6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil
![6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil Structure](CAS/GIF/34661-75-1.gif)
- CAS No.
- 34661-75-1
- Chemical Name:
- 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil
- Synonyms
- URAPIDIL;ebrantil;Urapidil Urapidil;BKU;b-66256;Eupressyl;Mediatensyl;UrapidilC20H29N503;Urapidil, 10 mM in DMSO;4-dichlorophenoxyacetate
- CBNumber:
- CB8305730
- Molecular Formula:
- C20H29N5O3
- Molecular Weight:
- 387.48
- MDL Number:
- MFCD00133908
- MOL File:
- 34661-75-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 156-158° |
|---|---|
| Boiling point | 513.42°C (rough estimate) |
| Density | 1.2058 (rough estimate) |
| refractive index | 1.7600 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO: 25 mg/mL (64.52 mM); Water: < 0.1 mg/mL (insoluble) |
| form | powder to crystal |
| pka | 7.10(at 25℃) |
| color | White to Light yellow to Light orange |
| λmax | 268nm(MeOH)(lit.) |
| Merck | 14,9865 |
| InChI | InChI=1S/C20H29N5O3/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3/h4-5,7-8,15,21H,6,9-14H2,1-3H3 |
| InChIKey | ICMGLRUYEQNHPF-UHFFFAOYSA-N |
| SMILES | C1(=O)N(C)C(NCCCN2CCN(C3=CC=CC=C3OC)CC2)=CC(=O)N1C |
| CAS DataBase Reference | 34661-75-1(CAS DataBase Reference) |
| FDA UNII | A78GF17HJS |
| ATC code | C02CA06 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26 |
| RTECS | YQ9862000 |
| HS Code | 2933.59.8000 |
| Toxicity | LD50 in male mice, rats (mg/kg): 750, 550 orally; 260, 145 i.v. (Koenig) |
6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | U0085 | Urapidil >98.0%(HPLC)(T) | 34661-75-1 | 1g | $26 | 2026-04-30 | Buy |
| TCI Chemical | U0085 | Urapidil >98.0%(HPLC)(T) | 34661-75-1 | 5g | $136 | 2023-06-20 | Buy |
| Usbiological | 291851 | Urapidil Asreported | 34661-75-1 | 50mg | $352 | 2026-06-03 | Buy |
| Usbiological | 291851 | Urapidil Asreported | 34661-75-1 | 100mg | $496 | 2026-06-03 | Buy |
| Usbiological | 291851 | Urapidil Asreported | 34661-75-1 | 250mg | $658 | 2026-06-03 | Buy |
6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil Chemical Properties,Uses,Production
Originator
Ebrantil,Byk Gulden,W. Germany,1978
Uses
antihypertensive
Uses
Urapidil is used in preparation of Urapidil Hydrochloride crystal.It is used in diagnosis and treatment of hypertensive emergencies and urgencies among Italian emergency and intensive care departments.
Definition
ChEBI: Urapidil is a member of piperazines.
Manufacturing Process
20.6 g (0.083 mol) of N-(o-methoxyphenyl)-N'-(3-aminopropyl)-piperazine
and 15.7 g (0.09 mol) of 1,3-dimethyl-4-chlorouracil were boiled for 15 hours
in 100 ml triethylamine. The excess triethylamine was then distilled off in
vacuo and the residue was dissolved in 300 ml 1 N hydrochloric acid with
subsequent filtration. The filtrate thus obtained was cooled with ice and 2 N
aqueous ammonic solution was slowly added with stirring. As soon as the first
precipitation appeared, a few crystals of the desired product were added to
the solution. The ammoniacal suspension was stirred for one more hour, the
precipitate filtered off by suction and washed with 200 ml water.
The material was purified by recrystallization from ethanol with the addition of
activated carbon. In this manner 242 g 1,3-dimethyl-4-[γ-[4-(o_x0002_methoxyphenyl]-piperizinyl-(1)]propylamino] uracil having a melting point of
156°C were obtained corresponding to a yield of 75%. The purification may
also be effected by boiling the material in acetone to result in similar yields.
Therapeutic Function
Hypotensive
6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Heilongjiang Fuhe Pharmaceutical Group Co., Ltd. | -- | fuhejituan@163.com | China | 8 | 58 |
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | 18109298458 | jia@bohua.com | China | 46 | 58 |
| Chengdu Saint - Kay Biotechnology Co., Ltd. | 028-85157043 15882256948 | 676046971@qq.com | China | 4183 | 58 |
| BOYAN PHARMA | 18566078841 18566078841 | tanyan@boyanpharma.com | China | 109 | 58 |
| Jinan Xinwei Pharmaceutical Technology Co., LTD | 18354101831 13356699551 | 2067831699@qq.com | China | 100 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Boc Chemical Co.,Ltd | 021-34975603-808 18721111801 | sales@bocpharma.com | China | 991 | 64 |
View Lastest Price from 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Urapidil
34661-75-1
|
$33.00-68.00 | 99.98% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-27 | Urapidil
34661-75-1
|
$33.00-68.00 | 99.98% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-06-20 | Urapidil
34661-75-1
|
$10.00-40.00 | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. |
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