Pilsicainide hydrochloride
- CAS No.
- 88069-49-2
- Chemical Name:
- Pilsicainide hydrochloride
- Synonyms
- Pilsinic;Rizumcote;Alisrythm;Tatsupilljin;PILSICAININIDE;Pilsicainide hydrochoride;Pilsicainide-Hydrochlordie;Pilzicainide hydrochloride;PILSICAINIDE HYDROCHLORIDE;Pilsicainide HCl, 10 mM in DMSO
- CBNumber:
- CB9699294
- Molecular Formula:
- C17H24N2O
- Molecular Weight:
- 272.39
- MDL Number:
- MFCD00903769
- MOL File:
- 88069-49-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 212-214° |
|---|---|
| storage temp. | room temp |
| solubility | Chloroform (Slightly), Water (Slightly) |
| form | powder |
| color | white to beige |
| Water Solubility | deionized water: >5mg/mL |
| InChI | 1S/C17H24N2O.ClH/c1-13-6-3-7-14(2)16(13)18-15(20)12-17-8-4-10-19(17)11-5-9-17;/h3,6-7H,4-5,8-12H2,1-2H3,(H,18,20);1H |
| InChIKey | NZOSVDHCTCLGEB-UHFFFAOYSA-N |
| SMILES | Cl.Cc1cccc(C)c1NC(=O)CC23CCCN2CCC3 |
| FDA UNII | 03C8I9296V |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933.99.7000 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| Toxicity | LD50 in mice (mg/kg): 410 s.c. (Miyano, 1985) | |||||||||
| NFPA 704 |
|
Pilsicainide hydrochloride price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P0026 | Pilsicainide hydrochloride ≥98% (HPLC) | 88069-49-2 | 10MG | $111 | 2026-04-30 | Buy |
| Sigma-Aldrich | P0026 | Pilsicainide hydrochloride ≥98% (HPLC) | 88069-49-2 | 50MG | $432 | 2026-04-30 | Buy |
| TCI Chemical | P2634 | Pilsicainide Hydrochloride | 88069-49-2 | 50MG | $72 | 2026-04-30 | Buy |
| TCI Chemical | P2634 | Pilsicainide Hydrochloride | 88069-49-2 | 250MG | $213 | 2026-04-30 | Buy |
| Cayman Chemical | 34242 | Pilsicainide (hydrochloride) ≥95% | 88069-49-2 | 25mg | $81 | 2026-04-30 | Buy |
Pilsicainide hydrochloride Chemical Properties, Uses, Production
Description
Pilsicainide hydrochloride is a new pynolizidine lidocaine derivative with antiarrhythmic activity. It is the first pharmaceutical product introduced by Suntory and was solely developed in Japan. The compound is reported to be highly effective in the treatment of premature ventricular contraction. It has no anticholinergic or CNS activity and is not as likely as other class 1C antiarrhythmics to have restricted indications.
Originator
Suntory (Japan)
Uses
Pilsicainide hydrochloride has been used as a sodium channel blocker:
- to study its effects on electrophysiological parameters in guinea pig pulmonary vein preparation
- to study its effects on Ca2+release and arrhythmic events in Andersen-Tawil syndrome induced pluripotent stem cells (ATS-iPSC)-derived cardiomyocytes
- to study its electrophysiological effects on the guinea pig atrium
brand name
Sunrhythm
Biochem/physiol Actions
Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na+1 channels. Pilsicainide was defined as a pure sodium channel blocker. The compound is classified as a class Ic antiarrhythmic drug, and was originally developed in Japan. Similar to Lidocaine, Pilsicainide binds to open channels, but slowly. Pilsicainide is capable of selectively blocking the late currents in the mutant Na(+) channels that show dominant abnormal burst openings such as in δKPQ mutants. The compound is used to induce Brugada syndrome (BS) in animal models.
Pilsicainide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| Hunan Furui Biopharma Technology Co., Ltd. | 15901640172，19275032510 15901640172 | sales03@hn-furui.com | China | 380 | 55 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
| HBCChem, Inc. | +1-510-219-6317 | sales@hbcchem.com | United States | 10628 | 60 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from Pilsicainide hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Pilsicainide HCl
88069-49-2
|
$31.00-89.00 | 99.76% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-02-02 | Pilsicainide hydrochloride
88069-49-2
|
$1.00 | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | Pilsicainide hydrochloride
88069-49-2
|
$1.00 | 1g | 99% | 100KG | Career Henan Chemical Co |
-
- Pilsicainide HCl
88069-49-2
- $31.00-89.00
- 99.76%
- TargetMol Chemicals Inc.
-
- Pilsicainide hydrochloride
88069-49-2
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Pilsicainide hydrochloride
88069-49-2
- $1.00
- 99%
- Career Henan Chemical Co
