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4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester structure

CAS No.: 170911-92-9

Chemical Name:: 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester

Synonyms: Itraconazole Impurity 54;4-(4-Boc-piperazin-1-yl)aniline;1-BOC-4-(4'-AMINOPHENYL)PIPERAZINE;4-(4-Aminophenyl)piperazine, N1-BOC protected;4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine;4-(4-Aminophenyl)piperazine, N1-BOC protected 98%;t-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate;TERT-BUTYL 4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLATE;4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl est...

CBNumber:: CB9726019

Molecular Formula:: C15H23N3O2

Molecular Weight:: 277.36

MDL Number:: MFCD04115065

MOL File:: 170911-92-9.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:43

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4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Properties

Boiling point	441.1±40.0 °C(Predicted)
Density	1.145±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	7.69±0.10(Predicted)
form	Solid
Appearance	Brown to reddish brown Solid
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C15H23N3O2/c1-15(2,3)20-14(19)18-10-8-17(9-11-18)13-6-4-12(16)5-7-13/h4-7H,8-11,16H2,1-3H3
InChIKey	RXFHRKPNLPBDGE-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)C=C2)CC1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

HS Code

2921420090

NFPA 704

	1
2		0

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	A3499	tert-Butyl 4-(4-Aminophenyl)piperazine-1-carboxylate	170911-92-9	5G	$63	2025-07-31	Buy
TCI Chemical	A3499	tert-Butyl 4-(4-Aminophenyl)piperazine-1-carboxylate	170911-92-9	25G	$190	2025-07-31	Buy
TRC	B621140	1-Boc-4-(4-aminophenyl)piperazine	170911-92-9	5g	$330	2021-12-16	Buy
Biosynth Carbosynth	FA56975	4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester	170911-92-9	25g	$340	2021-12-16	Buy
Chem-Impex	24311	4-(4-Aminophenyl)piperazine-1-carboxylicacidtert-butylester,97%(HPLC) 97%(HPLC)	170911-92-9	5G	$156.8	2021-12-16	Buy

Product number	Packaging	Price	Buy
A3499	5G	$63	Buy
A3499	25G	$190	Buy
B621140	5g	$330	Buy
FA56975	25g	$340	Buy
24311	5G	$156.8	Buy

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Chemical Properties,Uses,Production

Uses

1-Boc-4-(4-aminophenyl)piperazine is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff.

Synthesis

4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

182618-86-6

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester

170911-92-9

The general procedure for the synthesis of tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate from tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate was as follows: first, tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate (8.2 g, 26.68 mmol) was dissolved in methanol (100 mL), followed by purging with nitrogen and depressurization. Next, 10% wet palladium carbon catalyst was added to the solution and the hydrogenation reaction was carried out under hydrogen pressure of 50 psi for 16 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth to remove the catalyst, and the filtrate was subsequently concentrated under reduced pressure to afford tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (7.4 g, 97% yield) as a dark blue oily product, which was used directly in subsequent reactions without further purification. The molecular formula of the product was C15H23N3O2, and the mass spectrometry analysis showed that the m/z was 277.9 (M + H).

References

[1] Patent: WO2006/38039, 2006, A1. Location in patent: Page/Page column 17; 30
[2] Patent: EP1215208, 2002, A2. Location in patent: Example C(101)
[3] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 52; 53
[4] Patent: WO2014/26242, 2014, A1. Location in patent: Page/Page column 77
[5] Patent: WO2014/27199, 2014, A1. Location in patent: Page/Page column 55

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Aniline 4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-Iodoaniline 1-BOC-Piperazine Hydrogen

Activated carbon Palladium Methanol

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Preparation Products

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Suppliers

Global( 160)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Zhonghan Chemical Technology Co., LTD.	+undefined15066662237	3281004549@qq.com	China	291	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29734	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Chengdu Feibo Pharm Technology Co., Ltd	+86 028-84641798 15982321820	abby@arkpharm.com	China	10922	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29801	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12233	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10242	58

Supplier	Advantage
Jinan Zhonghan Chemical Technology Co., LTD.	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Chengdu Feibo Pharm Technology Co., Ltd	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Zhengzhou Alfa Chemical Co.,Ltd	58
Hubei Ipure Biology Co., Ltd	58

View Lastest Price from 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-02	1-Piperazinecarboxylic acid, 4-(4-aMinophenyl)-, 1,1-diMethylethyl ester 170911-92-9	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2020-01-13	4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester 170911-92-9	US $6.68 / KG	1KG	97%-99%	1kg-1000kg	Career Henan Chemical Co
2020-01-13	4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester 170911-92-9	US $6.68 / KG	1KG	97%-99%	1kg-1000kg	Career Henan Chemical Co

1-Piperazinecarboxylic acid, 4-(4-aMinophenyl)-, 1,1-diMethylethyl ester
170911-92-9
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester
170911-92-9
US $6.68 / KG
97%-99%
Career Henan Chemical Co

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester
170911-92-9
US $6.68 / KG
97%-99%
Career Henan Chemical Co

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Spectrum

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester(170911-92-9)¹HNMR

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4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(2,3,4,4,4-pentadeuterio-3-hydroxybutan-2-yl)-1,2,4-triazol-3-one trans-Itraconazole VHVPQPYKVGDNFY-NZHIZTFASA-N

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TERT-BUTYL 4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLATE 4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+% 4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-4-(4'-AMINOPHENYL)PIPERAZINE 1-(4-AMINO-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER 4-(4-Boc-piperazin-1-yl)aniline 1-Piperazinecarboxylic acid, 4-(4-aminophenyl)-, 1,1-dimethylethyl ester 4-(4-Aminophenyl)piperazine, N1-BOC protected t-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate 4-(4-Aminophenyl)piperazine, N1-BOC protected 98% 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl est... Itraconazole Impurity 54 4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine 170911-92-9 179011-92-9