3-(2H-Tetrazol-5-yl)-pyridine
- CAS No.
- 3250-74-6
- Chemical Name:
- 3-(2H-Tetrazol-5-yl)-pyridine
- Synonyms
- DK7403;Lu 31-102;AKOS B020828;BUTTPARK 14\02-73;CBI-BB ZERO/005386;IFLAB-BB F2124-0755;ART-CHEM-BB B020828;5-β-Pyridyltetrazole;SPECS AO-289/25117008;5-(3-PYRIDYL)TETRAZOLE
- CBNumber:
- CB9709382
- Molecular Formula:
- C6H5N5
- Molecular Weight:
- 147.14
- MDL Number:
- MFCD00665795
- MOL File:
- 3250-74-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 240 °C |
|---|---|
| Boiling point | 379.4±44.0 °C(Predicted) |
| Density | 1.388±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | solid |
| pka | 5.99±0.12(Predicted) |
| Appearance | White to off-white Solid |
| Water Solubility | Soluble in water (slightly). |
| InChI | InChI=1S/C6H5N5/c1-2-5(4-7-3-1)6-8-10-11-9-6/h1-4H,(H,8,9,10,11) |
| InChIKey | SECHDFHDDVELCV-UHFFFAOYSA-N |
| SMILES | C1=NC=CC=C1C1=NNN=N1 |
| CAS DataBase Reference | 3250-74-6(CAS DataBase Reference) |
| FDA UNII | ZC84PPS834 |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338-P280d | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38-22 | |||||||||
| Safety Statements | 26-36/37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT-HARMFUL | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 13 - Non Combustible Solids | |||||||||
| Hazard Classifications | Eye Dam. 1 | |||||||||
| REACH Registrations | Inactive | |||||||||
| NFPA 704 |
|
3-(2H-Tetrazol-5-yl)-pyridine price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 50967 | 3-(1H-TETRAZOL-5-YL)PYRIDINE 97% | 3250-74-6 | 1G | $100 | 2026-04-30 | Buy |
| AstaTech | 50967 | 3-(1H-TETRAZOL-5-YL)PYRIDINE 97% | 3250-74-6 | 5G | $299 | 2026-04-30 | Buy |
| AstaTech | 50967 | 3-(1H-TETRAZOL-5-YL)PYRIDINE 97% | 3250-74-6 | 10G | $449 | 2026-04-30 | Buy |
| Biosynth | DAA25074 | 5-(3-Pyridyl)-1H-tetrazole | 3250-74-6 | 5g | $472 | 2026-06-04 | Buy |
| Activate Scientific | AS42847 | 3-(2H-Tetrazol-5-yl)pyridine 98% | 3250-74-6 | 1g | $116 | 2026-06-04 | Buy |
3-(2H-Tetrazol-5-yl)-pyridine Chemical Properties, Uses, Production
Uses
5-(3-Pyridyl)-1H-tetrazole is used as a pharmaceutical intermediate. The Pyridine,3-(2H-tetrazol-5-yl)- acts as reactant with 1-(4-bromo-phenyl)-3-piperidino-propan-1-one, hydrochloride, and obtain the 1-(4-bromo-phenyl)-3-(5-pyridin-3-yl-tetrazol-2-yl)-propan-1-one. This reaction needs the solvent of dimethylformamide. The yield is 31%. In addition, this reaction should be taken for 8 hours at the temperature of 150°C.
Synthesis
100-54-9
3250-74-6
The general procedure for the synthesis of 5-(3-pyridinyl)-1H-tetrazole from 3-cyanopyridine was as follows: 3-cyanopyridine (2 mmol), sodium azide (2.4 mmol, 1.2 eq.), and tetrabutylammonium bromide (2.4 mmol, 1.2 eq.) were added to a vial with a screw cap. The reaction mixture was stirred at 105 °C and the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to room temperature and dissolved in deionized water (5 mL). Subsequently, the aqueous solution was acidified with 1 M hydrochloric acid to pH = 3. If precipitate formation was observed, the suspension was filtered and the filter cake was washed with deionized water to obtain a pure product. If no precipitate formation was observed, the aqueous solution was extracted with ethyl acetate (3 x 4 mL). The organic phases were combined, washed with 1 M hydrochloric acid (3 x 4 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the pure product.
References
[1] Journal of Heterocyclic Chemistry, 2010, vol. 47, # 4, p. 913 - 922
[2] Polyhedron, 2011, vol. 30, # 15, p. 2606 - 2610
[3] Mendeleev Communications, 2011, vol. 21, # 6, p. 334 - 336
[4] European Journal of Organic Chemistry, 2014, vol. 2014, # 2, p. 436 - 441
3-(2H-Tetrazol-5-yl)-pyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou Edward Biology Co.,Ltd | 0371-63682289 15538176268 | jacschem@163.com | China | 9985 | 58 |
| Shanghai Tombiopharma Chemical Co. Ltd. | 13391076197 | tombiopharma@163.com | China | 4986 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Shanghai Litong Chemical Technology Co.,Ltd. | 13598610367 0373-7129549 | 2468833170@qq.com | China | 932 | 58 |
View Latest Price from 3-(2H-Tetrazol-5-yl)-pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-28 | 3-(2H-TETRAZOL-5-YL)-PYRIDINE
3250-74-6
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2024-07-11 | 3-(2H-TETRAZOL-5-YL)-PYRIDINE
3250-74-6
|
$1.00 | 1Kg | 98% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- 3-(2H-TETRAZOL-5-YL)-PYRIDINE
3250-74-6
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3-(2H-TETRAZOL-5-YL)-PYRIDINE
3250-74-6
- $1.00
- 98%
- Shaanxi Dideu Medichem Co. Ltd
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