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1-Bromo-2,4,5-trifluorobenzene

1-Bromo-2,4,5-trifluorobenzene Structure
1-Bromo-2,4,5-trifluorobenzene structure
CAS No.
327-52-6
Chemical Name:
1-Bromo-2,4,5-trifluorobenzene
Synonyms
2,4,5-TRIFLUOROBROMOBENZENE;2,4,5 bromobenzene;1-Bromo-2,4,5-trifL;1-Bromo-2,4,5-triflu;2,4,5-TRIFLUOROBENZOBROMIDE;2,4,5-Trifluorophenyl bromide;1,2,4-Trifluoro-5-bromobenzene;2-BROMO-1,4,5-TRIFLUOROBENZENE;1-BROMO-2,4,5-TRIFLUOROBENZENE;5-Bromo-1,2,4-trifluorobenzene
CBNumber:
CB9696743
Molecular Formula:
C6H2BrF3
Molecular Weight:
210.98
MDL Number:
MFCD00000306
MOL File:
327-52-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:46:08
Product description Number Pack Size Price
1-Bromo-2,4,5-trifluorobenzene 99% 247979 5g $46.4
1-Bromo-2,4,5-trifluorobenzene >98.0%(GC) B1167 5g $27
1-Bromo-2,4,5-trifluorobenzene >98.0%(GC) B1167 25g $78
1-Bromo-2,4,5-trifluorobenzene FB46132 0.5kg $900
1-Bromo-2,4,5-trifluorobenzene FB46132 0.25kg $900
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1-Bromo-2,4,5-trifluorobenzene Properties

Melting point −19 °C(lit.)
Boiling point 144 °C(lit.)
Density 1.802 g/mL at 25 °C(lit.)
refractive index n20/D 1.485(lit.)
Flash point 132 °F
storage temp. 2-8°C
solubility water: insoluble
form clear liquid
Specific Gravity 1.81
color Colorless to Light yellow to Light orange
Water Solubility insoluble
BRN 1636588
InChI InChI=1S/C6H2BrF3/c7-3-1-5(9)6(10)2-4(3)8/h1-2H
InChIKey DVTULTINXNWGJY-UHFFFAOYSA-N
SMILES C1(Br)=CC(F)=C(F)C=C1F
CAS DataBase Reference 327-52-6(CAS DataBase Reference)
FDA UNII 5848WZ4MBL
NIST Chemistry Reference Benzene, 1-bromo-2,4,5-trifluoro-(327-52-6)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Warning
Hazard statements  H226-H315-H319-H335
Precautionary statements  P210-P233-P240-P241-P303+P361+P353-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,F
Risk Statements  36/37/38-10
Safety Statements  26-36/37/39-37/39-16
RIDADR  UN 1993 3/PG 3
WGK Germany  3
Hazard Note  Flammable
HazardClass  3
PackingGroup  III
HS Code  29039990
Storage Class 3 - Flammable liquids
Hazard Classifications Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
2 0

1-Bromo-2,4,5-trifluorobenzene price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 247979 1-Bromo-2,4,5-trifluorobenzene 99% 327-52-6 5g $46.4 2026-04-30 Buy
TCI Chemical B1167 1-Bromo-2,4,5-trifluorobenzene >98.0%(GC) 327-52-6 5g $27 2026-04-30 Buy
TCI Chemical B1167 1-Bromo-2,4,5-trifluorobenzene >98.0%(GC) 327-52-6 25g $78 2026-04-30 Buy
Biosynth FB46132 1-Bromo-2,4,5-trifluorobenzene 327-52-6 0.5kg $900 2026-06-04 Buy
Biosynth FB46132 1-Bromo-2,4,5-trifluorobenzene 327-52-6 0.25kg $900 2026-06-04 Buy
Product number Packaging Price Buy
247979 5g $46.4 Buy
B1167 5g $27 Buy
B1167 25g $78 Buy
FB46132 0.5kg $900 Buy
FB46132 0.25kg $900 Buy

1-Bromo-2,4,5-trifluorobenzene Chemical Properties,Uses,Production

Chemical Properties

clear slightly yellow liquid

Uses

1-Bromo-2,4,5-trifluorobenzene is the intermediate of liquid crystals. The derivatives of this compound can be used as intermediates for the synthesis of qunolone antibacterial. It is employed in the synthesis of 3-ethenyl, 3-ethynyl, 3-aryl, and 3-cyclopropyl-2, 4, 5-trifluorobenzoic acids from 1-bromo-2, 4, 5-trifluorobenzene and 2, 4, 5-trifluoro-3-hydroxybenzoic acid.

Uses

Intermediates of Liquid Crystals

Definition

ChEBI: 1-Bromo-2,4,5-trifluorobenzene is an organofluorine compound.

General Description

1-Bromo-2,4,5-trifluorobenzene undergoes Br-Mg-exchange reaction with i-PrMgBr in THF to yield organomagnesium compound.

Synthesis

1,2,4-Trifluorobenzene

367-23-7

1-Bromo-2,4,5-trifluorobenzene

327-52-6

The general procedure for the synthesis of 2,4,5-trifluorobromobenzene from 1,2,4-trifluorobenzene was as follows: 100 g of 1,2,4-trifluorobenzene and 3 g of tin tetrachloride-polystyrene complex were added to a 500 mL three-necked flask, and glacial acetic acid was used as the reaction solvent. At room temperature, 127 mL of liquid bromine was added slowly and dropwise. The reaction lasted for 2 h, during which the progress of the reaction was monitored by thin-layer chromatography (TLC), and after confirming that the ingredients were fully reacted, vacuum evaporation was performed to remove the glacial acetic acid. Subsequently, 500 mL of chloroform was added and the organic phase was washed with 3% dilute hydrochloric acid, followed by the addition of saturated sodium sulfite solution to remove residual bromine from the organic phase. After sequential washing, the organic phase was washed with saturated saline. Finally, the solvent was removed by distillation to afford 158 g of 2,4,5-trifluorobromobenzene in 98.7% yield and 99.6% purity as shown by gas chromatography analysis.

References

[1] Patent: CN107673951, 2018, A. Location in patent: Paragraph 0015; 0016; 0017; 0018
[2] Journal of the American Chemical Society, 1951, vol. 73, p. 153
[3] Journal of the American Chemical Society, 1959, vol. 81, p. 94,98

1-Bromo-2,4,5-trifluorobenzene Preparation Products And Raw materials

Raw materials

1,2,4-Trifluorobenzene

Preparation Products

2,4,5-Trifluorophenylacetic acid (R)-3-AMino-4-(2,4,5-trifluoro-phenyl)-butyric acid hydrochloride Sitagliptin N-Boc IMpurity Carbamic acid, N-[(1R)-3-hydroxy-1-[(2,4,5-trifluorophenyl)methyl]propyl]-, 1,1-dimethylethyl ester

1-Bromo-2,4,5-trifluorobenzene Suppliers

Global( 388)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5224 58
Anhui Zhongda Biotechnology Co., Ltd 		+8619956560829 justine@zhongda-biotech.com China 286 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20121 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 810 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21585 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29812 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Anhui Zhongda Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Hi-Tech Chemistry Corp 		58
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58

View Lastest Price from 1-Bromo-2,4,5-trifluorobenzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-Bromo-2,4,5-trifluorobenzene pictures 2026-07-09 1-Bromo-2,4,5-trifluorobenzene
327-52-6
 $1.00-100.00 1KG 99% Henan Fengda Chemical Co., Ltd
1-Bromo-2,4,5-trifluorobenzene pictures 2026-05-28 1-Bromo-2,4,5-trifluorobenzene
327-52-6
 $10.00 1KG 99% 10 ton Hebei Chuanghai Biotechnology Co,.LTD
1-Bromo-2,4,5-trifluorobenzene pictures 2026-03-20 1-Bromo-2,4,5-trifluorobenzene
327-52-6
 $1.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd

1-Bromo-2,4,5-trifluorobenzene Spectrum

1-Bromo-2,4,5-trifluorobenzene(327-52-6)MS1-Bromo-2,4,5-trifluorobenzene(327-52-6)1HNMR1-Bromo-2,4,5-trifluorobenzene(327-52-6)13CNMR1-Bromo-2,4,5-trifluorobenzene(327-52-6)IR1

327-52-6(1-Bromo-2,4,5-trifluorobenzene)Related Search:

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1-Bromo-2,4,6-trifluorobenzene 1-BROMO-2,3,6-TRIFLUOROBENZENE

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2,4,5-Trifluorobromobenzene 99% 1-BROMO-2,4,5-TRIFLUOROBENZENE 2,4,5-TRIFLUOROBENZOBROMIDE 2-BROMO-1,4,5-TRIFLUOROBENZENE Two, four, five, three fluorine broMobenzene 2,4,5 bromobenzene 1-Bromo-2,4,5-trifluorobenzene 99% 1-Bromo-2,4,5-trifluorobenzene99% 1-BROMO-2,4,5-TRIFLUOROBENZENE 98+% 2,4,5-Trifluorophenyl bromide 1,2,4-Trifluoro-5-bromobenzene 1-Bromo-2,4,5-triflu 5-Bromo-1,2,4-trifluorobenzene 1-Bromo-2,4,5-trifluorobenzene> 1-Bromo-2,4,5-trifL Benzene, 1-bromo-2,4,5-trifluoro- 1-Bromo-2,4,5-trifluorobenzene ISO 9001：2015 REACH 1-Bromo-2,4,4-trifluorobenzene 2,4,5-TRIFLUOROBROMOBENZENE 327-52-6 37-52-6 372-52-6 Halogenated Hydrocarbons Organic Building Blocks Building Blocks Aryl C6 Benzenes Aryl Halogenated Hydrocarbons Miscellaneous Aromatic Hydrocarbons (substituted) & Derivatives C6