Pilsinic;Rizumcote;Alisrythm;Tatsupilljin;PILSICAININIDE;Pilsicainide hydrochoride;Pilsicainide-Hydrochlordie;Pilzicainide hydrochloride;PILSICAINIDE HYDROCHLORIDE;Pilsicainide HCl, 10 mM in DMSO
6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications
Acute Tox. 3 Oral
독성
LD50 in mice (mg/kg): 410 s.c. (Miyano, 1985)
그림문자(GHS):
신호 어:
Danger
유해·위험 문구:
암호
유해·위험 문구
위험 등급
범주
신호 어
그림 문자
P- 코드
H301
삼키면 유독함
급성 독성 물질 - 경구
구분 3
위험
P264, P270, P301+P310, P321, P330,P405, P501
예방조치문구:
P264
취급 후에는 손을 철저히 씻으시오.
P264
취급 후에는 손을 철저히 씻으시오.
P270
이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P310
삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P405
밀봉하여 저장하시오.
P501
...에 내용물 / 용기를 폐기 하시오.
NFPA 704
0
2
0
필시카이니드히드로클로라이드 C화학적 특성, 용도, 생산
개요
Pilsicainide hydrochloride is a new pynolizidine lidocaine derivative with
antiarrhythmic activity. It is the first pharmaceutical product introduced by Suntory
and was solely developed in Japan. The compound is reported to be highly effective in
the treatment of premature ventricular contraction. It has no anticholinergic or CNS
activity and is not as likely as other class 1C antiarrhythmics to have restricted
indications.
용도
Pilsicainide hydrochloride has been used as a sodium channel blocker:
to study its effects on electrophysiological parameters in guinea pig pulmonary vein preparation
to study its effects on Ca2+release and arrhythmic events in Andersen-Tawil syndrome induced pluripotent stem cells (ATS-iPSC)-derived cardiomyocytes
to study its electrophysiological effects on the guinea pig atrium
