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Methyl 4-(4-aminophenyl)butanoate

Methyl 4-(4-aminophenyl)butanoate Structure
Methyl 4-(4-aminophenyl)butanoate structure
CAS No.
20637-09-6
Chemical Name:
Methyl 4-(4-aminophenyl)butanoate
Synonyms
Einecs 243-933-0;Methyl 4-aminobenzenebutanoate;Methyl 4-(4-Aminopheny)Butanoate;Methyl 4-(4-aminophenyl)butyrate;METHYL 4-(4-AMINOPHENYL)BUTYARTE;Methyl 4-(4-aminophenyl)butanoate;4-aminophenylbutyricacidmethylester;4-(4-Aminophenyl)butyricacidmethylester;4-Aminobenzenebutyric acid methyl ester;p-Aminobenzenebutanoic acid methyl ester
CBNumber:
CB3470831
Molecular Formula:
C11H15NO2
Molecular Weight:
193.24
MDL Number:
MFCD07366753
MOL File:
20637-09-6.mol
MSDS File:
SDS
Last updated:2026-09-12 18:52:04
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Methyl 4-(4-aminophenyl)butanoate Properties

Melting point 42 °C(Solv: ligroine (8032-32-4))
Boiling point 323.9±25.0 °C(Predicted)
Density 1.088±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 4.83±0.10(Predicted)
Appearance Brown to dark brown <42°C Solid,>42°C Liquid
InChI InChI=1S/C11H15NO2/c1-14-11(13)4-2-3-9-5-7-10(12)8-6-9/h5-8H,2-4,12H2,1H3
InChIKey CLKHQWJXESOLCJ-UHFFFAOYSA-N
SMILES C1(CCCC(OC)=O)=CC=C(N)C=C1
NIST Chemistry Reference 4-(4-Aminophenyl)butanoic acid methyl ester(20637-09-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2922498590

Methyl 4-(4-aminophenyl)butanoate price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR932646 Methyl 4-(4-aminophenyl)butanoate 95% 20637-09-6 1g $89 2026-06-04 Buy
Apolloscientific OR932646 Methyl 4-(4-aminophenyl)butanoate 95% 20637-09-6 5g $224 2026-06-04 Buy
Activate Scientific AS37785 Methyl 4-(4-aminophenyl)butanoate 97% 20637-09-6 1g $42 2026-06-04 Buy
Activate Scientific AS37785 Methyl 4-(4-aminophenyl)butanoate 97% 20637-09-6 5g $182 2026-06-04 Buy
Activate Scientific AS37785 Methyl 4-(4-aminophenyl)butanoate 97% 20637-09-6 25g $813 2026-06-04 Buy
Product number Packaging Price Buy
OR932646 1g $89 Buy
OR932646 5g $224 Buy
AS37785 1g $42 Buy
AS37785 5g $182 Buy
AS37785 25g $813 Buy

Methyl 4-(4-aminophenyl)butanoate Chemical Properties, Uses, Production

Chemical Properties

Needle-shaped crystals. Melting point 42°C.

Uses

Methyl 4-(4-Aminophenyl)butanoate is used in the synthesis of derivative of chlorambucil, a selective anti-cancer drug toward chondrosarcoma that would concentrate in this malignant cartilaginous tissue.

Synthesis

4-Nitrobenzenebutanoic acid methyl ester

20637-02-9

METHYL 4-(4-AMINOPHENYL)BUTANOATE

20637-09-6

b) Synthesis of methyl 4-(4-aminophenyl)butyrate Methyl 4-(4-nitrophenyl)butyrate (3.05 g, 13.67 mmol) and Pd/C catalyst (1.0 g, 10% Pd, activated carbon carrier, 1.09 mmol) were suspended in methanol (40 mL). The reaction mixture was stirred under hydrogen atmosphere (balloon pressure) for 1 hour. After completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad (washed with ethyl acetate). The filtrate was concentrated under reduced pressure to give 2.33 g of methyl 4-(4-aminophenyl)butyrate (brown solid, yield: 88%). The product did not require further purification and could be used directly in the next step of the reaction. 1H NMR (CDCl3, 250MHz) δppm: 6.96 (d, J=8.5Hz, 2H), 6.63 (d, J=8.2Hz, 2H), 3.66 (s, 3H), 2.55 (t, J=7.6Hz, 2H), 2.31 (t, J=7.7Hz, 2H), 1.90 (q, J=7.6Hz, 2H).

References

[1] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 17, p. 6463 - 6480
[2] Patent: WO2009/80722, 2009, A2. Location in patent: Page/Page column 52
[3] Journal of Pharmaceutical Sciences, 1988, vol. 77, # 2, p. 185 - 187
[4] Journal of the Chemical Society, 1953, p. 2386,2387
[5] Journal of Medicinal Chemistry, 1990, vol. 33, # 11, p. 3014 - 3019

Methyl 4-(4-aminophenyl)butanoate synthesis

67-56-1
15118-60-2
20637-09-6
Synthesis of Methyl 4-(4-aminophenyl)butanoate from Methanol and 4-(4-Aminophenyl)butyric acid

Methyl 4-(4-aminophenyl)butanoate Preparation Products And Raw materials

Raw materials

Hydrogen chloride methanol solution 4-(4-Aminophenyl)butyric acid Benzenebutanoic acid, 4-amino-γ-oxo-, methyl ester Benzenebutanoic acid, 4-nitro-γ-oxo-, methyl ester 4-(2-Nitro-phenyl)-butyric acid
4-(2-aminophenyl)butanoic acid methyl ester 4-Nitrobenzenebutanoic acid methyl ester 3-(4-Acetylaminobenzoyl)propanoic acid 4-(4-Nitrophenyl)butyric acid 4-Vinylanilin
Methanol Acetanilide (Trimethylsilyl)diazomethane Methyl thioglycolate 4-Phenylbutyric acid

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Preparation Products

Methyl 4-(4-aminophenyl)butanoate Suppliers

Global Suppliers ( 75)
Supplier Tel Email Country ProdList Advantage
Tianjin Derchemist Science & Technology Co., Ltd. 22-58627059 13920586291 zdcomcon@126.com China 4094 50
Chembon Pharmaceutical Co., Ltd. 028-84252981 18583719936 sales@chembon.com.cn China 854 64
Shanghai potentpharm CO.,Ltd (86) 21 51969655 China 486 22
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
Shanghai Raise Chemical Technology Co.,Ltd +86-021-50935922 China 7854 55
Shanghai Chainpharm Bio-medical Technology Co., Ltd. +86-021-61727342 13611721451 sales@chainpharm.com China 984 58
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794 sales@hcshhai.com China 9781 50
Shanghai XinKai Chemical Technology Co., Ltd. 021-58930698 15921516558 zhangyichao84@126.com China 984 55
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Zhengzhou Alfachem Co., Ltd. 0371-53765687 18937137882 3969243885@qq.com China 7734 55
Supplier Advantage
Tianjin Derchemist Science & Technology Co., Ltd. 50
Chembon Pharmaceutical Co., Ltd. 64
Shanghai potentpharm CO.,Ltd 22
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Shanghai Raise Chemical Technology Co.,Ltd 55
Shanghai Chainpharm Bio-medical Technology Co., Ltd. 58
Shanghai HuanChuan Industry Co.,Ltd. 50
Shanghai XinKai Chemical Technology Co., Ltd. 55
Cool Pharm, Ltd 58
Zhengzhou Alfachem Co., Ltd. 55

View Latest Price from Methyl 4-(4-aminophenyl)butanoate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
METHYL 4-(4-AMINOPHENYL)BUTANOATE pictures 2020-01-13 METHYL 4-(4-AMINOPHENYL)BUTANOATE
20637-09-6
 $6.68 1KG 97%-99% 1kg-1000kg Career Henan Chemical Co

Methyl 4-(4-aminophenyl)butanoate Spectrum

METHYL 4-(4-AMINOPHENYL)BUTANOATE(20637-09-6)1HNMR

20637-09-6 (Methyl 4-(4-aminophenyl)butanoate) Related Search:

4-(4-Nitro-phenyl)-3-oxo-butyric acid methyl ester Ethyl 4-[4-(N,N-dimethylamino)phenyl]-4-oxobutanoate Cyclopropanecarboxylic acid, 2-(4-nitrophenyl), ethyl ester (S)-N-alpha-(9-Fluorenylmethyloxycarbonyl)-2,4-dinitro-homo-phenylalanine methyl ester Methyl 4-(4-nitrophenyl)-2,4-dioxobutanoate
Ethyl 4-(4-aminophenyl)butanoate Methyl 4-(4-(bis(2-hydroxyethyl)amino)phenyl)butyrate Ethyl 4-(4-nitrophenyl)-4-oxobutyrate 4-(4-Nitro-phenyl)-3-oxo-butyric acid ethyl ester Methyl 4-(4-aminophenyl)butanoate
4-Phenylbutyric acid bestrabucil prednimustine Methylene dithiocyanate

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4-(4-Aminophenyl)butyricacidmethylester METHYL 4-(4-AMINOPHENYL)BUTYARTE 4-aminophenylbutyricacidmethylester Benzenebutanoic acid, 4-amino-, methyl ester Butyric acid, 4-(p-aminophenyl)-, methyl ester Methyl 4-(4-aminophenyl)butyrate Methyl 4-aminobenzenebutanoate 4-(4-Aminophenyl)butanoic acid methyl ester 4-Aminobenzenebutyric acid methyl ester p-Aminobenzenebutanoic acid methyl ester Methyl 4-(4-Aminopheny)Butanoate Einecs 243-933-0 Methyl 4-(4-aminophenyl)butanoate 20637-09-6