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4-(4-Aminophenyl)butyric acid

4-(4-Aminophenyl)butyric acid structure

CAS No.: 15118-60-2

Chemical Name:: 4-(4-Aminophenyl)butyric acid

Synonyms: AKOS BB-8810;4-Amino-benzenebutanoic;p-Aminophenylbutyricacid;4-Aminophenylbutyric Acid;4-Aminobenzenebutanoic acid;4-(4-AMINOPHENYL)BUTYRIC ACID;4-(4-Aminophenyl)butanoicacid;Benzenebutanoic acid, 4-amino-;4-(4-azanylphenyl)butanoic acid;4-(4-AMinophenyl)butyric acid 95%

CBNumber:: CB9479760

Molecular Formula:: C10H13NO2

Molecular Weight:: 179.22

MDL Number:: MFCD00075052

MOL File:: 15118-60-2.mol

MSDS File:: SDS

Last updated:2026-05-28 05:50:24

Product description	Number	Pack Size	Price
4-(4-Aminophenyl)butyric acid 95%	335339	1g	$62.9
4-(4-Aminophenyl)butyric acid 95%	335339	5g	$227
4-(4-Aminophenyl)butyric acid Asreported	258512	500g	$2831
4-(4-Aminophenyl)butyric acid Asreported	258512	1kg	$4530
4-(4-Aminophenyl)butyric Acid	TRC-A622565-500MG	500mg	$84
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4-(4-Aminophenyl)butyric acid Properties

Melting point	121-124 °C (lit.) 121-133 °C
Boiling point	363.7±17.0 °C(Predicted)
Density	1.177±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	4.70±0.10(Predicted)
color	Light Beige to Light Brown
Major Application	peptide synthesis
InChI	InChI=1S/C10H13NO2/c11-9-6-4-8(5-7-9)2-1-3-10(12)13/h4-7H,1-3,11H2,(H,12,13)
InChIKey	RBHLFWNKEWLHBP-UHFFFAOYSA-N
SMILES	C1(CCCC(O)=O)=CC=C(N)C=C1
CAS DataBase Reference	15118-60-2(CAS DataBase Reference)
UNSPSC Code	12352106
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs	Respiratory system
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39
WGK Germany	3
HS Code	2922498590
Storage Class	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

4-(4-Aminophenyl)butyric acid price More Price(56)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	335339	4-(4-Aminophenyl)butyric acid 95%	15118-60-2	1g	$62.9	2026-04-30	Buy
Sigma-Aldrich	335339	4-(4-Aminophenyl)butyric acid 95%	15118-60-2	5g	$227	2026-04-30	Buy
Usbiological	258512	4-(4-Aminophenyl)butyric acid Asreported	15118-60-2	500g	$2831	2026-06-03	Buy
Usbiological	258512	4-(4-Aminophenyl)butyric acid Asreported	15118-60-2	1kg	$4530	2026-06-03	Buy
TRC	TRC-A622565-500MG	4-(4-Aminophenyl)butyric Acid	15118-60-2	500mg	$84	2026-06-03	Buy

Product number	Packaging	Price	Buy
335339	1g	$62.9	Buy
335339	5g	$227	Buy
258512	500g	$2831	Buy
258512	1kg	$4530	Buy
TRC-A622565-500MG	500mg	$84	Buy

4-(4-Aminophenyl)butyric acid Chemical Properties,Uses,Production

Description

4-(4-Aminophenyl)butyric acid (4-APB) is an important organic compound derived from butyric acid, which is used as a synthetic intermediate for pharmaceuticals or the synthesis of various compounds. It is also used in drug mechanism studies and is thought to be an agonist for certain G-protein coupled receptors and may also interact with other proteins in the signal transduction pathway. In addition, 4-(4-aminophenyl)butyric acid has been found to inhibit monoamine oxidase, which plays a role in neurotransmitter catabolism.

Uses

4-(4-Aminophenyl)butyric Acid is a degradation product of Chlorambucil (C325050); an alkylating agent that is used as an chemotherapy drug in the treatment of chronic lymphocytic leukemia. Chlorambucil is also used to treat non-Hodgkin''s lymphoma (NHL) and Hodgkin''s disease.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

5473-15-4

15118-60-2

The general procedure for the synthesis of 4-(4-aminophenyl)butyric acid from 4-(4-acetamidophenyl)-4-oxobutanoic acid was as follows: 89 g of 3-(4-acetamidophenyl)propionic acid, 88 g of potassium hydroxide, 65 ml of 85% hydrazine hydrate and 450 ml of diethylene glycol were mixed and heated and refluxed for 1.5 hours. Subsequently, the reaction temperature was raised to 150°C to remove excess hydrazine hydrate and the reaction was maintained at this temperature for 4 hours. Upon completion of the reaction, it was cooled to room temperature, 400 g of water was added, and the pH was adjusted to 6 with 6N hydrochloric acid, and then adjusted to 5-6 with glacial acetic acid. at this point, the target product precipitated as crystals, and after filtration, washing and drying, 44 g of white or near-white crystals were obtained in 95% yield.

References

[1] Patent: CN104447376, 2016, B. Location in patent: Paragraph 0032-0033; 0043-0044
[2] European Journal of Medicinal Chemistry, 2018, vol. 146, p. 588 - 598

4-(4-Aminophenyl)butyric acid Preparation Products And Raw materials

Raw materials

2-BENZOYLACETANILIDE Succinic anhydride Acetic acid Aluminium chloride hexahydrate Acetanilide

3-(4-ACETYLAMINOBENZOYL)PROPANOIC ACID Diethylene glycol Hydrazine hydrate Potassium hydroxide

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Preparation Products

METHYL 4-(4-AMINOPHENYL)BUTANOATE METHYL 4-(4-(BIS(2-HYDROXYETHYL)AMINO)PHENYL)BUTYRATE

4-(4-Aminophenyl)butyric acid Suppliers

Global( 158)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
DSHare Pharmaceutical Science Technology Co.Ltd.	+8613962878782	wei.zhu@dshare.com.cn	China	42	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
Chembon Pharmaceutical Co., Ltd.	+86-28-8425-2981		CHINA	722	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6366	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58

Supplier	Advantage
DSHare Pharmaceutical Science Technology Co.Ltd.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Chembon Pharmaceutical Co., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Xiamen AmoyChem Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58

View Lastest Price from 4-(4-Aminophenyl)butyric acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	4-(4-Aminophenyl)butyric acid 15118-60-2		1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2021-07-13	4-(4-Aminophenyl)butyric acid 15118-60-2	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	4-(4-Aminophenyl)butyric acid 15118-60-2	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

4-(4-Aminophenyl)butyric acid
15118-60-2
98%
Henan Aochuang Chemical Co.,Ltd.

4-(4-Aminophenyl)butyric acid
15118-60-2
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

4-(4-Aminophenyl)butyric acid
15118-60-2
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

4-(4-Aminophenyl)butyric acid Spectrum

4-(4-Aminophenyl)butyric acid(15118-60-2)¹HNMR 4-(4-Aminophenyl)butyric acid(15118-60-2)IR 4-(4-Aminophenyl)butyric acid(15118-60-2)Raman

15118-60-2(4-(4-Aminophenyl)butyric acid)Related Search:

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Chlorambucil BOC-(R)-3-AMINO-4-(4-NITRO-PHENYL)-BUTYRIC ACID N-Succinimidyl 4-(4-maleimidophenyl)butyrate 4-(4-Nitrophenyl)butyric acid 4-AMINO-D,L-BENZYLSUCCINIC ACID

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4-(4-Aminophenyl)butanoicacid 4-(4-Aminophenyl)butyric acid, ≥95.0% p-Aminophenylbutyricacid AKOS BB-8810 4-(4-AMINOPHENYL)BUTYRIC ACID 4-Aminophenylbutyric Acid 4-Aminobenzenebutanoic acid 4-Amino-benzenebutanoic 4-(4-azanylphenyl)butanoic acid 4-(4-Aminophenyl)butyric acid, 4-(3-Carboxyprop-1-yl)aniline 4-(4-AMinophenyl)butyric acid 95% Benzenebutanoic acid, 4-amino- 4-(4-Aminophenyl)butyric acid USP/EP/BP 15118-60-2 H2NC6H4CH23CO2H AMINE Others Peptide Synthesis Specialty Synthesis Unnatural Amino Acid Derivatives Others Peptide Synthesis Unnatural Amino Acid Derivatives