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3-Chloro-6-methoxypyridazine

3-Chloro-6-methoxypyridazine Structure
3-Chloro-6-methoxypyridazine structure
CAS No.
1722-10-7
Chemical Name:
3-Chloro-6-methoxypyridazine
Synonyms
NSC 69819;NSC 522667;TIMTEC-BB SBB004124;SPECS AC-907/25014054;3-Chloro-6-methoxypyrazine;6-Chloro-3-methoxypyridazine;3-Methoxy-6-chloropyridazine;3-Chloro-6-methoxypyridazine;3-Chloro-6-methoxy-1,2-diazine;pyridazine, 3-chloro-6-methoxy-
CBNumber:
CB9437764
Molecular Formula:
C5H5ClN2O
Molecular Weight:
144.56
MDL Number:
MFCD00006467
MOL File:
1722-10-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:56:28
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3-Chloro-6-methoxypyridazine Properties

Melting point 84-85 °C(lit.)
Boiling point 285℃
Density 1.292
Flash point 126℃
storage temp. Inert atmosphere,Room Temperature
form powder to crystal
pka 0.74±0.10(Predicted)
color White to Almost white
BRN 118854
InChI InChI=1S/C5H5ClN2O/c1-9-5-3-2-4(6)7-8-5/h2-3H,1H3
InChIKey XBJLKXOOHLLTPG-UHFFFAOYSA-N
SMILES C1(Cl)=NN=C(OC)C=C1
CAS DataBase Reference 1722-10-7(CAS DataBase Reference)
FDA UNII 4NE4MDH8HE
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  3
HazardClass  IRRITANT
HS Code  2933998090
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

3-Chloro-6-methoxypyridazine price More Price(62)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 108596 3-Chloro-6-methoxypyridazine 95% 1722-10-7 5g $111 2023-01-07 Buy
TCI Chemical C2376 3-Chloro-6-methoxypyridazine >97.0%(GC) 1722-10-7 5g $67 2026-04-30 Buy
TCI Chemical C2376 3-Chloro-6-methoxypyridazine >97.0%(GC) 1722-10-7 25g $265 2026-04-30 Buy
ChemScene CS-W001168 3-Chloro-6-methoxypyridazine ≥95% 1722-10-7 5g $9 2026-06-04 Buy
ChemScene CS-W001168 3-Chloro-6-methoxypyridazine ≥95% 1722-10-7 25g $18 2026-06-04 Buy
Product number Packaging Price Buy
108596 5g $111 Buy
C2376 5g $67 Buy
C2376 25g $265 Buy
CS-W001168 5g $9 Buy
CS-W001168 25g $18 Buy

3-Chloro-6-methoxypyridazine Chemical Properties, Uses, Production

Uses

3-Chloro-6-methoxypyridazine was used in the preparation of number of α-aryl-α-(pyridazin-3-yl)-acetonitriles.

Synthesis Reference(s)

The Journal of Organic Chemistry, 60, p. 1466, 1995 DOI: 10.1021/jo00110a059

General Description

3-Chloro-6-methoxypyridazine undergoes regioselective metallation using various lithium alkylamides, temperatures and solvents (THF and ether). It was lithiated using lithium 2,2,6,6-tetramethylpiperidide during the synthesis of minaprine.

Synthesis

3,6-Dichloropyridazine

141-30-0

Sodium Methoxide

124-41-4

3-CHLORO-6-METHOXYPYRIDAZINE

1722-10-7

A methanolic solution of 0.5 M sodium methanolate (NaOMe/MeOH, 7.4 mL, 3.69 mmol) was slowly added dropwise to a solution of anhydrous tetrahydrofuran (12 mL) containing 3,6-dichloropyridazine (500 mg, 3.36 mmol), and the reaction mixture was stirred for 1 h at room temperature. Subsequently, the reaction was quenched by the addition of water. The reaction mixture was extracted with ethyl acetate and the organic phases were combined. The organic phase was washed with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography to afford 6-methoxy-3-chloropyridazine (436 mg, 90% yield) as a white solid.1H NMR (400 MHz, CDCl3) δ 4.12 (s, 3H), 6.98 (d, J = 9.2 Hz, 1H), 7.38 (d, J = 9.2 Hz, 1H); 13C NMR (100 MHz, CDCl3) δ 55.5 (d, J = 9.2 Hz, 1H). CDCl3) δ 55.2, 119.9, 130.6, 150.9, 164.2.

References

[1] Journal of Heterocyclic Chemistry, 2005, vol. 42, # 4, p. 509 - 513
[2] Patent: US2010/261727, 2010, A1. Location in patent: Page/Page column 31
[3] ACS Chemical Neuroscience, 2017, vol. 8, # 11, p. 2374 - 2380
[4] Journal of Heterocyclic Chemistry, 2013, vol. 50, # 5, p. 1165 - 1173
[5] Journal of the American Chemical Society, 1959, vol. 81, p. 6511,6512

3-Chloro-6-methoxypyridazine Preparation Products And Raw materials

Raw materials

3,6-Dichloropyridazine Sodium Methoxide

Preparation Products

(6-Methoxypyridazin-3-yl)methanol 3-methoxy-6-(6-methoxypyridin-3-yl)pyridazine 3-methoxy-6-(1-piperazinyl)Pyridazine 3-Hydrazinyl-6-methoxypyridazine

3-Chloro-6-methoxypyridazine Suppliers

Global Suppliers ( 197)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Jia Xing Isenchem Co.,Ltd 66
Accela ChemBio Co.,Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shandong Xiya Chemical Co., Ltd 57

View Latest Price from 3-Chloro-6-methoxypyridazine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Chloro-6-methoxypyridazine pictures 2026-09-02 3-Chloro-6-methoxypyridazine
1722-10-7
 $1.00-200.00 1KG 99%, 99.5% Sublimated Henan Fengda Chemical Co., Ltd
3-CHLORO-6-METHOXYPYRIDAZINE pictures 2026-08-20 3-CHLORO-6-METHOXYPYRIDAZINE
1722-10-7
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
3-Chloro-6-methoxypyridazine pictures 2022-01-04 3-Chloro-6-methoxypyridazine
1722-10-7
 1g 98%minHPLC 300kgs/month Shanghai Rlavie Technology Co ltd

3-Chloro-6-methoxypyridazine Spectrum

3-CHLORO-6-METHOXYPYRIDAZINE(1722-10-7)1HNMR3-CHLORO-6-METHOXYPYRIDAZINE(1722-10-7)13CNMR3-CHLORO-6-METHOXYPYRIDAZINE(1722-10-7)IR13-CHLORO-6-METHOXYPYRIDAZINE(1722-10-7)IR23-CHLORO-6-METHOXYPYRIDAZINE(1722-10-7)Raman

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SPECS AC-907/25014054 TIMTEC-BB SBB004124 3-Methoxy-6-chloropyridazine 6-Chloro-3-methoxypyridazine pyridazine, 3-chloro-6-methoxy- 3-Chloro-6-methoxypyridazine,97% NSC 522667 NSC 69819 3-Chloro-6-methoxy-1,2-diazine 3-Chloro-6-methoxypyridazine 95% JR-8338, 3-Chloro-6-methoxypyridazine, 97% 3-Chloro-6-methoxypyridazine > 3-Chloro-6-methoxypyrazine 3-CHLORO-6-METHOXYPYRIDAZINE ISO 9001：2015 REACH 3-Chloro-6-methoxypyridazine 1722-10-7 HETERO CHLORIDE Building Blocks Heterocyclic Building Blocks Halogenated Heterocycles Pyridazines Pyridines, Pyrimidines, Purines and Pteredines Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridazines PyridazinesHeterocyclic Building Blocks