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Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate structure

CAS No.: 5909-24-0

Chemical Name:: Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate

Synonyms: 4-Chloro-5-ethoxycarbonyl-2-methylthiopyrimidine;2-METHYLTHIO-4-CHLORO-5-ETHOXYCARBONYLPYRIMIDINE;ethyl 4-chloro-2-methylthio-5-pyrimidine-carboxyl;4-Chloro-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester;NSC 123534;SIEHE AV22429;BUTTPARK 45\03-53;Avanafil Impurity 69;Ethyl4-chloro-2-met...;thio-5-pyrimidinecarboxyL

CBNumber:: CB2141204

Molecular Formula:: C8H9ClN2O2S

Molecular Weight:: 232.69

MDL Number:: MFCD00006085

MOL File:: 5909-24-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:55:55

Product description	Number	Pack Size	Price
Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate 98%	145963	25g	$99.3
Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate 98%	145963	5g	$23.5
Ethyl 4-Chloro-2-(methylthio)pyrimidine-5-carboxylate >97.0%(GC)	E0841	5g	$23
Ethyl 4-Chloro-2-(methylthio)pyrimidine-5-carboxylate >97.0%(GC)	E0841	25g	$70
Ethyl 4-Chloro-2-methylthiopyrimidine-5-carboxylate	E8604-73	5g	$326
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Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Properties

Melting point	60-63 °C (lit.)
Boiling point	132°C/0.4mmHg(lit.)
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform, Ethyl Acetate
pka	-2.19±0.29(Predicted)
form	Crystalline Powder
color	White to light yellow to beige
InChI	InChI=1S/C8H9ClN2O2S/c1-3-13-7(12)5-4-10-8(14-2)11-6(5)9/h4H,3H2,1-2H3
InChIKey	SNNHLSHDDGJVDM-UHFFFAOYSA-N
SMILES	C1(SC)=NC=C(C(OCC)=O)C(Cl)=N1
CAS DataBase Reference	5909-24-0(CAS DataBase Reference)
FDA UNII	3EZY6B6CLY
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

Hazard Note

Irritant

HazardClass

IRRITANT, KEEP COLD

HS Code

29339900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

REACH Registrations

Active

NFPA 704

	1
2		0

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate price More Price(88)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	145963	Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate 98%	5909-24-0	25g	$99.3	2026-04-30	Buy
Sigma-Aldrich	145963	Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate 98%	5909-24-0	5g	$23.5	2025-07-31	Buy
TCI Chemical	E0841	Ethyl 4-Chloro-2-(methylthio)pyrimidine-5-carboxylate >97.0%(GC)	5909-24-0	5g	$23	2026-04-30	Buy
TCI Chemical	E0841	Ethyl 4-Chloro-2-(methylthio)pyrimidine-5-carboxylate >97.0%(GC)	5909-24-0	25g	$70	2026-04-30	Buy
Usbiological	E8604-73	Ethyl 4-Chloro-2-methylthiopyrimidine-5-carboxylate		5g	$326	2026-06-03	Buy

Product number	Packaging	Price	Buy
145963	25g	$99.3	Buy
145963	5g	$23.5	Buy
E0841	5g	$23	Buy
E0841	25g	$70	Buy
E8604-73	5g	$326	Buy

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Chemical Properties,Uses,Production

Chemical Properties

off white to light yellow solid

Uses

A pyrimidine derivative as inhibitor of Streptococcus faecium, Lactobacillus casei, and Pediococcus cerevisiae

Uses

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate was used in the synthesis of pyrimidinopyridones, potential inhibitors of the FMS tyrosine kinase.

Synthesis

1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTER

53554-29-3

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate

5909-24-0

General procedure for the synthesis of ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate from ethyl 4-hydroxy-2-methylthiopyrimidine-5-carboxylate: ethyl 4-hydroxy-2-methylthiopyrimidine-5-carboxylate (30 g, 140 mmol) was placed in a three-necked flask. Thionyl chloride (20 g, 168 mmol) was added slowly. The reaction system was heated to 60 °C and maintained at this temperature for 3 hours. After completion of the reaction, the reaction solution was cooled to 0-5 °C. 100 ml of ice water was slowly added and crystallization was stirred at 0-5°C for 1-2 hours. The solid product was collected by filtration and dried under vacuum at 50 °C to give 30.1 g of white solid product. The yield was 92% and the purity was 99.8% by HPLC.

References

[1] Patent: CN108101853, 2018, A. Location in patent: Paragraph 0015-0018
[2] Patent: WO2006/71940, 2006, A2. Location in patent: Page/Page column 354
[3] Patent: CN108707141, 2018, A. Location in patent: Paragraph 0027; 0030; 0039; 0048
[4] Patent: US2009/54395, 2009, A1. Location in patent: Page/Page column 45-46
[5] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 15, p. 1645 - 1648

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Preparation Products And Raw materials

Raw materials

Ethanol Acetic anhydride Potassium hydroxide Diethyl ethoxymethylenemalonate Triethyl orthoformate

Sodium Phosphorus oxitrichloride Benzene 2-Methyl-2-thiopseudourea sulfate Diethyl malonate

Thionyl chloride

1of3

Preparation Products

4-(ethylaMino)-2-(Methylthio)pyriMidine-5-carbaldehyde (4-CHLORO-2-METHYLSULFANYL-PYRIMIDIN-5-YL)-METHANOL 5-PyriMidinecarboxylic acid, 4-[[(3-chloro-4-Methoxyphenyl)Methyl]aMino]-2-[(2S)-2-(hydroxyMethyl)- 1-pyrrolidinyl]- 4-Chloro-2-(methylthio)pyrimidine-5-carboxaldehyde 4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Suppliers

Global( 506)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Changshu New Venture Imp.&Exp. Co.,Ltd.	0512-52678575 13776233393	nvchem_deng@163.com	China	256	58
Allfluoro pharmaceutical co. ltd.	+86-400-0216110 +86-15958047586	sales@allfluoro.com	China	11385	58
Hubei Deli Pharmaceutical Technology Co., Ltd.	+86-13372285931 19237964946	dl@delipharm.com	China	97	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Handan City Zechi trading Co., LTD	+8619003396151	13165586887@163.com	China	475	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55

Supplier	Advantage
Changshu New Venture Imp.&Exp. Co.,Ltd.	58
Allfluoro pharmaceutical co. ltd.	58
Hubei Deli Pharmaceutical Technology Co., Ltd.	58
Henan Bao Enluo International TradeCo.，LTD	58
Anhui Ruihan Technology Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Handan City Zechi trading Co., LTD	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55

View Lastest Price from Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-08	Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate 5909-24-0		1KG	98%min	500 KG	WUHAN FORTUNA CHEMICAL CO., LTD
2026-02-25	Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate 5909-24-0	$60.00-100.00	100kg	99.99%	100Tons	Hebei Dangtong Import and export Co LTD
2025-09-28	Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate 5909-24-0	$1.00	100g	99	1000	Handan City Zechi trading Co., LTD

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate
5909-24-0
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate
5909-24-0
$60.00-100.00
99.99%
Hebei Dangtong Import and export Co LTD

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate
5909-24-0
$1.00
99
Handan City Zechi trading Co., LTD

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate Spectrum

Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate(5909-24-0)MS Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate(5909-24-0)¹HNMR Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate(5909-24-0)IR1 Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate(5909-24-0)IR2 Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate(5909-24-0)Raman

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5-Pyrimidinecarboxylic acid Pyrimidine-5-carboxaldehyde 2-(Methylthio)-5-pyrimidinecarboxylic acid ethyl ester

1of4

BUTTPARK 45\03-53 ETHYL 4-CHLORO-2-METHYLTHIO-5-PYRIMIDINECARBOXYLATE ETHYL 4-CHLORO-2-METHYLTHIOPYRIMIDINE-5-CARBOXYLATE ETHYL 4-CHLORO-2-(METHYLSULFANYL)-5-PYRIMIDINECARBOXYLATE 4-Chloro-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester ethyl 4-chloro-2-methylthio-5-pyrimidine-carboxyl SIEHE AV22429 ETHYL 4-CHLORO-2-METHYLTHIO-5-PYRIMIDIN& 4-chloro-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate 98% ethyl 2-Methylsulfanyl-4-chloropyrimidine-4-carboxylate Ethyl 4-chloro-2-methylthiopyrimidine- 4-Chloro-5-(ethoxycarbonyl)-2-(methylthio)pyrimidine, 4-Chloro-5-(ethoxycarbonyl)-2-(methylsulphanyl)-1,3-diazine Ethyl4-chloro-2-(methylthio)pyrimidine-5-carboxylate,98% thyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate 4-Chloro-2-methylsulfanyl- ethyle4-chloro-2-methylthio-5-pyrimidinecarboxylate 4-CHLORO-2-METHYLTHIO-5-PYRIMIDINE-CARBOXYLATE 4-Chloro-(2-methylthio)-5-pyrimidinecarboxylic acid ethyl ester 2-Methylsulfanyl-4-chloropyrimidine-4-carboxylic acid ethyl ester Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate ,97% Ethyl 4-chloro-2-Methylthio-5-pyriMidinecarboxylat Ethyl 4-chloro-2-(Methyls... 4-Chloro-2-methane-sulfanylpyrimidine-5-carboxylic Acid Ethyl Ester NSC 123534 5-Pyrimidinecarboxylic acid, 4-chloro-2-(methylthio)-, ethyl ester 2-(Methylthio)-4-chloropyrimidine-5-carboxylic acid ethyl ester Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate,98% JR-8417, Ethyl 4-chloro-2-methylthio-5-pyrimidine carboxylate, 97% Ethyl4-chloro-2-met... Ethyl4-Chloro-2-(methylthio)pyrimidine-5-carboxylate> thio-5-pyrimidinecarboxyL Avanafil Impurity 69 Ethyl 4-chloro-2-methylthio-5-pyrimidinecarboxylate ISO 9001：2015 REACH Avanafil intermediates，ethyl 4-chloro-2-methylthio-5- pyrimidine-carboxyl RSSYY(Lurasidone Hydrochloride)-7 Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate (Avanafil Impurity) 4-Chloro-2-methylthiopyrimidin-5-carboxylic acid ethyl ester 2-METHYLTHIO-4-CHLORO-5-ETHOXYCARBONYLPYRIMIDINE 4-Chloro-5-ethoxycarbonyl-2-methylthiopyrimidine 5909-24-0 5924-24-0 5929-24-0 C8H9ClN2O2S Building Blocks Heterocyclic Building Blocks Halogenated Heterocycles Pyrimidines Pyrimidines Nucleotides and Nucleosides APIs & Intermediate Pyrimidine Heterocycle-Pyrimidine series Bases & Related Reagents Heterocycles Nucleotides Sulfur & Selenium Compounds Building Blocks