Pamidronate disodium salt
- CAS No.
- 57248-88-1
- Chemical Name:
- Pamidronate disodium salt
- Synonyms
- PAMIDRONATE;cgp23339a;CGP 23339AE;PAMIDRONICDISODIUMSALT;PaMidronate DisodiuM API;Pamidronate disodium salt;Disodium Pamidronate Pamidronate (sodium salt);Disodium Pamidronate Hydrate;Pamidronate disodium hydrate
- CBNumber:
- CB9707409
- Molecular Formula:
- C3H12NNaO7P2
- Molecular Weight:
- 259.07
- MDL Number:
- MFCD01938386
- MOL File:
- 57248-88-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 300 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: 28 mg/mL |
| form | solid |
| color | white |
| Water Solubility | H2O: 28mg/mL |
| Merck | 14,7003 |
| Stability | Hygroscopic |
| InChI | 1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2 |
| InChIKey | TVQNUQCYOOJTMK-UHFFFAOYSA-L |
| SMILES | O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O |
| CAS DataBase Reference | 57248-88-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | C7S8VWP5DH |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-48-41-37/38-20/21/22 | |||||||||
| Safety Statements | 22-26-36/37/39-45 | |||||||||
| RIDADR | 3077 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | SZ6525000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
Pamidronate disodium salt price More Price(85)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P2371 | Pamidronate disodium salt hydrate ≥95% (NMR), solid | 57248-88-1 | 10mg | $147 | 2026-04-30 | Buy |
| Sigma-Aldrich | P2371 | Pamidronate disodium salt hydrate ≥95% (NMR), solid | 57248-88-1 | 100mg | $679 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP615 | Disodium pamidronate British Pharmacopoeia (BP) Reference Standard | 57248-88-1 | 100MG | $301 | 2026-04-30 | Buy |
| TCI Chemical | D3921 | Disodium Pamidronate Hydrate >97.0%(T) | 57248-88-1 | 100mg | $38 | 2026-04-30 | Buy |
| TCI Chemical | D3921 | Disodium Pamidronate Hydrate >97.0%(T) | 57248-88-1 | 1g | $173 | 2026-04-30 | Buy |
Pamidronate disodium salt Chemical Properties,Uses,Production
Description
Disodium pamidronate is a calcium metabolism regulator useful in the treatment of hypercalcemia associated with malignancy. It presumably reduces the bone resorption of calcium by inhibiting the formation and attachment of osteoclasts. Other potential uses include osteoporosis and calcitonin-resistant Paget’s disease.
Chemical Properties
White Crystals
Originator
Henkel (United Kingdom)
Uses
A bisphosphonate antiresorptive agent; bone resorption inhibitor.
Uses
Pamidronate disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis. It is used to prevent bone loss, and treat osteoporosis.
Uses
A farnesyl diphosphate synthase inhibitor
Manufacturing Process
For a batch size of 5 L, 587.5 g (3.2 moles) of mannitol is dissolved in 3.5 L of water. Pamidronic acid (31.6 g, 0.133 moles) is mixed with a 1.0 L aliquot of the mannitol solution to form a slurry. The slurry is then transferred into the remainder of the mannitol solution, and stirred for at least 15 min. Aqueous 1 N sodium hydroxide (270 ml) is then added and the mixture is stirred until a clear, colorless solution results. The pH is then adjusted to 6.50.1 using either 1 M aqueous phosphoric acid or 1 N aqueous sodium hydroxide, as needed. The solution is then filtered through a 0.22 micron filter, and filled at 20°C into vials at 4.0 ml (4.172 g)/vial, under sterile conditions. The aqueous solution is frozen at -37°C and lyophilized (20 mbar, 20°-40°C) to yield 1,250 vials, each containing 30 mg of amorphous disodium pamidronate. The vials are sealed under positive nitrogen pressure. The disodium pamidronate is amorphous (noncrystalline) by X-ray diffraction and contains 0.7 wt-% water.
brand name
Aredia (Novartis).
Therapeutic Function
Bone resorption suppressant
Biochem/physiol Actions
Pamidronate disodiumhas the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.
Veterinary Drugs and Treatments
Pamidronate may be useful in treating hypercalcemia associated with vitamin D-related toxicoses or hypercalcemia of malignancy. There is ongoing research on the use of this drug to determine if it has clinical usefulness in directly treating “micro-metastases” in osteosarcomas.
Pamidronate disodium salt Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
View Lastest Price from Pamidronate disodium salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Pamidronate disodium salt USP/EP/BP
57248-88-1
|
$1.10 | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2026-07-27 | Pamidronate Disodium
57248-88-1
|
$36.00-82.00 | 99.94% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-27 | Pamidronate Disodium
57248-88-1
|
$36.00-82.00 | 99.94% | 10g | TargetMol Chemicals Inc. |
-
- Pamidronate disodium salt USP/EP/BP
57248-88-1
- $1.10
- 99.9%
- Dideu Industries Group Limited
-
- Pamidronate Disodium
57248-88-1
- $36.00-82.00
- 99.94%
- TargetMol Chemicals Inc.
-
- Pamidronate Disodium
57248-88-1
- $36.00-82.00
- 99.94%
- TargetMol Chemicals Inc.
