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1,3-Dioxane

1,3-Dioxane Structure
1,3-Dioxane structure
CAS No.
505-22-6
Chemical Name:
1,3-Dioxane
Synonyms
1,3-Dioxacyclohexane;M-DIOXANE;1,3-Dioxane;meta-dioxane;1,3-Dioxane>1,3-DIOXANE(M-);dihydro-m-dioxi;1,3-Dioxane,97%;1,3-Dioxane 97%;m-Dioxin, dihydro-
CBNumber:
CB9379059
Molecular Formula:
C4H8O2
Molecular Weight:
88.11
MDL Number:
MFCD00006566
MOL File:
505-22-6.mol
MSDS File:
SDS
Last updated:2026-09-12 18:56:27
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1,3-Dioxane Properties

Melting point -45 °C (lit.)
Boiling point 105-106 °C (lit.)
Density 1.032 g/mL at 25 °C (lit.)
refractive index n20/D 1.418(lit.)
Flash point 59 °F
storage temp. Flammables area
form clear liquid
color Colorless to Almost colorless
Water Solubility Fully miscible in water.
Specific Heat Capacity Cp(liquid): 1.63 J/(g·K), at 25℃
BRN 102532
Henry's Law Constant 1.8×100 mol/(m3Pa) at 25℃, O'Farrell and Waghorne (2010)
Stability Stable. Flammable. Incompatible with oxidizing agents. May form explosive peroxides in contact with the air - store under inert gas.
InChI InChI=1S/C4H8O2/c1-2-5-4-6-3-1/h1-4H2
InChIKey VDFVNEFVBPFDSB-UHFFFAOYSA-N
SMILES O1CCCOC1
EWG's Food Scores 1
FDA UNII B2C8M17I09
EPA Substance Registry System 1,3-Dioxane (505-22-6)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H302+H312+H332
Precautionary statements  P210-P280-P301+P312+P330-P302+P352+P312-P304+P340+P312
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  F,Xn
Risk Statements  11-20/21/22
Safety Statements  16
RIDADR  UN 1165 3/PG 2
WGK Germany  3
RTECS  JG8224000
HS Code  2932.99.9090
HazardClass  3.1
PackingGroup  II
Storage Class 3 - Flammable liquids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Flam. Liq. 2
Hazardous Substances Data 505-22-6(Hazardous Substances Data)
NFPA 704
3
2 0

1,3-Dioxane price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 283061 1,3-Dioxane 97% 505-22-6 5g $146 2026-04-30 Buy
TCI Chemical D0859 1,3-Dioxane >98.0%(GC) 505-22-6 25mL $96 2026-04-30 Buy
TCI Chemical D0859 1,3-Dioxane >98.0%(GC) 505-22-6 100mL $288 2026-04-30 Buy
aablocks AA003DI0 1,3-Dioxane 98% 505-22-6 1g $24 2026-05-28 Buy
aablocks AA003DI0 1,3-Dioxane 98% 505-22-6 5g $46 2026-05-28 Buy
Product number Packaging Price Buy
283061 5g $146 Buy
D0859 25mL $96 Buy
D0859 100mL $288 Buy
AA003DI0 1g $24 Buy
AA003DI0 5g $46 Buy

1,3-Dioxane Chemical Properties, Uses, Production

Chemical Properties

colourless liquid

Uses

1,3-Dioxane has been employed as solvent in the synthesis of 8- and 9-membered dioxazocines and dioxazonines.

Definition

ChEBI: 1,3-dioxane is a dioxane and a cyclic acetal.

Preparation

1,3-dioxane is prepared by the reaction of formaldehyde and 1,3-propanediol in the presence of Brnsted or Lewis acid catalysts.

General Description

Clear colorless liquid.

Air & Water Reactions

Highly flammable. Can form dangerous peroxides when exposed to air. Water soluble.

Reactivity Profile

1,3-DIOXANE is sensitive to heat. 1,3-DIOXANE can react with oxidizers.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 1,3-DIOXANE emits acrid smoke and fumes.

Fire Hazard

1,3-DIOXANE is flammable.

Purification Methods

Dry the dioxane with sodium and fractionally distil it. [Beilstein 19/1 V 11.]

1,3-Dioxane synthesis

112-31-2
504-63-2
505-22-6
Synthesis of 1,3-Dioxane from Decyl aldehyde and 1,3-Propanediol

1,3-Dioxane Preparation Products And Raw materials

Raw materials

1,3-Propanediol, 1-formate 1,3-Propanediol, 1,3-diformate 5,5-Dimethyl-1,3-dioxane Trimethylene acetate 2-Pentanone
Formic acid Carbon dioxide 1,3-Propanediol

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Preparation Products

2-Amino-1,3-propanediol Pinacolone

1,3-Dioxane Suppliers

Global Suppliers ( 137)
Supplier Tel Email Country ProdList Advantage
Shanghai Kangluo New Material Technology Co., LTD 021-021-51601195 19512239872 180800400@qq.com China 140 58
Shanghai Likas Industrial Co., LTD 19821976800 chinalikas@163.com China 457 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Supplier Advantage
Shanghai Kangluo New Material Technology Co., LTD 58
Shanghai Likas Industrial Co., LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Shanghai Hanhong Scientific Co.,Ltd. 64
Shandong Xiya Chemical Co., Ltd 57
Syntechem Co.,Ltd 57

View Latest Price from 1,3-Dioxane manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1,3-DIOXANE pictures 2026-09-02 1,3-DIOXANE
505-22-6
 $1.00-50.00 1KG 99% Henan Fengda Chemical Co., Ltd
1,3-Dioxane pictures 2026-05-28 1,3-Dioxane
505-22-6
 $10.70 10kg 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
1,3-Dioxane 97% pictures 2021-07-02 1,3-Dioxane 97%
505-22-6
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
  • 1,3-DIOXANE pictures
  • 1,3-DIOXANE
    505-22-6
  • $1.00-50.00
  • 99%
  • Henan Fengda Chemical Co., Ltd
  • 1,3-Dioxane pictures
  • 1,3-Dioxane
    505-22-6
  • $10.70
  • 99%
  • Hebei Chuanghai Biotechnology Co,.LTD
  • 1,3-Dioxane 97% pictures
  • 1,3-Dioxane 97%
    505-22-6
  • $10.00-15.00
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

1,3-Dioxane Spectrum

1,3-DIOXANE(505-22-6)MS1,3-DIOXANE(505-22-6)1HNMR1,3-DIOXANE(505-22-6)13CNMR1,3-DIOXANE(505-22-6)IR11,3-DIOXANE(505-22-6)Raman

505-22-6 (1,3-Dioxane) Related Search:

1-(1,4-Benzodioxane-2-carbonyl)piperazine 1,2:3,5-Di-O-isopropylidene-alpha-D-xylofuranose 3,9-Divinyl-2,4,8,10-tetraoxaspiro[5.5]undecane 2,2,5-Trimethyl-1,3-dioxane-4,6-dione 2-(1,3-Dioxan-2-yl)ethyltriphenylphosphonium bromide
1,4-Cyclohexanedione mono(2,2-dimethyltrimethylene ketal) Glycerol formal 4,6-O-Ethylidene-alpha-D-glucose 2-(2-Bromoethyl)-1,3-dioxane 1,3-Dioxan-2-one
2,2-Dimethyl-1,3-dioxane-4,6-dione 1,3-Dioxane Methyl 4,6-O-benzylidene-alpha-D-glucopyranoside 2,4,8,10-Tetraoxaspiro[5.5]undecane 5,5-Dimethyl-1,3-dioxan-2-one
4-Methyl-1,3-dioxane 2,2-Dimethyl-5-phenyl-1,3-dioxane-4,6-dione 4-Phenyl-1,3-dioxane

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1,3-Propanediol formal 1,3-propanediolformal dihydro-m-dioxi m-Dioxin, dihydro- meta-dioxane trimethyleneglycolmethyleneether M-DIOXANE 1,3-DIOXANE(M-) 1,3-DIOXANE (M-) 98+% FORMALDEHYDE TRIMETHYLENE ACETAL Trimethylene formal Trimethylene methylene dioxide 1,3-Dioxane,97% 1,3-Dioxane 97% 1,3-Dioxane> 1,3-Dioxacyclohexane 1,3-Dioxane 505-22-6 Oxygen Compounds Acetals/Ketals/Ortho Esters Organic Building Blocks Building Blocks Dioxanes Dioxanes & Dioxolanes Dioxanes Dioxanes & Dioxolanes