2,4,5-Trifluorophenylacetic acid
- CAS No.
- 209995-38-0
- Chemical Name:
- 2,4,5-Trifluorophenylacetic acid
- Synonyms
- 2,4,5-Trifluoropheny;2,4,5-Trifluorophenylacetic acid ,99%;RETAG-001;RARECHEM AL BO 0510;2,4,5-Trifluoropheny245;Trifluorophenylacetic Aci;trifluorophenylacetic acid;5-Trifluorophenylacetic acid;2,4,5-trifluoropheylacetic acid;2,4,5-trfluorophenylacetic acid
- CBNumber:
- CB6283207
- Molecular Formula:
- C8H5F3O2
- Molecular Weight:
- 190.12
- MDL Number:
- MFCD00082479
- MOL File:
- 209995-38-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 121-125 °C |
|---|---|
| Boiling point | 255.0±35.0 °C(Predicted) |
| Density | 1.468±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.78±0.10(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C8H5F3O2/c9-5-3-7(11)6(10)1-4(5)2-8(12)13/h1,3H,2H2,(H,12,13) |
| InChIKey | YSQLGGQUQDTBSL-UHFFFAOYSA-N |
| SMILES | C1(CC(O)=O)=CC(F)=C(F)C=C1F |
| CAS DataBase Reference | 209995-38-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 37/38-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2,4,5-Trifluorophenylacetic acid price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 684155 | 2,4,5-Trifluorophenylacetic acid 97% | 209995-38-0 | 1g | $70.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 684155 | 2,4,5-Trifluorophenylacetic acid 97% | 209995-38-0 | 5g | $90.6 | 2026-04-30 | Buy |
| TCI Chemical | T2407 | 2,4,5-Trifluorophenylacetic Acid >98.0%(GC)(T) | 209995-38-0 | 5g | $35 | 2026-04-30 | Buy |
| TRC | TRC-T792625-1G | 2,4,5-Trifluorobenzeneacetic Acid | 209995-38-0 | 1g | $70 | 2026-06-03 | Buy |
| Biosynth | FT38245 | 2,4,5-Trifluorophenylacetic acid | 209995-38-0 | 0.25kg | $265.37 | 2026-06-04 | Buy |
2,4,5-Trifluorophenylacetic acid Chemical Properties,Uses,Production
Description
2,4,5-Trifluorophenylacetic acid is a fluorophenylacetic acid, which is a valuable intermediate for preparing various pharmacologically active compounds. In particular, trifluorophenylacetic acids are used to prepare inhibitors of the dipeptidyl peptidase-4 enzyme. These medicines are helpful in treating diabetes, in particular type 2 diabetes. One of these active ingredients is Sitagliptin, available commercially under the brand name Januvia, which uses 2,4,5-trifluorophenylacetic acid as a critical intermediate for its synthesis.
Chemical Properties
White to light brown solid
Uses
2,4,5-Trifluorobenzeneacetic Acid is used in the synthesis of EGFR/ErbB-2-kinase inhibitors. Also used in the synthesis of new imidazopyrazinone derivatives as potnetial dipeptidyl peptidase IV inhibitors.
Application
2,4,5-Trifluorophenylacetic acid is used to synthesize the intermediate of sitagliptin, a new drug for the treatment of type II diabetes. sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor newly launched by Merck. It has good curative effect, small side effects, good safety and tolerance in treating type II diabetes.
Preparation
synthesis of 2,4,5-trifluorophenylacetic acid: A 100 mL flask was charged 10.0 g of 2,4,5-trifluoromandelic acid, 23.9 g of H3PO3 (6 eq.), 0.73 g of Nal (0.1 eq.) and 0.47 g (0.10 eq.) of MSA. The obtained mixture was stirred at 95-105°C for 24 hrs. Once the conversion is completed (by HPLC; conversion > 99%, typically achieved after 24 hours), the mixture is cooled to room temperature, and 20 mL of methyl tert-butyl ether were added and then 20 mL of water where added. The obtained mixture was stirred for 5 min, then the organic layers were separated. Then 10 mL of methyl tert-butyl ether was added to the aqueous layers, stirred for 5 min, then the phase were separated. The organic layers were combined. The combined organic layers were concentrated under vacuum at 35°C, to provide crude 2,4,5-trifluorophenylacetic acid(TFPAA). To the obtained crude TFPAA was recrystallized from toluene, to obtain TFPAA, as a white crystals, 6.4 g, molar yield 69.5%, chemical purity of HPLC 99.47% A/A%
2,4,5-Trifluorophenylacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang Jiuzhou Pharmaceutical Co., Ltd | 13566413511 | le.sun@jiuzhoupharma.com | China | 38 | 58 |
| Shanghai Fengji Pharmaceutical Technology Co., Ltd | 15555063509 | 153666767@qq.com | China | 2750 | 58 |
| Hunan Furui Biopharma Technology Co., Ltd. | 15901640172，19275032510 15901640172 | sales03@hn-furui.com | China | 380 | 55 |
| Suzhou Highfine Biotech Co., Ltd | 0512-69209928 18796809688 | zhouyingxiang@highfine.com | China | 1845 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Danyang Wanlong Chemical Co., Ltd | 86-511-8681 0993 | jeff@wanlongchem.com | China | 63 | 55 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
Related articles
- Synthesis and Condensation Reaction of 2,4,5-Trifluorophenylacetic acid
- 2,4,5-Trifluorophenylacetic acid is a phenylacetic acid derivative, which can be used for the synthesis of sitagliptin.
- Dec 22,2025
View Lastest Price from 2,4,5-Trifluorophenylacetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | 2,4,5-Trifluorophenylacetic acid
209995-38-0
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-02 | 2,4,5-Trifluorophenylacetic acid
209995-38-0
|
$8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 2,4,5-Trifluorophenylacetic acid
20995-38-0
|
$1.10 | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited |
-
- 2,4,5-Trifluorophenylacetic acid
209995-38-0
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 2,4,5-Trifluorophenylacetic acid
209995-38-0
- $8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2,4,5-Trifluorophenylacetic acid
20995-38-0
- $1.10
- 99.9%
- Dideu Industries Group Limited
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