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Ethyl S-4-chloro-3-hydroxybutyrate

Ethyl S-4-chloro-3-hydroxybutyrate Structure
Ethyl S-4-chloro-3-hydroxybutyrate structure
CAS No.
86728-85-0
Chemical Name:
Ethyl S-4-chloro-3-hydroxybutyrate
Synonyms
ETHYL (S)-4-CHLORO-3-HYDROXYBUTANOATE;ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE;ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTYRATE;SECHB;AST-4;PEFC-026;(S)-(?)-4-chL;(S)-Ethyl 4-chloro-3-;oro-3-hydroxybutyrate;4-chloro-3-hydroxyhexanoate
CBNumber:
CB9448087
Molecular Formula:
C6H11ClO3
Molecular Weight:
166.6
MDL Number:
MFCD00211241
MOL File:
86728-85-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 04:52:33
Request For Quotation

Ethyl S-4-chloro-3-hydroxybutyrate Properties

alpha -14.5 º (c=neat)
Boiling point 93-95 °C5 mm Hg(lit.)
Density 1.19 g/mL at 25 °C(lit.)
refractive index n20/D 1.453(lit.)
Flash point 109 °C
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Liquid
pka 13.23±0.20(Predicted)
color Clear colorless to yellow
optical activity [α]23/D 14°, neat
BRN 4657170
InChI InChI=1S/C6H11ClO3/c1-2-10-6(9)3-5(8)4-7/h5,8H,2-4H2,1H3/t5-/m0/s1
InChIKey ZAJNMXDBJKCCAT-YFKPBYRVSA-N
SMILES C(OCC)(=O)C[C@H](O)CCl
CAS DataBase Reference 86728-85-0(CAS DataBase Reference)
UNSPSC Code 12352101
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H318
Precautionary statements  P280-P305+P351+P338
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,Xn
Risk Statements  41-22
Safety Statements  26-36-39
RIDADR  2810
WGK Germany  3
HazardClass  6.1
PackingGroup  III
HS Code  29181990
Storage Class 10 - Combustible liquids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
NFPA 704
0
2 0

Ethyl S-4-chloro-3-hydroxybutyrate price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 460524 Ethyl (S)-(?)-4-chloro-3-hydroxybutyrate 96% 86728-85-0 1g $42.5 2026-04-30 Buy
Sigma-Aldrich 460524 Ethyl (S)-(?)-4-chloro-3-hydroxybutyrate 96% 86728-85-0 5g $79.9 2026-04-30 Buy
TCI Chemical C1717 Ethyl (S)-4-Chloro-3-hydroxybutyrate >95.0%(GC) 86728-85-0 5g $40 2026-04-30 Buy
TCI Chemical C1717 Ethyl (S)-4-Chloro-3-hydroxybutyrate >95.0%(GC) 86728-85-0 25g $72 2026-04-30 Buy
Biosynth FE60199 Ethyl (S)-4-chloro-3-hydroxybutyrate 86728-85-0 50g $900 2026-06-04 Buy
Product number Packaging Price Buy
460524 1g $42.5 Buy
460524 5g $79.9 Buy
C1717 5g $40 Buy
C1717 25g $72 Buy
FE60199 50g $900 Buy

Ethyl S-4-chloro-3-hydroxybutyrate Chemical Properties,Uses,Production

Chemical Properties

Colorless to light yellow liqui

Uses

Atorvastatin Intermediate

Uses

Ethyl (S)-()-4-chloro-3-hydroxybutyrate can be used as a starting material in the synthesis of 4-amino-3-hydroxybutyric acid, a compound of pharmacological importance.

Biosynthesis

Bioreductions catalyzed by alcohol dehydrogenases (ADHs) play an essential role in synthesizing chiral alcohols. A novel ADH, SmADH31, obtained from the Stenotrophomonas maltophilia genome, which can tolerate extremely high concentrations (6 M) of both substrate and product. The coexpression of SmADH31 and glucose dehydrogenase from Bacillus subtilis in Escherichia coli meant that as much as 660 g L–1 (4.0 M) ethyl 4-chloroacetoacetate was completely converted into ethyl (S)-4-chloro-3-hydroxybutyrate [(S)-CHBE] in a monophasic aqueous system with a >99.9% ee value and a high space-time yield (2664 g L–1 d–1). In the 100 ml-scale monophasic aqueous system (in triplicate), 66.0 g COBE (single batch charge) can be completely converted to (S)-CHBE (ee >99.9%) in only 6 h with 2 g of the SmADH31/GDH co-expressing cells. After extraction and evaporation, 61.6 g (S)-CHBE was isolated with 92% yield[1].

General Description

Ethyl (S)-4-chloro-3-hydroxybutanoate is a chiral intermediate generally used to prepare atorvastatin, a cholesterol-lowering drug.

References

[1] Zeyu Yang. “Efficient Asymmetric Synthesis of Ethyl (S)-4-Chloro-3-hydroxybutyrate Using Alcohol Dehydrogenase SmADH31 with High Tolerance of Substrate and Product in a Monophasic Aqueous System.” Organic Process Research & Development 24 6 (2020): 1068–1076.

Ethyl S-4-chloro-3-hydroxybutyrate Preparation Products And Raw materials

Raw materials

(S)-(+)-Epichlorohydrin Ethyl 4-chloroacetoacetate Ethanol Butanoic acid, 4-chloro-3-hydroxy-, (3S)- carbon monoxide
Hydrogen

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Preparation Products

Ethyl S-4-chloro-3-hydroxybutyrate Suppliers

Global( 474)Suppliers
Supplier Tel Email Country ProdList Advantage
TaiZhou ZhiCheng Chemicals & Technology Co., LTD. 0523-82837785 13914525028 info@jszchg.com China 244 60
Hangzhou XunDa Bio-Technology Co., Ltd. 0571-86932585 18067973930 xuandasales@163.com China 40 58
Hunan Xinbelai Biotechnology Co., LTD 18667946270 18667946270 wangzeren1@synbiolab.cn China 114 58
Hangzhou WDJBIO Co., Ltd. 0571-86706360 18158111080 3168409019@qq.com China 579 58
Jiangxi Sunway Chemical Co., Ltd. 15888611133; 18605760166 trade@jxswchem.com China 15 58
Hubei Peien Biotechnology Co., Ltd. 13127581762 13127581762 peilingchem@sina.com China 173 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
JIANGXI AIFEIMU TECHNOLOGY CO.,LTD 793-33899567 13735087952 sales@afmpharm.com China 51 61
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Supplier Advantage
TaiZhou ZhiCheng Chemicals & Technology Co., LTD. 60
Hangzhou XunDa Bio-Technology Co., Ltd. 58
Hunan Xinbelai Biotechnology Co., LTD 58
Hangzhou WDJBIO Co., Ltd. 58
Jiangxi Sunway Chemical Co., Ltd. 58
Hubei Peien Biotechnology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
JIANGXI AIFEIMU TECHNOLOGY CO.,LTD 61
Alfa Aesar 84

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View Lastest Price from Ethyl S-4-chloro-3-hydroxybutyrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl S-4-chloro-3-hydroxybutyrate pictures 2026-09-13 Ethyl S-4-chloro-3-hydroxybutyrate
86728-85-0
 0.99 RongNa Biotechnology Co.,Ltd
Ethyl S-4-chloro-3-hydroxybutyrate pictures 2026-09-02 Ethyl S-4-chloro-3-hydroxybutyrate
86728-85-0
 $3.00-8.00 1KG 99% Henan Fengda Chemical Co., Ltd
Ehyl-4-(-)chloro-3-hydroxybutyrate pictures 2026-08-08 Ehyl-4-(-)chloro-3-hydroxybutyrate
86728-85-0
 1KG 98% 1000 Hangzhou ICH Biofarm Co., Ltd

Ethyl S-4-chloro-3-hydroxybutyrate Spectrum

Ethyl S-4-chloro-3-hydroxybutyrate(86728-85-0)1HNMREthyl S-4-chloro-3-hydroxybutyrate(86728-85-0)IR

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ethyl()-4-chloro-3-hydroxybutanoate Ethyl(S)-4-chloro-3-hydroxybutylate S-4-Chloro-3-hydroxybutyrate ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTANOATE (-)-ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE BUTANOIC ACID, 4-CHLORO-3-HYDROXY-, ETHYL ESTER, (S) SECHB Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 97% 1GR )-4-chloro-3-hydroxybutyrate (S)-Ethyl 4-chloro-3- AST-4 Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate 96% Butanoic acid,4-chloro-3-hydroxy-, ethyl ester, (3S)- (S) - (-) - chlorine - 4-3 - hydroxy ethyl butyrate Ethyl (3S)-(-)-4-chloro-3-hydroxybutyrate (S)-(-)-ETHYL-4-CHLORO 3-HYDROXYBUTANOATE (S)-ETHYL 4-CHLORO-3-HYDROXYBUTYRATE (S)-(-)-4-CHLORO-3-HYDROXYBUTYRIC ACID ETHYL ESTER (S)-4-CHLORO-3-HYDROXYBUTYRIC ACID ETHYL ESTER Oxiracetam (S(-)-4-chloro-3-hydroxybutyric acid ethyl ester) (S)-4-CHLORO-3-HYDROXY-N-BUTYRIC ACID ETHYL ESTER Ehyl-4-(-)chloro-3-hydroxybutyrate Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 96% (97% EE/GLC) (2R,4R)-2,4-PENTANEDIOL EE 99+% Ethyl(S)-(-)-4-chloro-3-Hydrox ETHYL(S)-4-CHLORO-3-HYDROXY-BUTYRATE/ATS-4 ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTYRATE , EE 98% methyl 3S-4-chloro-3-hydroxybutanoate Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 98%, ee 98% Ethyl (3S)-4-chloro-3-hydroxybutanoate Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate,97% (S)-(-)-ethyl-4-chloro 3-hydroxybutanoate(ATS-4) Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 96%, ee 98% Ethyl S-4-chloro-3-hydroxybutyate 4-chloro-3-hydroxyhexanoate (S)-4-Chloro-3-Hydroxy-Butyric Acid Enthylester PEFC-026 Ethyl (S)-4-Chloro-3-hydroxybutyrate > (S)-(?)-4-chL oro-3-hydroxybutyrate Butanoic acid, 4-chloro-3-hydroxy-, ethyl ester, (3S)- (9CI, ACI) 4-chloro-3-hydroxy-Butanoic acid ethyl ester (3S)- (9CI ACI) (S)-4-Chloro-3-hydroxybutyric Acid Ethyl Ester(ATS-4) (3S)-4-Chloro-3-hydroxy-butanoic acid ethyl ester Ethyl-(S)-4 chloro-3-hydroxy-Butyrarte Ethyl-S-(-)chloro-3-hydroxybutyrate S (-) -4-chloro-3-hydroxybutyrate ethyl ester Ethyl (S)-(?)-4-chloro-3-hydroxybutyrate (S)-ethyl-4-chloro-6-hydroxybutanoate ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTYRATE ETHYL (S)-4-CHLORO-3-HYDROXYBUTANOATE ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE 86728-85-0 96728-85-0 C6H11ClO3 Organic Building Blocks Esters Asymmetric Synthesis