO)PYRIMIDINE-4-CAR&;Chloro-2-(Methylthio)pyriMidine-4-carbox;5-Chloro-2-(methylthio)-4-pyrimidinecarboxylic Acid;5-CHLORO-2-(METHYLTHIO)PYRIMIDINE-4-CARBOXYLIC ACID;6-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid;5-Chloro-2-(methylthio)-pyrimidin-4-carboxylic acid;5-Chloro-2-(methylthio)pyrimidine-4-carboxylicAcid>4-Pyrimidinecarboxylic acid, 5-chloro-2-(methylthio)-

CBNumber:: CB9335251

Molecular Formula:: C6H5ClN2O2S

Molecular Weight:: 204.64

MDL Number:: MFCD00173907

MOL File:: 61727-33-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 04:58:19

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5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid Properties

Melting point	165 °C (dec.)
Boiling point	396.4±22.0 °C(Predicted)
Density	1.59±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	powder to crystal
pka	1.20±0.25(Predicted)
color	Light yellow to Yellow to Orange
InChI	InChI=1S/C6H5ClN2O2S/c1-12-6-8-2-3(7)4(9-6)5(10)11/h2H,1H3,(H,10,11)
InChIKey	SEPCYCDQJZTPHO-UHFFFAOYSA-N
SMILES	C1(SC)=NC=C(Cl)C(C(O)=O)=N1
CAS DataBase Reference	61727-33-1(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36-37/38-36/37/38

Safety Statements

26-36/37-37/39

WGK Germany

Hazard Note

Irritant

HS Code

2933599590

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	661244	5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid 95%	61727-33-1	1g	$80	2023-01-07	Buy
TCI Chemical	C2549	5-Chloro-2-(methylthio)pyrimidine-4-carboxylic Acid >97.0%(GC)(T)	61727-33-1	1g	$32	2026-04-30	Buy
TCI Chemical	C2549	5-Chloro-2-(methylthio)pyrimidine-4-carboxylic Acid >97.0%(GC)(T)	61727-33-1	5g	$91	2026-04-30	Buy
AstaTech	64332	5-CHLORO-2-(METHYLTHIO)PYRIMIDINE-4-CARBOXYLIC ACID 97%	61727-33-1	1G	$19	2026-04-30	Buy
AstaTech	64332	5-CHLORO-2-(METHYLTHIO)PYRIMIDINE-4-CARBOXYLIC ACID 97%	61727-33-1	5G	$28	2026-04-30	Buy

Product number	Packaging	Price	Buy
661244	1g	$80	Buy
C2549	1g	$32	Buy
C2549	5g	$91	Buy
64332	1G	$19	Buy
64332	5G	$28	Buy

5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid Chemical Properties, Uses, Production

Uses

5-Chloro-2-(methylthio)-4-pyrimidinecarboxylic acid is a synthetic intermediate in the preparation of GSK3β inhibitors and non-nucleoside reverse transcriptase inhibitors for treating HIV infection.

Synthesis

Dissolve S-methylthiourea sulfate (30.0 g) in a warm solution of viscochloric acid (18.3 g) in water (430 mL) and cool to 18C. . Triethylamine (33.0 g) was added over 1.5 hours with mechanical stirring. The next day a little concentrated hydrochloric acid was added to the solution and the resulting tar was removed by filtration. The solution was further acidified to pH = 4 to give the solid product (8.5 g, 38%), 5-chloro-2-(methylthio)pyrimidine-4-carboxylic acid in yield (8.5 g, 38%). Melting point: 167-169C.

5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Triethylamine 2-Methyl-2-thiopseudourea sulfate Hydrochloric acid Mucochloric acid

Preparation Products

5-Chloro-alpha,alpha-diphenyl-2-methylthio-4-pyrimidinemethanol

5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid Suppliers

Global Suppliers ( 200)

Supplier	Tel	Email	Country	ProdList	Advantage
THchemica Co.,Ltd.	0573-82835115 18969301519	tly1019@126.com	China	276	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64

Supplier	Advantage
THchemica Co.,Ltd.	58
J & K SCIENTIFIC LTD.	76
TCI (Shanghai) Development Co., Ltd.	81
ShangHai DEMO Chemical Co.,Ltd	57
Energy Chemical	61
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Jia Xing Isenchem Co.,Ltd	66
Pure Chemistry Scientific Inc.	62
Accela ChemBio Co.,Ltd.	64

View Latest Price from 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-08-20	5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid 61727-33-1	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
	2019-07-11	5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid 61727-33-1	$1.00	1KG	99%	25kg	Career Henan Chemical Co

5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid
61727-33-1
$1.10
99.00%
Dideu Industries Group Limited

5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid
61727-33-1
$1.00
99%
Career Henan Chemical Co

5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid Spectrum

5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid(61727-33-1)¹HNMR

61727-33-1 (5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid) Related Search:

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Carboxylic acid 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid 2-[(2-amino-2-oxoethyl)thio]-5-chloropyrimidine-4-carboxylic acid 5-chloro-2-[(3-cyanopropyl)thio]pyrimidine-4-carboxylic acid 2-(benzylthio)-5-chloropyrimidine-4-carboxylic acid

AKOS BBS-00001997 AKOS BBS-00000062 AKOS BBS-00001669

1of4

AKOS BBS-00000276 5-CHLORO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLIC ACID 5-CHLORO-2-(METHYLTHIO)PYRIMIDINE-4-CARBOXYLIC ACID 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid 98% 5-Chloro-2-methylsulfanyl-pyrimidine-4-carboxylic acid BUTTPARK 97\18-95 5-CHLORO-2-(METHYLTHIO)PYRIMIDINE-4-CAR& 5-Chloro-2-(methylsulphanyl)pyrimidine-4-carboxylic acid, 4-Carboxy-5-chloropyrimidin-2-yl methyl sulphide, 4-Carboxy-5-chloro-2-(methylthio)pyrimidine 5-Chloro-2-(methylsulphanyl)pyrimidine-4-carboxylic acid 98% 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid, 4-Carboxy-5-chloropyrimidin-2-yl methyl sulphide, 4-Carboxy-5-chloro-2-(methylthio)-1,3-diazine 5-Chloro-2-(methylthio)-4-pyrimidinecarboxylic Acid Chloro-2-(Methylthio)pyriMidine-4-carbox 6-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid 5-Chloro-2-(methylthio)pyrimidine-4-carboxylicAcid> 4-Pyrimidinecarboxylic acid, 5-chloro-2-(methylthio)- 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid ISO 9001：2015 REACH 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid，97% min 5-Chloro-2-(methylsulphanyl)pyrimidine-4-carboxylic acid 5-Chloro-2-(methylthio)-pyrimidin-4-carboxylic acid 61727-33-1 C6H5ClN2O2S Pyrimidines Halogenated Heterocycles Heterocyclic Building Blocks Building Blocks Heterocycle-Pyrimidine series pharmacetical Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyrimidines PyrimidinesHeterocyclic Building Blocks