1-(2-Methoxyphenyl)piperazine
- CAS No.
- 35386-24-4
- Chemical Name:
- 1-(2-Methoxyphenyl)piperazine
- Synonyms
- 2-MPP;D 15157;AKOS BBS-00003584;Uradil impurity 18;Urapidil Impurity 6;TIMTEC-BB SBB003620;RARECHEM AH CK 0126;2-Piperazinoanisole;Urapidil Impurity C;LABOTEST-BB LT00233095
- CBNumber:
- CB9669765
- Molecular Formula:
- C11H16N2O
- Molecular Weight:
- 192.26
- MDL Number:
- MFCD00005958
- MOL File:
- 35386-24-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 1-(2-Methoxyphenyl)piperazine 98% | M22601 | 5g | $48.4 |
| 1-(2-Methoxyphenyl)piperazine 98% | M22601 | 25g | $114 |
| 1-(2-Methoxyphenyl)piperazine >98.0%(GC)(T) | M0883 | 5g | $33 |
| 1-(2-Methoxyphenyl)piperazine >98.0%(GC)(T) | M0883 | 25g | $84 |
| 1-(2-Methoxyphenyl)piperazine | TRC-M266220-5G | 5g | $96 |
| More product size | |||
| Melting point | 35-40 °C (lit.) |
|---|---|
| Boiling point | 130-133 °C/0.1 mmHg (lit.) |
| Density | 1.095 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Liquid After Melting |
| pka | 8.98±0.10(Predicted) |
| color | Clear colorless to yellow |
| Water Solubility | Soluble in chloroform, ethyl acetate, and methanol. Insoluble in water |
| Sensitive | Air Sensitive |
| BRN | 167888 |
| InChI | InChI=1S/C11H16N2O/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3 |
| InChIKey | VNZLQLYBRIOLFZ-UHFFFAOYSA-N |
| SMILES | N1(C2=CC=CC=C2OC)CCNCC1 |
| LogP | 1.67 |
| CAS DataBase Reference | 35386-24-4(CAS DataBase Reference) |
| FDA UNII | 81NJO1330A |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | C,Xi | |||||||||
| Risk Statements | 34-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-45-28A-36 | |||||||||
| RIDADR | UN 3263 8/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Eye Dam. 1 Skin Corr. 1B |
|||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
1-(2-Methoxyphenyl)piperazine price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M22601 | 1-(2-Methoxyphenyl)piperazine 98% | 35386-24-4 | 5g | $48.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | M22601 | 1-(2-Methoxyphenyl)piperazine 98% | 35386-24-4 | 25g | $114 | 2026-04-30 | Buy |
| TCI Chemical | M0883 | 1-(2-Methoxyphenyl)piperazine >98.0%(GC)(T) | 35386-24-4 | 5g | $33 | 2026-04-30 | Buy |
| TCI Chemical | M0883 | 1-(2-Methoxyphenyl)piperazine >98.0%(GC)(T) | 35386-24-4 | 25g | $84 | 2026-04-30 | Buy |
| TRC | TRC-M266220-5G | 1-(2-Methoxyphenyl)piperazine | 35386-24-4 | 5g | $96 | 2026-06-03 | Buy |
1-(2-Methoxyphenyl)piperazine Chemical Properties,Uses,Production
Chemical Properties
clear colorless to yellow liquid after melting
Uses
A piperazine derivative and a selective antagonist at D3 receptors that influences the expression of cocaine-induced conditioned place preference (CPP).
Uses
It is used as pharmaceutical intermediate. N-alkylated 1-(2-methyoxyphenyl)piperazines markedly improved affinity and selectivity of the dopamine D3 receptor which is recognized as a potential therapeutic target for the treatment of various neurological and psychiatric disorders.
Uses
1-(2-Methoxyphenyl)piperazine can be used:
- To functionalize pyrazolylvinyl ketones via Aza-Michael addition reaction.
- To prepare cyclic amine substituted Trger′s base derivatives.
- To prepare functionalized bis(mercaptoimidazolyl)borates by reacting with the activated ester, [(1-methyl-2-mercaptoimidazol-5-yl)carbonyl]succinimide.
Definition
ChEBI: 1-(2-methoxyphenyl)piperazine is a member of piperazines.
Synthesis
Preparation of 1-(2-methoxyphenyl)piperazine hydrobromide:
Place 189g of diethanolamine and 2000ml of 40% hydrobromic acid in a three-mouth flask equipped with stirring, reflux condenser and a thermometer, and heat to reflux for 12h. After the reaction, the condenser was converted into a Vigro fractionation column to fractionate until there was no distillate. The first fraction was discarded, and the continuing fraction was recovered for reuse. Cooling, add 670ml ethanol, remove the fractionation column, install the condenser, slowly add 243g o-aminoanisole, heated reflux 10h, add 90g anhydrous sodium carbonate, and then continue to reflux for 10h, pour into a beaker while still hot, cooling, filter out the crystals, and then recrystallize from ethanol to obtain a white scaly crystals, yield of 155g, m.p. 232.4 ~ 234.6 , yield of 31.6%.
Preparation of 1-(2-methoxyphenyl) piperazine:
Suspend 155g of 1-( 2-methoxyphenyl) piperazine hydrobromide in 150ml of water, add 40% of sodium hydroxide solution, neutralize to strong alkaline, leave to stand, extract the oil layer, remove water by pressure-reduced distillation and collect the fraction at 129134 0.1mmHg, yield 103.2g, content 97.5%98.2%. Content: 97.5%-98.2%. It is colorless oily liquid with 95% yield. The total yield was calculated as 30% with diethanolamine.
1-(2-Methoxyphenyl)piperazine Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9322 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 738 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14320 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10817 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 |
View Lastest Price from 1-(2-Methoxyphenyl)piperazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 1-(2-Methoxyphenyl)piperazine
35386-24-4
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-12-25 | 1-(2-Methoxyphenyl)piperazine
35386-24-4
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2025-04-04 | AochuangChem-1-(2-Methoxyphenyl)piperazine
35386-24-4
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 1-(2-Methoxyphenyl)piperazine
35386-24-4
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 1-(2-Methoxyphenyl)piperazine
35386-24-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- AochuangChem-1-(2-Methoxyphenyl)piperazine
35386-24-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
1-(2-Methoxyphenyl)piperazine Spectrum
35386-24-4(1-(2-Methoxyphenyl)piperazine)Related Search:
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