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N-METHYLISATIN

N-METHYLISATIN Structure
N-METHYLISATIN structure
CAS No.
2058-74-4
Chemical Name:
N-METHYLISATIN
Synonyms
1-methylindoline-2,3-dione;1-METHYLISATIN;1-METHYL-1H-INDOLE-2,3-DIONE;OL-57;187287;NSC 42449;AKOS BC-1698;N-Methylsatin;N-METHYLISATIN;1 METHYLISATINE
CBNumber:
CB9480285
Molecular Formula:
C9H7NO2
Molecular Weight:
161.16
MDL Number:
MFCD00005812
MOL File:
2058-74-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-04 16:00:12
Product description Number Pack Size Price
1-Methylisatin 97% 183075 1g $45.6
1-Methylisatin 97% 183075 10g $226
1-Methylisatin >98.0%(GC) M2706 1g $28
1-Methylisatin >98.0%(GC) M2706 5g $100
1-Methyl-1H-indole-2,3-dione FM125542 2g $150
More product size
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N-METHYLISATIN Properties

Melting point 130-133 °C (lit.)
Boiling point 287.44°C (rough estimate)
Density 1.314
refractive index 1.5050 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka -2.41±0.20(Predicted)
form Crystalline Powder
color Orange to brownish
Water Solubility Insoluble in water.
λmax 427nm(CH2Cl2)(lit.)
BRN 128280
InChI InChI=1S/C9H7NO2/c1-10-7-5-3-2-4-6(7)8(11)9(10)12/h2-5H,1H3
InChIKey VCYBVWFTGAZHGH-UHFFFAOYSA-N
SMILES N1(C)C2=C(C=CC=C2)C(=O)C1=O
CAS DataBase Reference 2058-74-4(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII CNV9DH4SXQ
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Skull and Crossbones (GHS06)
GHS05,GHS06
Signal word  Danger
Hazard statements  H301-H315-H318-H335
Precautionary statements  P280-P301+P310+P330-P302+P352-P305+P351+P338+P310
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Codes  T
Risk Statements  25-37/38-41
Safety Statements  26-39-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  NL7939000
HazardClass  IRRITANT
HS Code  29337900
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
Toxicity mouse,LD50,intraperitoneal,685mg/kg (685mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION,Pharmaceutical Chemistry Journal Vol. 15, Pg. 858, 1981.
Limited Quantities 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
2 0

N-METHYLISATIN price More Price(86)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 183075 1-Methylisatin 97% 2058-74-4 1g $45.6 2026-04-30 Buy
Sigma-Aldrich 183075 1-Methylisatin 97% 2058-74-4 10g $226 2026-04-30 Buy
TCI Chemical M2706 1-Methylisatin >98.0%(GC) 2058-74-4 1g $28 2026-04-30 Buy
TCI Chemical M2706 1-Methylisatin >98.0%(GC) 2058-74-4 5g $100 2026-04-30 Buy
Biosynth FM125542 1-Methyl-1H-indole-2,3-dione 2058-74-4 2g $150 2026-06-04 Buy
Product number Packaging Price Buy
183075 1g $45.6 Buy
183075 10g $226 Buy
M2706 1g $28 Buy
M2706 5g $100 Buy
FM125542 2g $150 Buy

N-METHYLISATIN Chemical Properties,Uses,Production

Chemical Properties

ORANGE TO BROWNISH CRYSTALLINE POWDER

Uses

1-Methylisatin is used as a reactant for stereoselective preparation of spirobicyclic and bis-spirotricyclic pyrazolidinones, for regioselective preparation of spirocyclic oxindole-butenolides, for synthesis of spiro-oxindoles, for preparation of unsymmetrical oxindoles, for stereoselective preparation of hydroxyloxindoles via Morita-Baylis-Hillman reaction, for preparation of pyridinecarboxylic acid [(oxo)indolylidene)hydrazide derivatives (Schiff base hydrazides) as antibacterial agents.

Uses

  • Reactant for stereoselective preparation of spirobicyclic and bis-spirotricyclic pyrazolidinones
  • Reactant for regioselective preparation of spirocyclic oxindole-butenolides
  • Reactant for synthesis of spiro-oxindoles
  • Reactant for preparation of unsymmetrical oxindoles
  • Reactant for stereoselective preparation of hydroxyloxindoles via Morita-Baylis-Hillman reaction
  • Reactant for preparation of pyridinecarboxylic acid [(oxo)indolylidene)hydrazide derivatives (Schiff base hydrazides) as antibacterial agents

Synthesis Reference(s)

Journal of Medicinal Chemistry, 47, p. 2089, 2004 DOI: 10.1021/jm030483s

General Description

The interaction between 1-methylisatin and human adult haemoglobin was studied using the circular dichroism (CD) spectroscopic, anisotropy and FTIR investigations.

IC 50

hiCE: 38.2 μM (Ki); hCE1: 5.38 μM (Ki)

N-METHYLISATIN synthesis

74-83-9
91-56-5
2058-74-4
Synthesis of N-METHYLISATIN from Methyl bromide and Isatin

N-METHYLISATIN Preparation Products And Raw materials

Raw materials

2-Butynamide, N-methyl-N-phenyl- 2-Propynamide, N-methyl-N-phenyl- 2-Propenamide,N-methyl-N,3-diphenyl- Acetamide, N-methyl-2-(methylphenylamino)- 2-Propynamide, N-methyl-N,3-diphenyl-
1-Methylindoline 4-Acetylbenzoic acid 1-METHYL-2-INDOLINONE Ethanone, 1-[2-(methylamino)phenyl]- (9CI) Isatin
1-benzyl-5-iodoindoline-2,3-dione 5-iodo-1-methylindoline-2,3-dione

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Preparation Products

2-Thiophenecarboxylic acid 5-METHYL-1,2,4-TRIAZINO[5,6-B]INDOLE-3-THIOL 1-METHYL-1H-INDOLE-2,3-DIONE 3-[N-(4-CHLOROPHENYL)HYDRAZONE] (7Z)-3-(4-fluorophenyl)-7-(1-methyl-2-oxoindol-3-ylidene)-2,4-dihydro-[1,3]thiazolo[3,2-a][1,3,5]triazin-6-one

N-METHYLISATIN Suppliers

Global( 186)Suppliers
Supplier Tel Email Country ProdList Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-15225627621 +86-13213167925 jiuyitime@fdachem.com China 16511 58
Hefei Lbao Physical & Chemical Science Co.,Ltd 		+15184799099 lbaochemicals@gmail.com China 670 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 17389186172 1077@dideu.com China 3796 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Blocksynth Pharmaceutical Technology Co.,Ltd 		0086-19817745290; +8619817745290 bd@blocksynth.com China 5973 58
Finetech Industry Limited 		+86-27-8746-5837 +8619945049750 info@finetechnology-ind.com China 9539 58
Supplier Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Hefei Lbao Physical & Chemical Science Co.,Ltd 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Blocksynth Pharmaceutical Technology Co.,Ltd 		58
Finetech Industry Limited 		58

View Lastest Price from N-METHYLISATIN manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-methylisatin pictures 2026-07-02 1-methylisatin
2058-74-4
 $2.20-8.80 1kg 99%min 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
1-Methylisatin pictures 2026-05-18 1-Methylisatin
2058-74-4
 1kg 98% Hefei Lbao Physical & Chemical Science Co.,Ltd
1-Methylisatin 97% pictures 2021-07-02 1-Methylisatin 97%
2058-74-4
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
  • 1-methylisatin pictures
  • 1-methylisatin
    2058-74-4
  • $2.20-8.80
  • 99%min
  • ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
  • 1-Methylisatin pictures
  • 1-Methylisatin
    2058-74-4
  • $0.00
  • 98%
  • Hefei Lbao Physical & Chemical Science Co.,Ltd
  • 1-Methylisatin 97% pictures
  • 1-Methylisatin 97%
    2058-74-4
  • $10.00-15.00
  • 99%+ HPLC
  • Zhuozhou Wenxi import and Export Co., Ltd

N-METHYLISATIN Spectrum

N-METHYLISATIN(2058-74-4)1HNMRN-METHYLISATIN(2058-74-4)IR1N-METHYLISATIN(2058-74-4)IR2N-METHYLISATIN(2058-74-4)Raman

2058-74-4(N-METHYLISATIN)Related Search:

3-(1-methyl-1H-indole-3-carbonyl)hexanedioic acid (3R)-2,3-Dihydro-3-(2-propyn-1-ylaMino)-1H-inden-1-one 1-Methyl-1H-indole-3-carboxylic acid 1-Methylindole Ramosetron hydrochloride
Rasagiline Impurity 5 Mesylate 5-(1-methyl-1H-indole-3-carbonyl)-1H-benzo[d]imidazol-2(3H)-one ramosetron 4,5,6,7-Tetrahydro-1H-benzoiMidazole-5-carboxylic acid hydrochloride Rasagiline Impurity 3
3a,7a-dihydroxy-5-(1-methyl-1H-indole-3-carbonyl)-hexahydro-1H-benzo[d]imidazol-2(3H)-one Ramosetron Impurity 13 N-[4,5,6,7-Tetrahydrobenzimidazole-5-yl)carbonyl] pyrrolidine sulfate 1-PHENYLISATIN 1-(Hydroxymethyl)indoline-2,3-dione
N-METHYLISATIN 1,5-DIMETHYLINDOLINE-2,3-DIONE 5-CHLORO-7-METHYLISATIN

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187287 1-Methyl-2,3-dihydro-1H-indole-2,3-dione OL-57 N-Methylindol-2,3-dione 1-Methylisatin,98% N-Methylindoline-2,3-dione 1-Methyl-1H-indole-2,3-dione, 1-Methylindolin-2,3-dione 1-Methylisatin 97+% 1-Methylisatin 97% NSC 42449 1H-Indole-2,3-dione, 1-methyl- (9CI) 1H-Indole-2,3-dione, 1-Methyl- Indole-2,3-dione, 1-methyl- Ramosetron Impurity 1 1-methyl-1h-indole-3-dione 1-methyl-indole-2,3-dione 1-methyl-indole-3-dione 1 METHYLISATINE N-METHYLISATIN TIMTEC-BB SBB006835 1-methyl-2,3-dihydroindole-2,3-dione Methylisatintech N-Methylsatin N-Methylisatin, tech. N-Methylisatin 98% AKOS BBS-00000999 AKOS BC-1698 1-Methylisatin, 97%, for synthesis 1-Methylisatin > 1-Methylindoline-2,3-dione (Ramosetron Impurity) 1-methylindoline-2,3-dione 1-METHYL-1H-INDOLE-2,3-DIONE 1-METHYLISATIN 2058-74-4 Indoles Heterocyclic Building Blocks Building Blocks Heterocycles Building Blocks Heterocyclic Building Blocks Indoles pharmacetical