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Oxygen-fluorine acid

Oxygen-fluorine acid structure

CAS No.: 82419-35-0

Chemical Name:: Oxygen-fluorine acid

Synonyms: OFLOXACIN Q ACID;Ofloxacin Carboxylic Acid;9,10-DIFLUORO-3-METHYL-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC ACID;9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZ-OXAZINE-6-CARBOXYLIC ACID;Ofloxacin-1;AURORA 21894;Olfoxacin Acid;Oxygen-fluorine;Oxyfluoride acid;AKOS BBS-00001807

CBNumber:: CB9427004

Molecular Formula:: C13H9F2NO4

Molecular Weight:: 281.21

MDL Number:: MFCD00226106

MOL File:: 82419-35-0.mol

MSDS File:: SDS

Last updated:2026-05-28 04:30:35

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Oxygen-fluorine acid Properties

Melting point	320-322 °C (lit.)
Boiling point	459.2±45.0 °C(Predicted)
Density	1.61±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO (Slightly, Heated)
pka	4.87±0.40(Predicted)
form	solid
color	Off-White
BRN	4202751
InChI	1S/C13H9F2NO4/c1-5-4-20-12-9(15)8(14)2-6-10(12)16(5)3-7(11(6)17)13(18)19/h2-3,5H,4H2,1H3,(H,18,19)
InChIKey	NVKWWNNJFKZNJO-UHFFFAOYSA-N
SMILES	CC1COc2c(F)c(F)cc3C(=O)C(=CN1c23)C(O)=O
CAS DataBase Reference	82419-35-0(CAS DataBase Reference)
FDA UNII	501W86694Z
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
HS Code	29349990
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3
REACH Registrations	Active

Oxygen-fluorine acid price More Price(45)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2234	Ofloxacin Impurity A certified reference material, pharmaceutical secondary standard	82419-35-0	100mg	$494	2026-04-30	Buy
Sigma-Aldrich	472670	9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid 97%	82419-35-0	5g	$72	2026-04-30	Buy
TCI Chemical	O0404	9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid >98.0%(HPLC)	82419-35-0	5g	$65	2026-04-30	Buy
TCI Chemical	O0404	9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid >98.0%(HPLC)	82419-35-0	25g	$226	2026-04-30	Buy
Usbiological	009538	9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid\|(RS-Ofloxacin Carboxylic Acid)	82419-35-0	1g	$425	2026-06-03	Buy

Product number	Packaging	Price	Buy
PHR2234	100mg	$494	Buy
472670	5g	$72	Buy
O0404	5g	$65	Buy
O0404	25g	$226	Buy
009538	1g	$425	Buy

Oxygen-fluorine acid Chemical Properties, Uses, Production

Chemical Properties

Grey-Yellow Powder

Uses

9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid (Ofloxacin EP Impurity A) is an Ofloxacin intermediate.

General Description

(S)-(-)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid may be used in the preparation of the following:

kynurenine aminotransferase II (KAT II) inhibitor, [(S)-(-)-9-(4-aminopiperazine-1-yl)-8-fluoro-3-methyl-6-oxo-2,3,5,6-tetrahydro-4H-1-oxa-3a-aza-phenalene-5-carboxylic acid]
fused-ring derivatives
N-desmethyllevofloxacin

Synthesis

Benzenepropanoic acid, α-[[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-methylethyl]amino]methylene]-3,4,5-trifluoro-2-nitro-β-oxo-, ethyl ester, (E)- (9CI)

178233-30-2

429-41-4

82419-35-0

Example 1: Preparation of 9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid (I). 220 mg (0.447 mmol) of ethyl 2-(2-nitro-3,4,5-trifluorobenzoyl)-3-(1-tert-butyldimethylsilylmethoxypropan-2-ylamino)acrylate (II) was dissolved in 10 mL of tetrahydrofuran and the solution was cooled to 0 °C. To this solution 0.41 g (1.56 mmol) of tetrabutylammonium fluoride in tetrahydrofuran was added dropwise and stirred for 30 min. Subsequently, the reaction mixture was heated to reflux for 30 minutes. 2 mL of 10% aqueous potassium hydroxide solution was added and refluxing was continued for 30 minutes. After cooling to room temperature, the reaction mixture was filtered to remove insoluble material. The filtrate was concentrated under reduced pressure (25 °C/10 mmHg) and 20 mL of water was added to the residue. The aqueous phase was washed once with 5 mL of chloroform and then the pH was slowly adjusted to 3 with 1 N hydrochloric acid solution. the precipitate was collected by filtration, washed sequentially with 5 mL of water and 5 mL of a mixture of ethanol and ether (1:4, v/v/v), and dried to give 108 mg of the target product (86% yield). The melting point of the product was 308 °C (decomposition); NMR (TFA-d1) δ ppm: 9.39 (1H, s), 8.10 (1H, dd, J = 10.8 Hz), 5.11-5.26 (1H, m), 4.79 (1H, dd, J = 2.12 Hz), 4.65 (1H, dd, J = 2.12 Hz), 1.82 (3H, d. J = 6.7 Hz).

References

[1] Patent: US5952494, 1999, A

Oxygen-fluorine acid Preparation Products And Raw materials

Raw materials

Sodium hydride Ethyl 2,3,4,5-tetrafluorobenzoyl acetate Acetic anhydride Potassium hydroxide Triethyl orthoformate

DL-Alaninol Tetrahydrofuran Hydrochloric acid Dimethyl sulfoxide Benzenepropanoic acid, α-[[[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-methylethyl]amino]methylene]-3,4,5-trifluoro-2-nitro-β-oxo-, ethyl ester, (E)- (9CI)

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Preparation Products

Ofloxacin

Oxygen-fluorine acid Suppliers

Global Suppliers ( 295)

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Dexin Fine Chemical Co., Ltd.	18553366272	3091507995@qq.com	China	278	58
Jinan Daen Pharmaceutical Technology Co., Ltd	0531-68657833 15905416458	2098511197@qq.com	China	283	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Beijing dtftchem Technology Co., Ltd.	010-60275820 13031183356	elainezt@sina.com	China	1386	62
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50

Supplier	Advantage
Shandong Dexin Fine Chemical Co., Ltd.	58
Jinan Daen Pharmaceutical Technology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Beijing dtftchem Technology Co., Ltd.	62
Beijing HwrkChemical Technology Co., Ltd	55
Adamas Reagent, Ltd.	59
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50

View Latest Price from Oxygen-fluorine acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-18	Oxygen-fluorine acid 82419-35-0		1KG	98%min	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-02	Oxygen-fluorine acid 82419-35-0	$1.20-36.00	1kg	99%		Henan Fengda Chemical Co., Ltd
2025-06-20	Oxygen-fluorine acid 82419-35-0		1kg	98.50%	20tons	Hebei Yanxi Chemical Co., Ltd.

Oxygen-fluorine acid
82419-35-0
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Oxygen-fluorine acid
82419-35-0
$1.20-36.00
99%
Henan Fengda Chemical Co., Ltd

Oxygen-fluorine acid
82419-35-0
$0.00
98.50%
Hebei Yanxi Chemical Co., Ltd.

Oxygen-fluorine acid Spectrum

Oxygen-fluorine acid(82419-35-0)IR

82419-35-0 (Oxygen-fluorine acid) Related Search:

Methyl salicylate Dihydromyrcenol 1-AdaMantanethylaMine Oxygen Ofloxacin

Levofloxacin Basic Violet 1 Methylparaben Tribenuron methyl Methyl acrylate

Kresoxim-methyl Methanol Levofloxacin carboxylic acid Piperazine 1-Piperazinecarbaldehyde

2,3,4,5-Tetrafluorobenzoyl chloride 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-amino-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)- (9CI) Methyl

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9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7h-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxyllic acid AURORA 21894 AKOS BBS-00001807 OXYGEN-FLUORINE ACID OTAVA-BB BB0111050010 9,10-Difluoro-2,3-Dihydro-3-Methyl-7-Oxo-7h-Pyroido(1,2,3-De)(1,4)Benzoxazine-6-Carboxylic Acid Oxygen fluorine acid(FPA) DIFLUOROCARBOYLIC ACID 9,10-DIFLUORO-2,3-DIHYDRO-3-ME-7-OXO-7H- PYRIDO(1,2,3-DE)1,4-BENZOXAZINE-6-COOH 9,10-Difluoro-3-Methyl-7-Oxo-2,3-Dihydro 7-H-Pyrido-1,2,3-DE]-1,4-Benzoxyazine-6-Carboxylic Acid Oxygen-fluorine 9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylicacid 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3de]-1,4-benzoxazine 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic (RS)-9,10-Difluro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid (FPA) 9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Ofloxacin Impurity 4(Ofloxacin EP Impurity A) 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid (RS-Ofloxacin Carboxylic Acid) Ofloxacin EP IMpurity A (RS)-9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-DE]-1,4-benz-oxazine-6-carboxylic acid ,97% 9,10-difluoro-2,3-dihydro-3-me-7-oxo-7h-pyrido-1, Oxygen-fluorine acid ,98% 9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBO 7H-PYRIDO[1,2,3-DE]-1,4-BENZOXAZINE-6-CARBOXYLICACID,9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO Olfoxacin Acid Ofloxacin Impurity A(EP) Ofloxacin-1 Levofloxacin Hydrochloride ImpurityⅡ: Impurity A(9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid(RS-Ofloxacin Carboxylic Acid)) Ofloxacin Carboxylic Acid 6,7-Difluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.0^{5,13}]trideca-5(13),6,8,11-tetraene-11-carboxylic acid RS-Ofloxacin Carboxylic Acid 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicAcid> Ofloxacin impurity A CRS (RS)-9,10-Difluoro-3-methyl-7-oxo-2 (+/-)9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]lbenzoxazine-6-carboylic acid Ofloxacin EP Impurity A (Ofloxacin Difluoro Carboxylic Acid) Ofloxacin impurity A (O0120010) Levofloxacin Hydrochloride ImpurityⅡ: Impurity A(9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid_x000b_(RS-Ofloxacin Carboxylic Acid)) Oxygen-fluorineacid Ethambutol dihydrochloride (RS)-9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid 9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (RS)-9,10-Difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid (FPA) Ofloxacin Imp. A (EP): (3RS)-9,10-difluoro-3-methyl -7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid 9,10-Difl/1/3/9/7/1/5/1/4/0/0/7/uoro-3-Methyl-7-Oxo- Levofloxacin Hydrochloride ImpurityⅡ: Impurity A(9,10-Difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid(RS-Ofloxacin Carboxylic Acid)) Oxyfluoride acid 9,10-DIFLUORO-3-METHYL-7-OXO-2,3-DIHYDRO-7H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6-CARBOXYLIC ACID 9,10-DIFLUORO-2,3-DIHYDRO-3-METHYL-7-OXO-7H-PYRIDO[1,2,3-DE]-1,4-BENZ-OXAZINE-6-CARBOXYLIC ACID OFLOXACIN Q ACID 82419-35-0 C13H9F2NO4 C13H8F2NO4 Heterocyclic Building Blocks Benzoxazines Building Blocks Various Intermediates Intermediates