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(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester

(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester structure

CAS No.: 314741-39-4

Chemical Name:: (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester

Synonyms: 1-(tert-butyl) 3-methyl (S)-piperazine-1,3-dicarboxylate;(S)-4-Boc-piperazine-2-carboxylic a;Methyl (S)-4-Boc-piperazine-2-carboxylate;Methyl (S)-1-Boc-piperazine-3-carboxylate;S-1-Boc-piperazine-3-carboxylic acid Methyl ester;(S)-N-Boc-3-piperazinecarboxylic acid Methyl ester;(S)-tert-butyl methyl piperazine-1,3-dicarboxylate;(S)-4-Boc-Piperazine-2-carboxylic acid methyl ester;(S)-N4-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER;(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester

CBNumber:: CB2947844

Molecular Formula:: C11H20N2O4

Molecular Weight:: 244.29

MDL Number:: MFCD04115326

MOL File:: 314741-39-4.mol

MSDS File:: SDS

Last updated:2026-05-28 00:52:48

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(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester Properties

Boiling point	321.3±37.0 °C(Predicted)
Density	1.118±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	6.45±0.40(Predicted)
Appearance	Off-white to light yellow Solid
InChI	InChI=1S/C11H20N2O4/c1-11(2,3)17-10(15)13-6-5-12-8(7-13)9(14)16-4/h8,12H,5-7H2,1-4H3/t8-/m0/s1
InChIKey	QUKAHFCVKNRRBU-QMMMGPOBSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCN[C@H](C(OC)=O)C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS02
Signal word	Danger
Hazard statements	H315-H319-H228
Precautionary statements	P240-P210-P241-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313
HS Code	2933599590

(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	66878	(S)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER 97%	314741-39-4	0.5G	$10	2026-04-30	Buy
AstaTech	66878	(S)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER 97%	314741-39-4	1G	$18	2026-04-30	Buy
AstaTech	66878	(S)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER 97%	314741-39-4	5G	$49	2026-04-30	Buy
Apolloscientific	OR308068	1-tert-Butyl 3-methyl (3S)-piperazine-1,3-dicarboxylate 97%	314741-39-4	1g	$35	2026-06-04	Buy
Apolloscientific	OR308068	1-tert-Butyl 3-methyl (3S)-piperazine-1,3-dicarboxylate 97%	314741-39-4	5g	$107	2026-06-04	Buy

Product number	Packaging	Price	Buy
66878	0.5G	$10	Buy
66878	1G	$18	Buy
66878	5G	$49	Buy
OR308068	1g	$35	Buy
OR308068	5g	$107	Buy

(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester Chemical Properties, Uses, Production

Synthesis

1,2,4-Piperazinetricarboxylic acid,4-(1,1-dimethylethyl)2-methyl1-(phenylmethyl)ester,(2S)-

314741-38-3

(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester

314741-39-4

Step 3: Synthesis of 3-tert-butyl 3-methyl(S)-piperazine dicarboxylate (AA3); 10% Pd-C (0.2 eq.) was added to a stirred methanolic solution (0.1 M) of AA 2 at room temperature. The reaction mixture was placed under hydrogen atmosphere and stirred at room temperature for 3 hours. After completion of the reaction, the mixture was filtered and the filter cake was washed with methanol. The filtrate was concentrated under reduced pressure to afford the target product methyl (S)-1-N-Boc-3-piperazinecarboxylate in 89% yield. The product was confirmed by 1H NMR (400 MHz, CDCl3,300K): δ 4.05 (1H, m), 3.76 (3H, s), 3.74-3.68 (1H, m), 3.44 (1H, dd, J = 8.6,3.5 Hz), 3.30-3.12 (1H, m), 3.10-3.00 (2H, m), 2.75 ( 1H, m), 2.17-1.74 (1H, m), 1.47 (9H, s). Mass spectrometry analysis (ES +) showed that the theoretical molecular weight of C11H20N2O4 was 244 and the measured value was 267 (M + Na)+.

References

[1] Patent: WO2010/23480, 2010, A1. Location in patent: Page/Page column 41
[2] Patent: US2003/203917, 2003, A1
[3] Patent: EP1187828, 2004, B1. Location in patent: Page 12

(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

1,2,4-Piperazinetricarboxylic acid,4-(1,1-dimethylethyl)2-methyl1-(phenylmethyl)ester,(2S)- Methanol Hydrogen

Preparation Products

(S)-1-Boc-3-hydroxymethyl-piperazine

(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester Suppliers

Global Suppliers ( 151)

Supplier	Tel	Email	Country	ProdList	Advantage
Pharmavoyager	15351203386	2592141051@qq.com	China	93	55
Chengdu Firster Pharmaceutical Co., Ltd.	028-87078428 028-87074958	chengzhenyong@cdfirster.com	China	2580	60
Chengdu Firster Pharmaceutical Co., Ltd.	19138996873	670603485@qq.com	China	196	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Sichuan Guanghan Bio-Tech Co., Ltd	+86-28-86127071	info@sino-produce.com	China	400	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64

Supplier	Advantage
Pharmavoyager	55
Chengdu Firster Pharmaceutical Co., Ltd.	60
Chengdu Firster Pharmaceutical Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Chembest Research Laboratories Limited	61
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Sichuan Guanghan Bio-Tech Co., Ltd	66
Pure Chemistry Scientific Inc.	62
Accela ChemBio Co.,Ltd.	64

View Latest Price from (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-08-09	(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester 314741-39-4	$8.80	1KG	97%-99%	100kg	Career Henan Chemical Co

(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester
314741-39-4
$8.80
97%-99%
Career Henan Chemical Co

(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester Spectrum

(S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester(314741-39-4)¹HNMR

314741-39-4 ((S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester) Related Search:

(S)-1-Boc-3-hydroxymethyl-piperazine (S)-Piperazine-2-carboxylic acid (R)-1-Boc-3-methylpiperazine (S)-4-N-Boc-piperazine-2-carboxylic acid Methyl 4-Boc-piperazine-2-carboxylate

4-Boc-piperazine-2-carboxylic acid (S)-1-N-Boc-piperazine-2-carboxylic acid methyl ester (R)-4-N-Boc-piperazine-2-carboxylic acid methyl ester N-Boc-piperazine-2-carboxylic acid methyl ester (R)-N-Boc-piperazine-2-carboxylic acid methyl ester

N-4-Boc-2-piperazinecarboxylic acid (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester 3-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-alanine methyl ester 3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 2-Piperazinecarboxylic acid methyl ester

2-Piperazinecarboxylicacid,methylester,(S)-(9CI) 1-Piperazinecarboxaldehyde,3-methyl-,(3R)-(9CI) (S)-Piperazine-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester HCl

1of4

(S)-1-N-Boc-piperazine-3-carboxylic acid methyl ester (S)-N4-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL ESTER (S)-4-Boc-Piperazine-2-carboxylic acid methyl ester Methyl (S)-4-Boc-piperazine-2-carboxylate (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester REF DUPL: (S)-4-N-Boc-piperazine-2-carboxylic acid methyl ester (S)-4-Boc-piperazine-2-carboxylic a 1-tert-butyl 3-methyl (3R)-piperazine-1,3-dicarboxylate 1-tert-butyl 3-methyl (3S)-piperazine-1,3-dicarboxylate 1,3-Piperazinedicarboxylic acid, 1-(1,1-diMethylethyl) 3-Methyl ester, (3S)- S-1-Boc-piperazine-3-carboxylic acid Methyl ester (S)-N-Boc-3-piperazinecarboxylic acid Methyl ester 1-O-tert-butyl 3-O-methyl (3S)-piperazine-1,3-dicarboxylate (S)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID METHYL EASTER (S)-tert-butyl methyl piperazine-1,3-dicarboxylate 1-(tert-butyl) 3-methyl (S)-piperazine-1,3-dicarboxylate Methyl (S)-1-Boc-piperazine-3-carboxylate 314741-39-4 Piperaizine