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Cefpodoxime

Cefpodoxime Structure
Cefpodoxime structure
CAS No.
80210-62-4
Chemical Name:
Cefpodoxime
Synonyms
CPDX;Cefpodoxima;Cefpodoxime;Cefpodoximum;Unii-7R4F94tvgy;Cefpodoxime sulfate;Cefpodoximum [latin];Cefpodoxime (R 3763);Cefpodoxima [spanish];Cefpodoxime USP/EP/BP
CBNumber:
CB9511604
Molecular Formula:
C15H17N5O6S2
Molecular Weight:
427.46
MDL Number:
MFCD00864906
MOL File:
80210-62-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 06:15:38
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Cefpodoxime Properties

Melting point 200-202°C
Density 1.78±0.1 g/cm3(Predicted)
RTECS XI0367365
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Soluble in DMSO
pka 2.77±0.50(Predicted)
form Solid
color White to off-white
Sensitive Light Sensitive
BRN 6021381
Stability Hygroscopic
Major Application forensics and toxicology
veterinary
InChIKey WYUSVOMTXWRGEK-HBWVYFAYSA-N
SMILES O=C(/C(C1=CSC(N)=N1)=N\OC)N[C@H](C2=O)[C@]3([H])N2C(C(O)=O)=C(COC)CS3
FDA UNII 7R4F94TVGY
ATC code J01DD13
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P280-P342+P311
Hazard Codes  Xn
Risk Statements  42/43
Safety Statements  22-36/37-45
WGK Germany  3
Storage Class 11 - Combustible Solids
Hazard Classifications Resp. Sens. 1
Skin Sens. 1

Cefpodoxime price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 32344 Cefpodoxime VETRANAL 80210-62-4 25mg $86.6 2026-04-30 Buy
Cayman Chemical 16075 Cefpodoxime ≥95% 80210-62-4 10mg $36 2026-04-30 Buy
Cayman Chemical 16075 Cefpodoxime ≥95% 80210-62-4 25mg $73 2026-04-30 Buy
Cayman Chemical 16075 Cefpodoxime ≥95% 80210-62-4 50mg $134 2026-04-30 Buy
Cayman Chemical 16075 Cefpodoxime ≥95% 80210-62-4 100mg $234 2026-04-30 Buy
Product number Packaging Price Buy
32344 25mg $86.6 Buy
16075 10mg $36 Buy
16075 25mg $73 Buy
16075 50mg $134 Buy
16075 100mg $234 Buy

Cefpodoxime Chemical Properties, Uses, Production

Chemical Properties

Off-White Solid

Uses

A metabolite of Cefpodoxime Proxetil. An antibacterial.

Uses

A metabolite of Cefpodoxime Proxetil (C243860). An antibacterial.

Uses

Cefpodoxime Proxetil metabolite antibiotic

Definition

ChEBI: A third-generation cephalosporin antibiotic with methoxymethyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamino substituents at positions 3 and 7, respectively, of the cephem skeleton. Given by mouth as its proxetil ester prodrug, it is used to treat acute otitis media, pharyngitis, and sinusitis.

brand name

Vantin (Pharmacia & Upjohn).

Antimicrobial activity

It is stable to a wide range of plasmid-mediated β-lactamases. It induces the chromosomal β-lactamases of Ps. aeruginosa, Enterobacter spp., S. marcescens and Citrobacter spp., but is a less potent inducer than cefoxitin.

Biological Activity

cefpodoxime, as known as r 3763, is a metabolite of cefpodoxime proxetil. it is demonstrated that cefpodoxime, as an oral third generation cephalosporin antibiotic, is active against most gram-positive and gram-negative bacteria.cefpodoxime suppresses bacterial septum and cell wall synthesis by binding to penicillin-binding proteins (pbps) located in the bacterial cytoplasmic membrane.

Pharmacokinetics

Oral absorption: c. 50%
Cmax 200 mg oral: 2.1 mg/L after 3 h
Plasma half-life: c. 2.2 h
Volume of distribution: c. 35 L
Plasma protein binding: 20–30%
Absorption and distribution
The ester is rapidly hydrolyzed to the parent compound in the small intestine. Bioavailability increases to 65% if taken with food, but antacids and H2-receptor antagonists reduce absorption. Unabsorbed drug is hydrolyzed and excreted in the feces.
It is well distributed and penetrates well into tissues (including lung tissue) and inflammatory exudate to achieve concentrations inhibitory to common pathogens.
Metabolism and excretion
The hydrolyzed prodrug is not subject to further metabolism. About 80% of the absorbed compound (30–40% of the original dose) appears in the urine over 24 h. Excretion is by glomerular filtration and tubular secretion; probenecid delays secretion and increases the peak plasma concentration.
Metabolism and excretion
The hydrolyzed prodrug is not subject to further metabolism. About 80% of the absorbed compound (30–40% of the original dose) appears in the urine over 24 h. Excretion is by glomerular filtration and tubular secretion; probenecid delays secretion and increases the peak plasma concentration.

Clinical Use

Cefpodoxime has been used principally for the treatment of upper and lower respiratory tract infections in children and adults.

Side effects

The drug is well tolerated, but gastrointestinal disturbance with diarrhea is common. Pseudomembranous colitis has been reported occasionally. Other side effects are those common to cephalosporins.

in vitro

cefpodoxime showed antibacterial activities against obligatory anaerobes and salmonella spp., shigella spp. and neisseria meningitides. the activity of cefpodoxime was less active than r95867, an active form of cs-834, against gram-negative bacteria [1]. cefpodoxime was quite stable to hydrolysis by β-lactamases produced from b. cereus and e. coli hb101/pbr322 [2].

in vivo

male ddy mice were administered orally in a volume of 0.2 ml of 0.5% carboxymethyl cellulose sodium salt. after 7 days, it was shown that cefpodoxime had good efficacy against streptococcus spp. and k. pneumoniae infection in mice [1].

References

[1]. sakagawa, e., otsuki, m., oh, t., & nishino, t. in-vitro and in-vivo antibacterial activities of cs-834, a new oral carbapenem. journal of antimicrobial chemotherapy, 1998; 42: 426-437.
[2]. fukuoka, t., ohya, s., utsui, y., domon, h., takenouchi, t., koga, t., … kuwahara, s. in vitro and in vivo antibacterial activities of cs-834, a novel oral carbapenem. antimicrobial agents and chemotherapy, 1997; 41(12): 2652–2663.

Cefpodoxime Preparation Products And Raw materials

Raw materials

Preparation Products

Cefpodoxime proxetil

Cefpodoxime Suppliers

Global Suppliers ( 155)
Supplier Tel Email Country ProdList Advantage
Lanzhou Dawnrays Pharmaceutical Co Ltd 0931-0931-4910898 19913936884 sales@dawnrays.com China 39 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
LGM Pharma 1-(800)-881-8210 inquiries@lgmpharma.com United States 2110 70
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32273 50
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-4000505016 13380397412 3001272453@qq.com China 5000 50
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12323 58
Clearsynth Labs Limited +91-22-26355700 info@clearsynth.com India 9656 58
Nanjing Sunlida Biological Technology Co., Ltd. 025-57798810 18652991625 sales@sunlidabio.com China 3223 55
Cato Research Chemicals Inc. 020-81960175 min.he@cato-chem.com China 1949 55
Supplier Advantage
Lanzhou Dawnrays Pharmaceutical Co Ltd 58
J & K SCIENTIFIC LTD. 76
LGM Pharma 70
Chemsky（shanghai）International Co.,Ltd. 50
Dalian Meilun Biotech Co., Ltd. 58
S.Z. PhyStandard Bio-Tech. Co., Ltd. 50
Beijing HuaMeiHuLiBiological Chemical 58
Clearsynth Labs Limited 58
Nanjing Sunlida Biological Technology Co., Ltd. 55
Cato Research Chemicals Inc. 55

Related articles

View Latest Price from Cefpodoxime manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cefpodoxime pictures 2026-08-25 Cefpodoxime
80210-62-4
 1kg 0.99 1000kg Shaanxi Xianhe Biotech Co., Ltd
Cefpodoxime pictures 2026-05-28 Cefpodoxime
80210-62-4
 $80.70 10kg 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
Cefpodoxime pictures 2020-05-25 Cefpodoxime
80210-62-4
 1KG 99.0%+ 300 MT Shaanxi Dideu Medichem Co. Ltd
  • Cefpodoxime pictures
  • Cefpodoxime
    80210-62-4
  • $0.00
  • 0.99
  • Shaanxi Xianhe Biotech Co., Ltd
  • Cefpodoxime pictures
  • Cefpodoxime
    80210-62-4
  • $80.70
  • 99%
  • Hebei Chuanghai Biotechnology Co,.LTD
  • Cefpodoxime pictures
  • Cefpodoxime
    80210-62-4
  • 99.0%+
  • Shaanxi Dideu Medichem Co. Ltd

Cefpodoxime Spectrum

Cefpodoxime(80210-62-4)1HNMR

80210-62-4 (Cefpodoxime) Related Search:

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Cefpodoxime Proxetil impurity 1/Cefpodoxime Proxetil EP Impurity A/ Cefpodoxime Acid/(6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Cefpodoxime Proxetil EP Impurity A (Cefpodoxime Acid) Cefpodoxime proxetil Impurity A:( (6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid(Cefpodoxime Acid) (6R,7R)-7α-[[(2-Aminothiazol-4-yl)[(Z)-methoxyimino]acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetyl]amino]-3-methoxymethylcepham-3-ene-4-carboxylic acid CPDX 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(methoxymethyl)-8-oxo-, (6R-(6alpha,7beta(Z)))- Cefpodoxima Cefpodoxima [spanish] Cefpodoximum Cefpodoximum [latin] Unii-7R4F94tvgy (6R,7R)-7-{2-(2-Amino-4-thiazolyl)-2-[(Z)-methoxyimino]acetamido}-3-(methoxymethyl)-3-cephem-4-carboxylate Cefpodoxime sulfate (6R-(6alpha,7beta(Z)))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Cefpodoxime (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Cefpodoxime Proxetil Impurity 1(Cefpodoxime Proxetil EP Impurity A) (6R,7R)-7α-[[(2-Amino-4-thiazolyl)[(Z)-methoxyimino]acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid Cefpodoxime-D3Acid(98%,99Atom%D) Cefpodoxime Proxetil EP Impurity A 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-, (6R,7R)- Cefpodoxime Proxetil Impurity 1（EP Impurity A） Cefpodoxime USP/EP/BP Cefpodoxime D3 AcidQ: What is Cefpodoxime D3 Acid Q: What is the CAS Number of Cefpodoxime D3 Acid Q: What is the storage condition of Cefpodoxime D3 Acid Q: What are the applications of Cefpodoxime D3 Acid CefpodoximeAcidQ: What is CefpodoximeAcid Q: What is the CAS Number of CefpodoximeAcid Q: What is the storage condition of CefpodoximeAcid Q: What are the applications of CefpodoximeAcid Cefpodoxime tablet 200mg Cefpodoxime,Bacterial,gram-negative bacteria,R-3763,Cefpodoxime (free acid),Cefpodoxime acid,Antibiotic,R 3763,Inhibitor,R3763,gram-positive bacteria,inhibit CEFPODOXIME COMPACTED Cefpodoxime (free acid), 10 mM in DMSO Cefpodoxime (R 3763) Cefpodoxime acid, Antibiotic for Culture Media Use Only Cefpodoxime 100 μg/mL in Acetonitrile Cefpodoxime Proxetil Impurity A(CP) (6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Cefpodoxime Proxetil Impurity) Cefpodoxime phosphate EP impurity A (+)-(6R,7R)-7-[2-(2-Aminothiazol-4-yl)-2(Z)-methoxyiminoacetamido]-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 80210-62-4 Various Metabolites and Impurities Heterocycles Sulfur & Selenium Compounds Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals