Benznidazole
- CAS No.
- 22994-85-0
- Chemical Name:
- Benznidazole
- Synonyms
- Benznidazol;ro71051;radanil;Rochagan;Aids007909;NSC 299972;Ro 07-1051;Aids-007909;benznidazole;Benzonidazol
- CBNumber:
- CB9390906
- Molecular Formula:
- C12H12N4O3
- Molecular Weight:
- 260.25
- MDL Number:
- MFCD00243089
- MOL File:
- 22994-85-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 189-192 °C (lit.) |
|---|---|
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | methanol: soluble50mg/mL, clear, colorless to yellow |
| pka | 14+-.0.46(Predicted) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | 0.4g/L(temperature not stated) |
| Merck | 13,1085 |
| BCS Class | 3 |
| InChI | 1S/C12H12N4O3/c17-11(14-8-10-4-2-1-3-5-10)9-15-7-6-13-12(15)16(18)19/h1-7H,8-9H2,(H,14,17) |
| InChIKey | CULUWZNBISUWAS-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1nccn1CC(=O)NCc2ccccc2 |
| FDA UNII | YC42NRJ1ZD |
| ATC code | P01CA02 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NI3340000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
Benznidazole price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 419656 | N-Benzyl-2-nitro-1H-imidazole-1-acetamide 97% | 22994-85-0 | 1g | $288 | 2026-04-30 | Buy |
| Cayman Chemical | 29090 | Benznidazole ≥95% | 22994-85-0 | 25mg | $117 | 2026-04-30 | Buy |
| Cayman Chemical | 29090 | Benznidazole ≥95% | 22994-85-0 | 50mg | $218 | 2026-04-30 | Buy |
| Cayman Chemical | 29090 | Benznidazole ≥95% | 22994-85-0 | 100mg | $388 | 2026-04-30 | Buy |
| Cayman Chemical | 29090 | Benznidazole ≥95% | 22994-85-0 | 250mg | $796 | 2026-04-30 | Buy |
Benznidazole Chemical Properties, Uses, Production
Description
Benznidazole is the second of the drugs approved for treatment of Chagas' disease. Like nifurtimox, it is effective against the circulating form of Trypanosoma cruzi during the acute phase of the disease, but also like nifurtimox, it is ineffective during the chronic stage of the disease.
Description
Benznidazole is an orally bioavailable antiprotozoal agent. It is a 2-nitroimidazole prodrug that becomes active when the nitro group is reduced within the parasite. It inhibits the growth of the parasites T. cruzi, T. vaginalis, G. lamblia, and E. histolytica (IC50s = 8.1, 18.62, 22.58, and 4.27 μM, respectively). It also inhibits clonogenic growth of human C33A cervical and KNS42 glioblastoma cancer cells under hypoxic, but not normoxic, conditions when used at a concentration of 100 μM. Benznidazole (100 mg/kg per day) decreases T. cruzi blood parasitemia to below detectable levels in a mouse model of chronic stable Chagas disease. Formulations containing benznidazole have been used in the treatment of Chagas disease caused by T. cruzi.
Uses
N-Benzyl-2-nitro-1H-imidazole-1-acetamide (Benznidazole) may be used as reference drug for the extraction of guaianolide from the aerial parts of Tanacetum parthenium and to evaluate its in vitro antiprotozoal activity.
Uses
Benznidazole (BNZ) is traditionally used to treat Chagas disease caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, Nifurtimox and Benznidazole, are toxic and present sever e side effects.
Definition
ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.
Antimicrobial activity
It exhibits antiprotozoal activity, particularly against Trypanosoma cruzi.
General Description
N-Benzyl-2-nitro-1H-imidazole-1-acetamide (Benznidazole) is a nitro-heterocyclic compound. It is widely employed drug for the treatment of Chagas disease. It exhibits three polymorphic forms..
Pharmaceutical Applications
A synthetic 2-nitroimidazole, formulated for oral administration. Solubility in water 400 mg/L.
Mechanism of action
Studies suggest that benznidazole does not catalyze the formation of ROS and, therefore, has a mechanism of action different from that of nifurtimox. It has been proposed that benznidazole undergoes an one-electron transfer to the nitro group, which in turn dismutates to give back the nitroimidazole and a nitrosoimidazole. The latter product may then undergo an electrophilic addition to trypanothione, which leads to depletion of trypanothione, an essential enzyme system in the Trypanosoma cruzi.
Pharmacokinetics
Oral bioavailability :High
Cmax 100 mg oral ：2.2–2.8 mg/L after 3–4 h
Plasma half-life：10.5–13.6 h
Volume of distribution：c. 0.56 L/kg
Plasma protein binding： c. 44%
The 2-nitro group undergoes reduction to the amine and hydrolysis to the hydroxy derivative.
Clinical Use
N-Benzyl-2-nitroimidazole-1-acetamide (Radanil, Rochagan)is a nitroimidazole derivative that is used for the treatment ofChagas disease. It is not available in the United States but isused extensively in South America. The effectiveness of benznidazoleis similar to that of nifurtimox. Therapy forAmerican trypanosomiasis with oral benznidazole requiresseveral weeks and is frequently accompanied by adverse effectssuch as peripheral neuropathy, bone marrow depression,and allergic-type reactions.
Clinical Use
Benznidazole is used in treatment of South American trypanosomiasis (Chagas disease).
Side effects
Adverse effects are more common in the elderly and include nausea, vomiting, abdominal pain, peripheral neuropathy and severe skin reactions.
References
[1] SHILPI KHARE. Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease.[J]. Antimicrobial Agents and Chemotherapy, 2015: 6385-6394. DOI: 10.1128/aac.00689-15
[2] ANDREA TROCHINE. Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics.[J]. PLoS Neglected Tropical Diseases, 2014, 8 5: e2844. DOI: 10.1371/journal.pntd.0002844
[3] JULIANA COGO . Trypanocidal activity of guaianolide obtained from Tanacetum parthenium (L.) Schultz-Bip. and its combinational effect with benznidazole[J]. Phytomedicine, 2012, 20 1: Pages 59-66. DOI: 10.1016/j.phymed.2012.09.011
[4] EMANUEL HERNáNDEZ-NúEZ. Design, Synthesis and Biological Evaluation of 2-(2-Amino-5(6)-nitro-1H-benzimidazol-1-yl)-N-arylacetamides as Antiprotozoal Agents.[J]. Molecules, 2017. DOI: 10.3390/molecules22040579
[5] QUHUAN LI Z Y Q Lin. Hypoxia-activated cytotoxicity of benznidazole against clonogenic tumor cells[J]. Cancer Biology & Therapy, 2016, 17 1: 1266-1273. DOI: 10.1080/15384047.2016.1250988
Benznidazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 984 | 62 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 4000 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from Benznidazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | Benznidazole
22994-85-0
|
1g | 99% | 5000kg | Jinan Jianfeng Chemical Co., Ltd | ||
 |
2026-07-20 | Benznidazol
22994-85-0
|
$31.00-64.00 | 99.83% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-03-12 | Benznidazole
22994-85-0
|
$25.00-35.00 | 1kg | 99.8% | 200tons/year | Sigma Audley |
-
- Benznidazole
22994-85-0
- 99%
- Jinan Jianfeng Chemical Co., Ltd
-
- Benznidazol
22994-85-0
- $31.00-64.00
- 99.83%
- TargetMol Chemicals Inc.
-
- Benznidazole
22994-85-0
- $25.00-35.00
- 99.8%
- Sigma Audley
