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2-Nitrobenzyl bromide

2-Nitrobenzyl bromide Structure
2-Nitrobenzyl bromide structure
CAS No.
3958-60-9
Chemical Name:
2-Nitrobenzyl bromide
Synonyms
1-(Bromomethyl)-2-nitrobenzene;2-Nitrobenzyl;LIXI-011;2-Benzyl bromide;o-Nitrobenaylbromide;2-Nitrobenzyl bromid;-Bromo-2-mitrotoluene;2-NITROBENZYL BROMIDE;NITROBENZYL-2 BROMIDE;O-NITROBENZYL BROMIDE
CBNumber:
CB9478950
Molecular Formula:
C7H6BrNO2
Molecular Weight:
216.03
MDL Number:
MFCD00007184
MOL File:
3958-60-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-04 16:00:12
Product description Number Pack Size Price
2-Nitrobenzyl bromide 98% 107794 5g $45.9
2-Nitrobenzyl bromide 98% 107794 25g $145
2-Nitrobenzyl Bromide >98.0%(GC) N0404 5g $34
2-Nitrobenzyl Bromide >98.0%(GC) N0404 25g $102
1-(Bromomethyl)-2-nitrobenzene TRC-B685690-5G 5g $72
More product size
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2-Nitrobenzyl bromide Properties

Melting point 44-46 °C (lit.)
Boiling point 265.51°C (rough estimate)
Density 1.6841 (rough estimate)
refractive index 1.6120 (estimate)
Flash point >230 °F
storage temp. Inert atmosphere,2-8°C
solubility Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form Crystals or Crystalline Powder
color Yellow to light brown
Water Solubility insoluble
BRN 638991
Stability Hygroscopic
InChI InChI=1S/C7H6BrNO2/c8-5-6-3-1-2-4-7(6)9(10)11/h1-4H,5H2
InChIKey HXBMIQJOSHZCFX-UHFFFAOYSA-N
SMILES C1(CBr)=CC=CC=C1[N+]([O-])=O
CAS DataBase Reference 3958-60-9(CAS DataBase Reference)
NIST Chemistry Reference 2-Nitrobenzyl bromide(3958-60-9)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H314-H335
Precautionary statements  P260-P280-P303+P361+P353-P305+P351+P338+P310
PPE Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  C
Risk Statements  34
Safety Statements  26-36/37/39-45
RIDADR  UN 3261 8/PG 2
WGK Germany  3
F  4.8-19-21
HazardClass  8
PackingGroup  II
HS Code  29049085
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Eye Dam. 1
Skin Corr. 1B
Limited Quantities 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
1
3 0

2-Nitrobenzyl bromide price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 107794 2-Nitrobenzyl bromide 98% 3958-60-9 5g $45.9 2026-04-30 Buy
Sigma-Aldrich 107794 2-Nitrobenzyl bromide 98% 3958-60-9 25g $145 2026-04-30 Buy
TCI Chemical N0404 2-Nitrobenzyl Bromide >98.0%(GC) 3958-60-9 5g $34 2026-04-30 Buy
TCI Chemical N0404 2-Nitrobenzyl Bromide >98.0%(GC) 3958-60-9 25g $102 2026-04-30 Buy
TRC TRC-B685690-5G 1-(Bromomethyl)-2-nitrobenzene 3958-60-9 5g $72 2026-06-03 Buy
Product number Packaging Price Buy
107794 5g $45.9 Buy
107794 25g $145 Buy
N0404 5g $34 Buy
N0404 25g $102 Buy
TRC-B685690-5G 5g $72 Buy

2-Nitrobenzyl bromide Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

2-Nitrobenzyl bromide is used in the preparation of S-2-nitrobenzyl-cysteine by reaction with L-cysteine. It is also used for the introduction of the 2-nitrobenzyl protecting group in organic synthesis. It plays an important role in the production of expectorant agent. Further, it is employed for caging unprotected cysteine-containing or thiophosphorylated peptides in aqueous solution. In addition to this, it is used in the preparation of (R)- and (S)-3-amino-3,4-dihydro-1H-quinolin-2-one.

Uses

2-Nitrobenzyl bromide was used for caging unprotected cysteine-containing or thiophosphorylated peptides in aqueous solution. It can be used in the synthesis of (R)- and (S)-3-amino-3,4-dihydro-1H-quinolin-2-one.

Biochem/physiol Actions

2-Nitrobenzyl bromide reacts with L-cysteine to form S-2-nitrobenzyl-cysteine which was used for modification of ultra-low-gelling-temperature (ULGT) agarose.

Synthesis

2-Nitrotoluene

88-72-2

2-Nitrobenzyl bromide

3958-60-9

In a 5000 L bromination reactor, 300 kg of dichloroethane, 226 kg of o-nitrotoluene and 27 kg of azobisisobutyronitrile were added sequentially. After stirring for 20 minutes, the mixed solution was transferred to a high tank and set aside; the bromination reactor was then refilled. To the reactor, 300 kg of dichloroethane and 226 kg of o-nitrotoluene were added, mixed thoroughly, then 889.03 kg of 40% hydrobromic acid was added, and the mixture was stirred at 72 to 75°C. The mixture was then transferred to the high tank and set aside for 20 minutes. From the high tank, the mixed solution was slowly added to the bromination reactor with 448.26 kg of 30% hydrogen peroxide at a 1:4 dropwise rate. After dropwise addition, the reaction was continued for 2 hours. After completion of the reaction, it was cooled to room temperature and analyzed by HPLC. The feedstock conversion was over 99.0% and no by-products such as dibrominated products were detected. The molar ratio of o-nitrotoluene, 40% hydrobromic acid and 30% hydrogen peroxide in the reaction was 1:1.2:1.2. After static partitioning, the upper aqueous phase was separated; the lower organic phase was washed with 600 L of water, and the solvent was removed by distillation under reduced pressure, and finally washed with cold dichloroethane to obtain a white 2-nitrobenzyl bromide solid product in 98.5% yield.

References

[1] Organic Process Research and Development, 1998, vol. 2, # 4, p. 261 - 269
[2] Patent: CN107778181, 2018, A. Location in patent: Paragraph 0008; 0028; 0029
[3] Patent: CN108440301, 2018, A. Location in patent: Page/Page column 0038-0058
[4] Patent: CN108203384, 2018, A. Location in patent: Paragraph 0022; 0023; 0024; 0025; 0026; 0027
[5] Patent: EP2308868, 2011, A1. Location in patent: Page/Page column 18

2-Nitrobenzyl bromide synthesis

88-72-2
3958-60-9
Synthesis of 2-Nitrobenzyl bromide from 2-Nitrotoluene

2-Nitrobenzyl bromide Preparation Products And Raw materials

Raw materials

2-Nitrotoluene AIBN Carbon tetrachloride 1-(Methoxymethyl)-2-nitrobenzene 2-Nitrobenzyl alcohol
Ammonium acetate Hydrogen peroxide Hydrogen bromide 1,2-Dichloroethane

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Preparation Products

2-NITRO-ALPHA-TOLUENESULFONYL CHLORIDE 2,3,4,5-TETRAHYDRO-1H-BENZO[E][1,4]DIAZEPINE Phenyl carbamate 2,2'-DINITRODIBENZYL

2-Nitrobenzyl bromide Suppliers

Global( 311)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 sales1@chuanghaibio.com China 5218 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21531 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8618017249410 jack.li@time-chemicals.com China 1796 55
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63645 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
career henan chemical co 		+86-0371-86658258 factory@coreychem.com China 29780 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 marketing1@neostarunited.com China 8827 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17339 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +86-189 4982 3763 sales@tnjchem.com China 34526 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1059@dideu.com China 29096 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co,.LTD 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Neostar United (Changzhou) Industrial Co., Ltd. 		58
SIMAGCHEM CORP 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Dideu Industries Group Limited 		58

View Lastest Price from 2-Nitrobenzyl bromide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Nitrobenzyl bromide pictures 2026-05-28 2-Nitrobenzyl bromide
3958-60-9
 $9.00 1KG 99.9 1 ton Hebei Chuanghai Biotechnology Co,.LTD
2-Nitrobenzyl bromide pictures 2025-04-04 2-Nitrobenzyl bromide
3958-60-9
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
2-Nitrobenzyl bromide pictures 2023-08-31 2-Nitrobenzyl bromide
3958-60-9
 $100.00 1kg 99 5000 Hebei Fengqiang Trading Co., LTD

2-Nitrobenzyl bromide Spectrum

2-Nitrobenzyl bromide(3958-60-9)MS2-Nitrobenzyl bromide(3958-60-9)1HNMR2-Nitrobenzyl bromide(3958-60-9)13CNMR2-Nitrobenzyl bromide(3958-60-9)IR12-Nitrobenzyl bromide(3958-60-9)Raman

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1-Bromomethyl-2-nitro-benzene Benzene, 1-(bromomethyl)-2-nitro- -Bromo-2-mitrotoluene o-Nitrobenaylbromide 2-NITROBENZYL BROMIDE 2-(BROMOMETHYL)NITROBENZENE A-BROMO-O-NITROTOLUENE ALPHA-BROMO-O-NITROTOLUENE ALPHA-BROMO-2-NITROTOLUENE O-NITROBENZYL BROMIDE NITROBENZYL-2 BROMIDE a-Bromo-2-nitrotoluene 2-Nitrobenzyl bromide, 98+% 2-Nitrobenzyl α-Bromo-2-nitrotoluene à-bromo-2-nitrotoluene 2-Benzyl bromide 1-Nitro-2-(bromomethyl)benzene 2-Nitrobenzyl bromide,97% 2-Nitrobenzyl bromid 1-(Bromomethyl)-2-nitrobenzene, alpha-Bromo-2-nitrotoluene 2-Nitrobenzyl broMide, 97% 5GR 2-Nitrobenayl broMide 2-Nitrobenzyl BroMide, 98.0%(GC) LIXI-011 α-Bromo-2-nitrotoluene alpha-Bromo-o-nitrotoluene 2-Nitrobenzyl bromide, 98%, for synthesis 2-NitrobenzylBromide> Rizatriptan EP Impurity3 1-(Bromomethyl)-2-nitrobenzene 3958-60-9 958-60-9 BENZYL HALIDE Nitrogen Compounds Organic Building Blocks Nitro Compounds DNA / RNA Synthesis Protecting Agents for Hydroxyl Group (DNA/RNA Synthesis) Building Blocks Biochemistry Nucleosides, Nucleotides & Related Reagents Protecting Agents for Hydroxyl and Amino Groups Protecting Agents, Phosphorylating Agents & Condensing Agents Aromatic Halides (substituted) ADVANCED INT.