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4-Bromo-2-methyl-1-nitrobenzene

4-Bromo-2-methyl-1-nitrobenzene Structure
4-Bromo-2-methyl-1-nitrobenzene structure
CAS No.
52414-98-9
Chemical Name:
4-Bromo-2-methyl-1-nitrobenzene
Synonyms
3-Bromo-6-nitrotoluene;5-Bromo-2-nitrotoluene 98%;4-Bromo-6-methylnitrobenzene;4-BroMo-2-Methylnitrobenzene;2-Methyl-4-bromonitrobenzene;4-Bromo-2-methyl-1-nitrobenzene;5-Bromo-1-methyl-2-nitrobenzene;Benzene,4-broMo-2-Methyl-1-nitro-;2-(3-bromo-2-nitrophenyl)acetonitrile;4-Bromo-2-methyl-1-nitrobenzene, 4-Bromo-2-methylnitrobenzene
CBNumber:
CB9370708
Molecular Formula:
C7H6BrNO2
Molecular Weight:
216.03
MDL Number:
MFCD00137824
MOL File:
52414-98-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:56:27
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4-Bromo-2-methyl-1-nitrobenzene Properties

Melting point 53-55℃
Boiling point 265℃
Density 1.615
refractive index 1.6120 (estimate)
Flash point 114℃
storage temp. Sealed in dry,Room Temperature
Appearance White to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P280
HS Code  2929900090

4-Bromo-2-methyl-1-nitrobenzene price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR60239 5-Bromo-2-nitrotoluene 98% 52414-98-9 1g $21 2026-06-04 Buy
Activate Scientific AS25238 5-Bromo-2-nitrotoluene 98% 52414-98-9 5g $23 2026-06-04 Buy
Apolloscientific OR60239 5-Bromo-2-nitrotoluene 98% 52414-98-9 5g $24 2026-06-04 Buy
Activate Scientific AS25238 5-Bromo-2-nitrotoluene 98% 52414-98-9 25g $77 2026-06-04 Buy
Apolloscientific OR60239 5-Bromo-2-nitrotoluene 98% 52414-98-9 25g $39 2026-06-04 Buy
Product number Packaging Price Buy
OR60239 1g $21 Buy
AS25238 5g $23 Buy
OR60239 5g $24 Buy
AS25238 25g $77 Buy
OR60239 25g $39 Buy

4-Bromo-2-methyl-1-nitrobenzene Chemical Properties, Uses, Production

Uses

5-Bromo-2-nitrotoluene is used the synthesis of biphenylamide derivatives as Hsp90 C-terminal inhibitor for the treatment of cancer and neurodegenerative diseases.

Synthesis

4-BROMO-2-METHYLANILINE

583-75-5

4-BROMO-2-METHYL-1-NITROBENZENE

52414-98-9

General procedure for the synthesis of 4-bromo-2-methyl-1-nitrobenzene from 2-methyl-4-bromoaniline: Step 1: Synthesis of 4-bromo-2-methyl-1-nitrobenzene (193) H2O2 (3.95 mL, 64±5 mmol) was dissolved in DCM (320 mL) at 0°C, cooled and TFAA (10.93 mL, 77 mmol) was added and the mixture was stirred for 5 min at this temperature. The ice bath was then removed, a reflux condenser was installed, and a solution of 4-bromo-2-methylaniline (3 g, 16.12 mmol) in DCM (6.4 mL) was added slowly and dropwise over about 30 minutes. The reaction mixture was heated to reflux for 1 h. After cooling, the reaction mixture was washed sequentially with 30 mL of water and 30 mL of saturated NaHCO3 solution, and the organic layer was dried with MgSO4 and concentrated in vacuum. The crude product was purified by flash column chromatography to give 193 (2.57 g, 11.9 mmol, 74% yield). 1H NMR (CDCl3) δ (ppm): 7.88 (d, J = 8.6 Hz, 1H), 7.53 (d, J = 2.2 Hz, 1H), 7.49 (dd, J = 8.6, 2.2 Hz, 1H), 2.60 (s, 3H).

References

[1] Patent: WO2008/104077, 2008, A1. Location in patent: Page/Page column 122
[2] Journal of Organic Chemistry, 1955, vol. 20, p. 1458
[3] Patent: US4287201, 1981, A

4-Bromo-2-methyl-1-nitrobenzene Preparation Products And Raw materials

Raw materials

3-Methyl-4-nitroaniline 4-Bromo-2-methylaniline Trifluoroacetic anhydride Hydrogen peroxide Dichloromethane

Preparation Products

4-bromo-2-(bromomethyl)-1-nitrobenzene

4-Bromo-2-methyl-1-nitrobenzene Suppliers

Global Suppliers ( 130)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Shanghai Sphchem Co., Ltd. 021-56491756 13512199871 2819742715@qq.com China 3994 55
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Energy Chemical 61
Jia Xing Isenchem Co.,Ltd 66
Accela ChemBio Co.,Ltd. 64
Shanghai Longsheng chemical Co.,Ltd. 59
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky（shanghai）International Co.,Ltd. 50
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Shanghai Sphchem Co., Ltd. 55

View Latest Price from 4-Bromo-2-methyl-1-nitrobenzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-BROMO-2-METHYL-1-NITROBENZENE pictures 2026-09-02 4-BROMO-2-METHYL-1-NITROBENZENE
52414-98-9
 $1.00-80.00 1KG 99% Henan Fengda Chemical Co., Ltd
4-BROMO-2-METHYL-1-NITROBENZENE pictures 2020-01-09 4-BROMO-2-METHYL-1-NITROBENZENE
52414-98-9
 $9.80 1g ≥99% 100kg Career Henan Chemical Co

4-Bromo-2-methyl-1-nitrobenzene Spectrum

4-BROMO-2-METHYL-1-NITROBENZENE(52414-98-9)1HNMR4-BROMO-2-METHYL-1-NITROBENZENE(52414-98-9)FT-IR

52414-98-9 (4-Bromo-2-methyl-1-nitrobenzene) Related Search:

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1of4

3-Bromo-6-nitrotoluene 4-Bromo-6-methylnitrobenzene 5-Bromo-1-methyl-2-nitrobenzene 4-Bromo-2-methyl-1-nitrobenzene, 4-Bromo-2-methylnitrobenzene 4-BroMo-2-Methylnitrobenzene Benzene,4-broMo-2-Methyl-1-nitro- 5-Bromo-2-nitrotoluene 98% 2-Methyl-4-bromonitrobenzene 2-(3-bromo-2-nitrophenyl)acetonitrile 4-Bromo-2-methyl-1-nitrobenzene 52414-98-9