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5-Amino-4,6-dichloro-2-methylpyrimidine

5-Amino-4,6-dichloro-2-methylpyrimidine Structure
5-Amino-4,6-dichloro-2-methylpyrimidine structure
CAS No.
39906-04-2
Chemical Name:
5-Amino-4,6-dichloro-2-methylpyrimidine
Synonyms
4,6-DICHLORO-2-METHYLPYRIMIDIN-5-AMINE;TIMTEC-BB SBB003764;2-Methyl-4,6-dichloro-5-aminop;Methyl-4,6-dichloro-5-aminopyrimidine;4,6-dichloro-2-methyl-5-pyrimidinamine;5-AMINO-4,6-DICHLORO-2-METHYLPYRIMIDINE;2-METHYL-4,6-DICHLORO-5-AMINOPYRIMIDINE;5-Amino-4,6-Dichloro-2-Methylpytimidine;4,6-dichloro-2-Methyl-5-aMino-pyriMidine;5-Pyrimidinamine, 4,6-dichloro-2-methyl-
CBNumber:
CB9368291
Molecular Formula:
C5H5Cl2N3
Molecular Weight:
178.02
MDL Number:
MFCD00194053
MOL File:
39906-04-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:54:27
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5-Amino-4,6-dichloro-2-methylpyrimidine Properties

Melting point 70-73 °C (lit.)
Boiling point 257.7±35.0 °C(Predicted)
Density 1.504±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Methanol
pka -2.55±0.39(Predicted)
form powder to crystal
color White to Yellow to Green
InChI InChI=1S/C5H5Cl2N3/c1-2-9-4(6)3(8)5(7)10-2/h8H2,1H3
InChIKey FKRXXAMAHOGYNT-UHFFFAOYSA-N
SMILES C1(C)=NC(Cl)=C(N)C(Cl)=N1
CAS DataBase Reference 39906-04-2(CAS DataBase Reference)
UNSPSC Code 12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
Hazard Note  Irritant
HS Code  29335990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
REACH Registrations Inactive
NFPA 704
0
2 0

5-Amino-4,6-dichloro-2-methylpyrimidine price More Price(61)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 548235 5-Amino-4,6-dichloro-2-methylpyrimidine 97% 39906-04-2 10g $119 2023-06-20 Buy
TCI Chemical A1946 5-Amino-4,6-dichloro-2-methylpyrimidine >98.0%(GC) 39906-04-2 5g $121 2026-04-30 Buy
TCI Chemical A1946 5-Amino-4,6-dichloro-2-methylpyrimidine >98.0%(GC) 39906-04-2 25g $481 2026-04-30 Buy
Usbiological 258470 5-Amino-4,6-dichloro-2-methylpyrimidine Asreported 39906-04-2 50g $595 2026-06-03 Buy
Usbiological 258470 5-Amino-4,6-dichloro-2-methylpyrimidine Asreported 39906-04-2 100g $839 2026-06-03 Buy
Product number Packaging Price Buy
548235 10g $119 Buy
A1946 5g $121 Buy
A1946 25g $481 Buy
258470 50g $595 Buy
258470 100g $839 Buy

5-Amino-4,6-dichloro-2-methylpyrimidine Chemical Properties, Uses, Production

Appearance

White to Yellow to Green powder to crystal

Uses

5-Amino-4,6-dichloro-2-methylpyrimidine is a useful research chemical for organic synthesis and other chemical and pharmacological processes.

Application

5-Amino-4,6-dichloro-2-methylpyrimidine can be used as an intermediate in medical synthesis, such as the preparation of mosonidine. Mosonidine is a widely used antihypertensive drug.

Synthesis

4,6-Dichloro-2-methyl-5-nitropyrimidine

13162-43-1

5-Amino-4,6-dichloro-2-methylpyrimidine

39906-04-2

GENERAL METHOD: 10% Pd/C catalyst (0.05 g) was added to a solution of 4,6-dichloro-2-methyl-5-nitropyrimidine (4.48 mmol) in ethyl acetate (EA, 20 mL) in a Parr hydrogenation reactor. Subsequently, the air in the reactor was replaced with nitrogen three times and the hydrogenation reaction was carried out at room temperature and at atmospheric pressure. Upon completion of the reaction, the Pd/C catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated to afford the intermediate 2-methyl-4,6-dichloro-5-aminopyrimidine (11a). The product was a light-colored solid, yield: 84.0%; mass spectrum (ESI) m/z: 177.94 [M + H]+.

References

[1] European Journal of Medicinal Chemistry, 2017, vol. 140, p. 212 - 228
[2] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983, p. 1113 - 1115
[3] Khimiya Geterotsiklicheskikh Soedinenii, 1983, vol. 19, # 10, p. 1398 - 1400
[4] Journal of the Chemical Society, 1954, p. 3832,3833
[5] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 17, p. 5721 - 5726

5-Amino-4,6-dichloro-2-methylpyrimidine synthesis

13162-43-1
39906-04-2
Synthesis of 5-Amino-4,6-dichloro-2-methylpyrimidine from 4,6-Dichloro-2-methyl-5-nitropyrimidine

5-Amino-4,6-dichloro-2-methylpyrimidine Preparation Products And Raw materials

Raw materials

4,6-Dihydroxy-2-methylpyrimidine Sodium chloride Toluene Trifluoroacetic acid Phosphorus oxitrichloride
Diethylamine Diisopropylamine Diethyl ether Ethyl acetate Nitric acid
Acetic acid Methanol Sodium hydroxide Iron Magnesium sulfate
Malonic acid N-(4,6-dihydroxy-2-methylpyrimidin-5-yl)acetamide 2-Methyl-5-nitro-pyrimidine-4,6-diol

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Preparation Products

5-Amino-4,6-dichloro-2-methylpyrimidine Suppliers

Global Suppliers ( 287)
Supplier Tel Email Country ProdList Advantage
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd. 027-65388397 18164111589 3321478047@qq.com China 2002 55
Liyang Kunlu biological technology co.,ltd 0519-87310015 13813530041 200601296@qq.com China 323 58
Nanbu County Chengxin Technology Co., Ltd. 0838-5675166 15883665058 nbcxkj@126.com China 956 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd. 55
Liyang Kunlu biological technology co.,ltd 58
Nanbu County Chengxin Technology Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Energy Chemical 61
Capot Chemical Co., Ltd 66

View Latest Price from 5-Amino-4,6-dichloro-2-methylpyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-Amino-4,6-dichloro-2-methylpyrimidine pictures 2026-09-18 5-Amino-4,6-dichloro-2-methylpyrimidine
39906-04-2
 1KG 98%min 500kgs WUHAN FORTUNA CHEMICAL CO., LTD
5-Amino-4,6-dichloro-2-methylpyrimidine pictures 2026-09-02 5-Amino-4,6-dichloro-2-methylpyrimidine
39906-04-2
 $5.00 1KG 99% Henan Fengda Chemical Co., Ltd
5-Amino-4,6-dichloro-2-methylpyrimidine pictures 2025-04-04 5-Amino-4,6-dichloro-2-methylpyrimidine
39906-04-2
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

5-Amino-4,6-dichloro-2-methylpyrimidine Spectrum

5-Amino-4,6-dichloro-2-methylpyrimidine(39906-04-2)MS5-Amino-4,6-dichloro-2-methylpyrimidine(39906-04-2)1HNMR5-Amino-4,6-dichloro-2-methylpyrimidine(39906-04-2)13CNMR5-Amino-4,6-dichloro-2-methylpyrimidine(39906-04-2)IR15-Amino-4,6-dichloro-2-methylpyrimidine(39906-04-2)IR2

39906-04-2 (5-Amino-4,6-dichloro-2-methylpyrimidine) Related Search:

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Sulfamerazine Methyl acetate N,N-Dimethyl-1,4-phenylenediamine Basic Violet 1 4,6-Dichloropyrimidine
Pirimiphos-methyl Methanol Betaine Methylparaben Tris(hydroxymethyl)aminomethane
Acetonitrile Glycine Aminoethoxyvinyl glycine hydrochloride

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2-METHYL-4,6-DICHLORO-5-AMINOPYRIMIDINE TIMTEC-BB SBB003764 5-AMINO-4,6-DICHLORO-2-METHYLPYRIMIDINE 4,6-DICHLORO-2-METHYL-PYRIMIDIN-5-YLAMINE 2-Methyl-4,6-dichloro-5-aminop 2-methyl-4,6-dichloro-5-aminopyrimidine (intermediate of moxonidine hcl) 5-Amino-4,6-Dichloro-2-Methylpytimidine 4,6-Dichloro-2-methylpyrimidin-5-amine, 5-Amino-4,6-dichloro-2-methyl-1,3-diazine 4,6-dichloro-2-Methyl-5-aMino-pyriMidine 5-Amino-4,6-dichloro-2-methylpyrimidine 97% Methyl-4,6-dichloro-5-aminopyrimidine 4,6-dichloro-2-methyl-5-pyrimidinamine 5-Amino-4,6-dichloro-2-methylpyrimidine > 5-Pyrimidinamine, 4,6-dichloro-2-methyl- 2-METHYL-4,6-DICHLORO-5-AMINOPYRIMIDINE 39906-04-2 5-Amino-4,6-dichloro-2-methylpyrimidine USP/EP/BP 4,6-DICHLORO-2-METHYLPYRIMIDIN-5-AMINE 39906-04-2 C5H5N3Cl2 Heterocyclic Building Blocks Halogenated Heterocycles Pyrimidines Building Blocks Pyridines, Pyrimidines, Purines and Pteredines Pyrimidine (intermediate of moxonidine hcl) (intermediate of moxonidine) 39906-04-2 OLED