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ChemicalBook >> CAS DataBase List >>4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Structure
4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester structure
CAS No.
170911-92-9
Chemical Name:
4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester
Synonyms
TERT-BUTYL 4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLATE;Itraconazole Impurity 54;1-Boc-4-(4-aminophenyl)azine;4-(4-Boc-piperazin-1-yl)aniline;1-BOC-4-(4'-AMINOPHENYL)PIPERAZINE;4-(4-Aminophenyl)piperazine, N1-BOC protected;4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine;4-(4-Aminophenyl)piperazine, N1-BOC protected 98%;t-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate;4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CBNumber:
CB9726019
Molecular Formula:
C15H23N3O2
Molecular Weight:
277.36
MDL Number:
MFCD04115065
MOL File:
170911-92-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:55:21
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4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Properties

Boiling point 441.1±40.0 °C(Predicted)
Density 1.145±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 7.69±0.10(Predicted)
form Solid
Appearance Brown to reddish brown Solid
Water Solubility Slightly soluble in water.
InChI InChI=1S/C15H23N3O2/c1-15(2,3)20-14(19)18-10-8-17(9-11-18)13-6-4-12(16)5-7-13/h4-7H,8-11,16H2,1-3H3
InChIKey RXFHRKPNLPBDGE-UHFFFAOYSA-N
SMILES N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)C=C2)CC1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
HS Code  2921420090
NFPA 704
1
2 0

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester price More Price(67)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical A3499 tert-Butyl 4-(4-Aminophenyl)piperazine-1-carboxylate 170911-92-9 5G $147 2026-04-30 Buy
TCI Chemical A3499 tert-Butyl 4-(4-Aminophenyl)piperazine-1-carboxylate 170911-92-9 25G $443 2026-04-30 Buy
Usbiological 408932 1-Boc-4-(4-aminophenyl)piperazine 170911-92-9 250mg $319 2026-06-03 Buy
Usbiological 408932 1-Boc-4-(4-aminophenyl)piperazine 170911-92-9 1g $425 2026-06-03 Buy
Usbiological 261372 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Asreported 170911-92-9 500mg $333 2026-06-03 Buy
Product number Packaging Price Buy
A3499 5G $147 Buy
A3499 25G $443 Buy
408932 250mg $319 Buy
408932 1g $425 Buy
261372 500mg $333 Buy

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Chemical Properties, Uses, Production

Uses

1-Boc-4-(4-aminophenyl)piperazine is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff.

Application

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester can be used as a standard or reference for the qualitative and quantitative analysis of impurities in the synthesis of related drugs, ensuring drug purity and quality control. For example, it can be used to detect process impurities in drugs containing the 4-(4-aminophenyl)piperazine structure, and assist in the development of drug quality standards.

Synthesis

4-(4-NITROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

182618-86-6

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester

170911-92-9

The general procedure for the synthesis of tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate from tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate was as follows: first, tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate (8.2 g, 26.68 mmol) was dissolved in methanol (100 mL), followed by purging with nitrogen and depressurization. Next, 10% wet palladium carbon catalyst was added to the solution and the hydrogenation reaction was carried out under hydrogen pressure of 50 psi for 16 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth to remove the catalyst, and the filtrate was subsequently concentrated under reduced pressure to afford tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (7.4 g, 97% yield) as a dark blue oily product, which was used directly in subsequent reactions without further purification. The molecular formula of the product was C15H23N3O2, and the mass spectrometry analysis showed that the m/z was 277.9 (M + H).

References

[1] Patent: WO2006/38039, 2006, A1. Location in patent: Page/Page column 17; 30
[2] Patent: EP1215208, 2002, A2. Location in patent: Example C(101)
[3] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 52; 53
[4] Patent: WO2014/26242, 2014, A1. Location in patent: Page/Page column 77
[5] Patent: WO2014/27199, 2014, A1. Location in patent: Page/Page column 55

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Aniline 4-(4-Nitrophenyl)piperazine-1-carboxylic acid tert-butyl ester 4-Iodoaniline 1-BOC-Piperazine Hydrogen
Activated carbon Palladium Methanol

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Preparation Products

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Suppliers

Global Suppliers ( 169)
Supplier Tel Email Country ProdList Advantage
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
Supplier Advantage
Alfa Aesar 84
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Pure Chemistry Scientific Inc. 62
Accela ChemBio Co.,Ltd. 64
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai Hanhong Scientific Co.,Ltd. 64
China DongFan Chemical Co.,LTD 66

View Latest Price from 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-Piperazinecarboxylic acid, 4-(4-aMinophenyl)-, 1,1-diMethylethyl ester pictures 2021-07-02 1-Piperazinecarboxylic acid, 4-(4-aMinophenyl)-, 1,1-diMethylethyl ester
170911-92-9
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester pictures 2020-01-13 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester
170911-92-9
 $6.68 1KG 97%-99% 1kg-1000kg Career Henan Chemical Co
4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester pictures 2020-01-13 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester
170911-92-9
 $6.68 1KG 97%-99% 1kg-1000kg Career Henan Chemical Co

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester Spectrum

4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl ester(170911-92-9)1HNMR

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4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+% 4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-4-(4'-AMINOPHENYL)PIPERAZINE 1-(4-AMINO-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER 4-(4-Boc-piperazin-1-yl)aniline 1-Piperazinecarboxylic acid, 4-(4-aminophenyl)-, 1,1-dimethylethyl ester 4-(4-Aminophenyl)piperazine, N1-BOC protected t-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate 4-(4-Aminophenyl)piperazine, N1-BOC protected 98% 4-(4-Aminophenyl)piperazine-1-carboxylic acid tert-butyl est... Itraconazole Impurity 54 4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine 1-Boc-4-(4-aminophenyl)azine TERT-BUTYL 4-(4-AMINOPHENYL)PIPERAZINE-1-CARBOXYLATE 170911-92-9 179011-92-9 170911-92-0