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PRUNASIN

PRUNASIN structure

CAS No.: 99-18-3

Chemical Name:: PRUNASIN

Synonyms: (r)-prunasin;Prunacin;PRUNASIN;d-prunasin;Noguro Sakura;Wild cherry glycoside;(r)-benzeneacetonitril;Prunasin (6CI, 7CI, 8CI);D-MANDELONITRILE B-D-GLUCOSIDE;D-Mandelonitrile β-D-glucoside

CBNumber:: CB9677133

Molecular Formula:: C14H17NO6

Molecular Weight:: 295.29

MDL Number:: MFCD00049232

MOL File:: 99-18-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:40:27

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PRUNASIN Properties

Melting point	138-148°C
Boiling point	527.0±50.0 °C(Predicted)
Density	1.45±0.1 g/cm3(Predicted)
storage temp.	Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Powder
pka	12.71±0.70(Predicted)
color	White to off-white
Stability	Hygroscopic
Major Application	metabolomics vitamins, nutraceuticals, and natural products
Cosmetics Ingredients Functions	SKIN CONDITIONING
InChI	InChI=1/C14H17NO6/c15-6-9(8-4-2-1-3-5-8)20-14-13(19)12(18)11(17)10(7-16)21-14/h1-5,9-14,16-19H,7H2/t9-,10+,11+,12-,13+,14+/s3
InChIKey	ZKSZEJFBGODIJW-OAWZEMCWNA-N
SMILES	O([C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@H](C1C=CC=CC=1)C#N \|&1:1,2,3,5,7,12,r\|
EWG's Food Scores	1
FDA UNII	14W4BPM5FB
UNSPSC Code	12352205
NACRES	NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301-H360

Precautionary statements

P201-P301+P310+P330

Hazard Codes

Risk Statements

36/37/38-25-60

Safety Statements

26-36/37/39-61-45

RIDADR

UN 2811 6.1 / PGIII

WGK Germany

RTECS

UL3420000

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Repr. 1B

NFPA 704

	0
2		0

PRUNASIN price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SMB00173	D-Mandelonitrile β-D-glucoside ≥90% (LC/MS-ELSD)	99-18-3	1mg	$527	2026-04-30	Buy
Cayman Chemical	15959	(R)-Prunasin ≥95%	99-18-3	500μg	$103	2026-04-30	Buy
Cayman Chemical	15959	(R)-Prunasin ≥95%	99-18-3	1mg	$183	2026-04-30	Buy
Cayman Chemical	15959	(R)-Prunasin ≥95%	99-18-3	5mg	$602	2026-04-30	Buy
TRC	TRC-P839000-5MG	(R)-Prunasin >95%(HPLC)	99-18-3	5mg	$549	2026-06-03	Buy

Product number	Packaging	Price	Buy
SMB00173	1mg	$527	Buy
15959	500μg	$103	Buy
15959	1mg	$183	Buy
15959	5mg	$602	Buy
TRC-P839000-5MG	5mg	$549	Buy

PRUNASIN Chemical Properties, Uses, Production

Description

(R)-Prunasin is a cyanogenic glucoside that is the precursor to amygdalin, a bitter component found in species of the genera Prunus and Olinia. It can be degraded to hydrogen cyanide, glucose, and benzaldehyde by the action of prunasin hydrolase and mandelonitrile lyase and possesses inhibitory effects on plant growth. (R)-Prunasin reportedly inhibits rat DNA polymerase β, which performs base excision repair required for DNA maintenance and replication, with an IC₅₀ value of 98 μM.

Chemical Properties

White Solid

Uses

Used in the synthesis of cyanogen glycoside. A component of antiperspirants, deodorants, body soaps, shampoos, hair rinses, and hair

Definition

ChEBI: (R)-prunasin is a prunasin.

Enzyme inhibitor

This cyanogenic glucoside (FW = 295.29 g/mol; CAS 99-18-3), also known as D(R)-mandelonitrile-b-D-glucoside, is readily obtained from amygdalin and is found in the pits of Prunus serotina. Prunasin is soluble in water and will give rise to prulaurasin (i.e., the diastereoisomeric mixture of DL(RS)- mandelonitrile-b-D-glucoside [i.e., prunasin and sambunigrin]). Target(s): DNA-directed DNA polymerase; DNA polymerase b; and a,a trehalase.

References

[1] RAQUEL SáNCHEZ-PéREZ. Prunasin hydrolases during fruit development in sweet and bitter almonds.[J]. Plant Physiology, 2012, 158 4: 1916-1932. DOI: 10.1104/pp.111.192021
[2] Y MIZUSHINA. The cyanogenic glucoside, prunasin (D-mandelonitrile-beta-D-glucoside), is a novel inhibitor of DNA polymerase beta.[J]. Journal of biochemistry, 1999, 126 2: 430-436. DOI: 10.1093/oxfordjournals.jbchem.a022468

PRUNASIN synthesis

Synthesis of PRUNASIN from Benzaldehyde

PRUNASIN Preparation Products And Raw materials

Raw materials

2,3,4,6-Tetra-O-acetyl-alpha-D-glucopyranosyl trichloroacetimidate (R)-Prunasin Tetraacetate (αR)-α-[(2,3,4,6-Tetra-O-acetyl-β-D-glucopyranosyl)oxy]benzeneacetamide Benzaldehyde

Preparation Products

D-arabino-hexosulose bis(phenylhydrazone) (R)-(+)-alpha-Hydroxybenzene-acetonitrile Malonic acid

PRUNASIN Suppliers

Global Suppliers ( 125)

Supplier	Tel	Email	Country	ProdList	Advantage
BioBioPha Co., Ltd.	0871-65217109	y.liu@mail.biobiopha.com	China	5641	65
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Chengdu Biopurify Phytochemicals Ltd.	+86-028-82633397 18982077548	cwb1@biopurify.cn	China	2376	60
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29977	65
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7717	56
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632;	sales@reading-chemicals.com	China	15165	58
Finetech Industry Limited	027-87465837 19945049750	sales@finetechnology-ind.com	China	9331	58
Shanghai Yongye Biotechnology Co., Ltd.	86-021-61559134 15921386130	3423497944@qq.com	China	8135	55

Supplier	Advantage
BioBioPha Co., Ltd.	65
J & K SCIENTIFIC LTD.	76
Chembest Research Laboratories Limited	61
Chemsky（shanghai）International Co.,Ltd.	50
Chengdu Biopurify Phytochemicals Ltd.	60
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
Sichuan Wei Keqi Biological Technology Co., Ltd.	56
Wuxi Zhongkun Biochemical Technology Co., Ltd.	58
Finetech Industry Limited	58
Shanghai Yongye Biotechnology Co., Ltd.	55

View Latest Price from PRUNASIN manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-24	PRUNASIN 99-18-3		1KG	99.0%	1000KG	Shaanxi Dideu Medichem Co. Ltd
2025-12-24	Methyl gallate 99-18-3		1KG	99.0%	1000KG	Shaanxi Dideu Medichem Co. Ltd
2024-11-28	Prunasin 99-18-3	$3500.00	1g	98	50 Kg	R&D Scientific Inc.

PRUNASIN
99-18-3
99.0%
Shaanxi Dideu Medichem Co. Ltd

Methyl gallate
99-18-3
99.0%
Shaanxi Dideu Medichem Co. Ltd

Prunasin
99-18-3
$3500.00
98
R&D Scientific Inc.

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AMYGDALIN TRIHYDRATE HOLOCALIN prunasin hydrolase

1of4

D-Mandelonitrile β-D-glucoside (R)-α-(β-D-Glucopyranosyloxy)benzeneacetonitrile (αR)-α-(β-D-Glucopyranosyloxy)-α-phenylacetonitrile [(αR)-α-Cyanobenzyl]β-D-glucopyranoside Prunacin (2R)-2-phenyl-2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyacetonitrile (2R)-2-phenyl-2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-ethanenitrile (2R)-2-phenyl-2-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-acetonitrile PENTAMETHYL-6-HYDROXYCHROMAN, 2,2,5,7,8-(RG) Benzeneacetonitrile, a-(b-D-glucopyranosyloxy)-, (aR)- D-MANDELONITRILE-BETA-D-GLUCOSIDE PRUNASIN (R)-(beta-D-glucopyranosyloxy)phenylacetonitrile D-MANDELONITRILE B-D-GLUCOSIDE (r)-alpha-(beta-d-glucopyranosyloxy)benzene-acetonitrile (r)-benzeneacetonitril d-prunasin Noguro Sakura Benzeneacetonitrile, α-(β-D-glucopyranosyloxy)-, (αR)- Wild cherry glycoside Prunasin (6CI, 7CI, 8CI) D-Mandelonitrile β-D-glucoside (R)-2-Phenyl-2-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)acetonitrile (r)-prunasin 99-18-3 Chiral Reagents Miscellaneous Natural Products Aromatics Carbohydrates & Derivatives