SENKIRKIN
- CAS No.
- 2318-18-5
- Chemical Name:
- SENKIRKIN
- Synonyms
- Kushenin;SENKIKIN;renardin;SENKIRKIN;nsc-89945;RENARIDINE;Senkarkane;senkirkine;renardine[neutral];Renardine (neutral)
- CBNumber:
- CB9427741
- Molecular Formula:
- C19H27NO6
- Molecular Weight:
- 365.42
- MDL Number:
- MFCD01684247
- MOL File:
- 2318-18-5.mol
- MSDS File:
- SDS
| Melting point | 197°C |
|---|---|
| Boiling point | 497.19°C (rough estimate) |
| Density | 1.2439 (rough estimate) |
| refractive index | 1.5180 (estimate) |
| storage temp. | -20°C |
| pka | 12.67±0.40(Predicted) |
| form | Solid |
| color | White to off-white |
| LogP | 0.690 (est) |
| EWG's Food Scores | 1 |
| FDA UNII | X65P7V4LVJ |
| IARC | 3 (Vol. 31, Sup 7) 1987 |
SENKIRKIN price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL89274 | Senkirkine phyproof? Reference Substance | 2318-18-5 | 10MG | $760 | 2026-04-30 | Buy |
| Usbiological | 020896 | Senkirkine | 2318-18-5 | 1mg | $523 | 2026-06-03 | Buy |
| Biosynth | FS161626 | Senkirkine | 2318-18-5 | 1mg | $155.76 | 2026-06-04 | Buy |
| Biosynth | FS161626 | Senkirkine | 2318-18-5 | 2mg | $259.6 | 2026-06-04 | Buy |
| Biosynth | FS161626 | Senkirkine | 2318-18-5 | 5mg | $545.15 | 2026-06-04 | Buy |
SENKIRKIN Chemical Properties, Uses, Production
Description
A further hepatotoxiC alkaloid present in Senecio kirkii Hook, S. renardi and Nardosrnia laevigata. The base has [α]25D - 16° (c 1.89, MeOH) or[α]15D - 6.2° (c 1.91, CHCI3). It forms colourless plates when crystallized from either Me2CO or AcOEt and yields a picrate, m.p. 225.5-226°C and a picrolonate, m.p. 109- 110°C. The ultraviolet spectrum shows a single absorption maximum at 219 mp.. Several crystalline salts and derivatives are known, e.g. the aurichloride, m.p. 182.5-183.5°C; platinichloride, m.p. 196-7°C (dec.); bitartrate, m.p. 201°C; reineckate, m.p. 169-171°C; picrate, m.p. 225- 225.5°C; picrolonate, m.p. 138°C and the methiodide, m.p. 194-6°C (dec.). The O-acetate occurs naturally (q.v.) in Senecio kirkii.
Uses
Senkirkin, a pyrrolizidine alkaloid, occured in the aerial parts of the medicinal plant Tussilago farfara, could induce chromosome damage in human lymphocytes. Senkirkin can be metabolized by CYP3A4[1].
Definition
ChEBI: Senkirkine is a macrolide.
Safety Profile
Poison by ingestion and intraperitoneal routes. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Nox
References
Briggs, Mangan, Russell., J. Chern. Soc., 1891 (1948)
Massagetov, Kuzovkov.,J. Gen. Chern., USSR, 23, 158 (1953)
Danilova, Konovalova., ibid, 30, 1921 (1961)
Danilova, Koretskaya, Utkin., ibid, 31, 3815 (1961)
Wunderlich., Chern. Ind., 2089 (1962)
Briggs et al., J. Chern. Soc., 2492 (1965)
SENKIRKIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| RENI Pharmaceutical Technology Co., Ltd | 028-87865381 18108190480 | 3961643053@qq.com | China | 4321 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| XI'AN KPC-CN BIOLOGICAL TECHNOLOGY CO.,LTD. | 86-029-85456576 | daisy_wang@vip.163.com | China | 292 | 55 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6904 | 55 |
| Biyu Biotechnology (Shanghai) Co., ltd | 021-26018599 | China | 269 | 56 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
