Amiloride hydrochloride dihydrate
- CAS No.
- 17440-83-4
- Chemical Name:
- Amiloride hydrochloride dihydrate
- Synonyms
- AMilorida;AMILORIDE HCL DIHYDRATE;Modamide;Amiloride hydrochlorid;AMiloride hydrocholride;AMILORIDEHYDROCHLORIDE,USP;MK-870 hydrochloride dihydrate;AMILORIDE HYDROCHLORIDE (500 MG);Miloride hydrochloride dihydrate;Amiloride HCl dihydrate (MK 870)
- CBNumber:
- CB9501409
- Molecular Formula:
- C6H8ClN7O.HCl.2H2O
- Molecular Weight:
- 302.12
- MDL Number:
- MFCD00211292
- MOL File:
- 17440-83-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >240℃ |
|---|---|
| RTECS | UQ2275500 |
| storage temp. | Store at -20°C |
| solubility | Slightly soluble in water and in anhydrous ethanol. |
| pka | 8.7(at 25℃) |
| form | Solid |
| color | Off-white to yellow |
| Water Solubility | Soluble in water at 50mg/ml |
| Major Application | pharmaceutical |
| InChI | InChI=1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2 |
| InChIKey | LTKVFMLMEYCWMK-UHFFFAOYSA-N |
| SMILES | C1(C(NC(N)=N)=O)=NC(Cl)=C(N)N=C1N.[H]Cl.[H]O[H].[H]O[H] |
| FDA UNII | FZJ37245UC |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310a-P321-P405-P501a |
| WGK Germany | 3 |
| HazardClass | 6.1 |
| HS Code | 2933995300 |
| Storage Class | 11 - Combustible Solids |
Amiloride hydrochloride dihydrate price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR1839 | Amiloride hydrochloride | 17440-83-4 | 1g | $248 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1019701 | Amiloride hydrochloride | 17440-83-4 | 500mg | $455 | 2026-04-30 | Buy |
| TRC | TRC-A684560-500MG | Amiloride Monohydrochloride Dihydrate | 17440-83-4 | 500mg | $84 | 2026-06-03 | Buy |
| TRC | TRC-A684560-1G | Amiloride Monohydrochloride Dihydrate | 17440-83-4 | 1g | $103 | 2026-06-03 | Buy |
| TRC | TRC-A684560-100MG | Amiloride Monohydrochloride Dihydrate | 17440-83-4 | 100mg | $76 | 2026-06-03 | Buy |
Amiloride hydrochloride dihydrate Chemical Properties, Uses, Production
Chemical Properties
Pale yellow or greenish-yellow powder.
Uses
Amiloride hydrochloride dihydrate is used as a calcium channel and sodium channel protein inhibitor. It reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 M. Amiloride HCl is an inhibitor of Sodium/Potassium-ATPase Protein. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.
Uses
Diuretic;Antialdosteron
Uses
An epithelial sodium channel blocker
Definition
ChEBI: A hydrate that is the dihydrate of amiloride hydrochloride.
brand name
Midamor (Merck).
in vivo
Amiloride hydrochloride dihydrate is a potent epithelial sodium channels (ENaCs) blocker. Amiloride is highly concentrated in the plasma 15 to 30 minutes following the injections. 2 mg/kg dose of Amiloride hydrochloride dihydrate has no effect on blood pressure, heart rate, mesenteric vascular resistance, or hindquarters vascular resistance as compare to the baseline measurements (n=7). Over a 2 hour period, Amiloride hydrochloride dihydrate elicits negligible responses in arterial pressure (-1±1 mmHg) and heart rate (-10±6 bpm/min) as compare to baseline levels. Results show an Amiloride hydrochloride dihydrate dose-related response pattern for the c-Fos activation in the area postrema (AP). Even at the lowest dose of Amiloride hydrochloride dihydrate (0.1 mg/kg), the number of c-Fos labeled neurons in the AP is statistically different from the control rats at a p<0.01 level[1].
Amiloride hydrochloride dihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Lingyuan Bebiansen Biological Technology Co., Ltd | 18642120371 | 2837458851@qq.com | China | 7961 | 58 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1490 | 55 | |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| Hubei Jusheng Technology Co.,Ltd | 027-59599241 18871490274 | 1400878000@qq.com | China | 9506 | 58 |
| Chizhou Kailong Import and Export Trade Co., Ltd. | xg01_gj@163.com | China | 9413 | 50 | |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
View Latest Price from Amiloride hydrochloride dihydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | Amiloride hydrochloride dihydrate
17440-83-4
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2019-07-10 | Amiloride hydrochloride dihydrate
17440-83-4
|
$1.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- Amiloride hydrochloride dihydrate
17440-83-4
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Amiloride hydrochloride dihydrate
17440-83-4
- $1.00
- 99%
- Career Henan Chemical Co
