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4-p-Aminophenyl-1-Boc-piperidine

4-p-Aminophenyl-1-Boc-piperidine structure

CAS No.: 170011-57-1

Chemical Name:: 4-p-Aminophenyl-1-Boc-piperidine

Synonyms: Ceritinib Impurity 21;4-(1-Boc-4-piperidyl)aniline;1-N-Boc-(4-aminophenyl)piperidine;4-P-AMINOPHENYL-1-BOC-PIPERIDINE;4-(1-Boc-piperidin-4-yl)-phenylami;4-(1-Boc-piperidin-4-yl)-phenylamine, 98%;1-(tert-Butoxycarbonyl)-4-(4-aminophenyl)piperidine;tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate;tert-Butyl 4-(4-aminophenyl)-1-piperidinecarboxylate;4-(4-Aminophenyl)piperidin-1-carboxylic acid tert-butyl ester

CBNumber:: CB51119429

Molecular Formula:: C16H24N2O2

Molecular Weight:: 276.37

MDL Number:: MFCD05861405

MOL File:: 170011-57-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:53:02

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4-p-Aminophenyl-1-Boc-piperidine Properties

Melting point	119 °C
Boiling point	412.7±45.0 °C(Predicted)
Density	1.100±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	4.97±0.10(Predicted)
form	powder to crystal
color	White to Yellow to Green
InChI	InChI=1S/C16H24N2O2/c1-16(2,3)20-15(19)18-10-8-13(9-11-18)12-4-6-14(17)7-5-12/h4-7,13H,8-11,17H2,1-3H3
InChIKey	YRLQFRXDWBFGMK-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC(C2=CC=C(N)C=C2)CC1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

HS Code

2933599590

NFPA 704

	0
2		0

4-p-Aminophenyl-1-Boc-piperidine price More Price(71)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B5832	tert-Butyl 4-(4-Aminophenyl)piperidine-1-carboxylate >97.0%(HPLC)	170011-57-1	200mg	$17	2026-04-30	Buy
TCI Chemical	B5832	tert-Butyl 4-(4-Aminophenyl)piperidine-1-carboxylate >97.0%(HPLC)	170011-57-1	1g	$64	2026-04-30	Buy
Usbiological	265766	1-Boc-4-(4-aminophenyl)piperidine Asreported	170011-57-1	250mg	$340	2026-06-03	Buy
Usbiological	265766	1-Boc-4-(4-aminophenyl)piperidine Asreported	170011-57-1	500mg	$468	2026-06-03	Buy
Usbiological	265766	1-Boc-4-(4-aminophenyl)piperidine Asreported	170011-57-1	1g	$751	2026-06-03	Buy

Product number	Packaging	Price	Buy
B5832	200mg	$17	Buy
B5832	1g	$64	Buy
265766	250mg	$340	Buy
265766	500mg	$468	Buy
265766	1g	$751	Buy

4-p-Aminophenyl-1-Boc-piperidine Chemical Properties, Uses, Production

Uses

1-Boc-4-(4-aminophenyl)piperidine is a useful synthetic intermediate used in the synthesis of FMS inhibitors that may be useful in treating rheumatoid arthritis and other chronic inflammatory diseases.

Synthesis

tert-butyl 4-(4-aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

873454-43-4

170011-57-1

General procedure for the synthesis of tert-butyl 4-(4-aminophenyl)piperidine-1-carboxylate from tert-butyl 4-(4-aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylate: 4-(4-aminophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (0.35 g, 1.2 mmol) (prepared in previous step) was dissolved in methanol and added to a 10% Pd/C catalyst and hydrogenated at 20 psi hydrogen pressure for 1 hour. Upon completion of the reaction, the reaction solution was filtered to remove the catalyst and the filtrate was concentrated to give 0.35 g (100% yield) of tert-butyl 4-(4-aminophenyl)piperidine-1-carboxylate as a yellow solid. Mass spectrum (ESI, m/z): the calculated value of [M+H]+ for C16H24N2O2 was 277.2 and the measured value was 277.1.

References

[1] Patent: WO2006/47277, 2006, A2. Location in patent: Page/Page column 58-59
[2] Patent: US2006/281788, 2006, A1. Location in patent: Page/Page column 55
[3] Patent: US2008/51402, 2008, A1. Location in patent: Page/Page column 41
[4] Patent: US2008/114007, 2008, A1. Location in patent: Page/Page column 90
[5] Patent: US2007/60577, 2007, A1. Location in patent: Page/Page column 53

4-p-Aminophenyl-1-Boc-piperidine Preparation Products And Raw materials

Raw materials

1(2H)-Pyridinecarboxylic acid, 3,6-dihydro-4-[4-[[(phenylmethoxy)carbonyl]amino]phenyl]-, 1,1-dimethylethyl ester tert-butyl 5,6-dihydro-4-(4-nitrophenyl)pyridine-1(2H)-carboxylate tert-butyl 4-(4-aminophenyl)-5,6-dihydropyridine-1(2H)-carboxylate 1-Boc-4-(4-nitrophenyl)Piperidine 4-(4-Nitrophenyl)pyridine

Di-tert-butyl dicarbonate Methanol Hydrogen

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Preparation Products

4-p-Aminophenyl-1-Boc-piperidine Suppliers

Global Suppliers ( 148)

Supplier	Tel	Email	Country	ProdList	Advantage
SanoChem (Chengdu) Tech. Co., Ltd.	28-87999436 02887999436	sales@sano-chem.com	China	3792	55
Shijiazhuang Hui Jiu Pharmaceutical Co., LTD	0311-0311-132 13261889099	13261889099@163.com	China	106	58
Shanghai Moss Medicine Technology Co., Ltd.	+86-188369842 +86-15618151133	188369842@qq.com	China	1965	58
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64

Supplier	Advantage
SanoChem (Chengdu) Tech. Co., Ltd.	55
Shijiazhuang Hui Jiu Pharmaceutical Co., LTD	58
Shanghai Moss Medicine Technology Co., Ltd.	58
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Jia Xing Isenchem Co.,Ltd	66
Pure Chemistry Scientific Inc.	62
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64

View Latest Price from 4-p-Aminophenyl-1-Boc-piperidine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-08-25	1-BOC-4-(4-AMINOPHENYL)PIPERIDINE 170011-57-1	$1.10-9.90	1KG	99% min	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
	2019-12-24	4-P-AMINOPHENYL-1-BOC-PIPERIDINE 170011-57-1	$1.00	1KG	99%	100KG	Career Henan Chemical Co

1-BOC-4-(4-AMINOPHENYL)PIPERIDINE
170011-57-1
$1.10-9.90
99% min
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

4-P-AMINOPHENYL-1-BOC-PIPERIDINE
170011-57-1
$1.00
99%
Career Henan Chemical Co

4-p-Aminophenyl-1-Boc-piperidine Spectrum

4-P-AMINOPHENYL-1-BOC-PIPERIDINE (170011-57-1)¹HNMR

170011-57-1 (4-p-Aminophenyl-1-Boc-piperidine) Related Search:

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tert-Butyl 4-(4-(aminomethyl)phenyl)piperidine-1-carboxylate 4-(1-Methyl-piperidin-4-yl)-aniline 4-p-Aminophenyl-1-Boc-piperidine 4-(4-Aminophenyl)-piperidine 3-(4-Amino-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

1-Boc-piperidine 1-Boc-3-(3-Aminophenyl)Piperidine 1-Boc-3-(4-Aminophenyl)Piperidine 1-Boc-4-(3-Aminophenyl)Piperidine 1-Boc-3-(2-Aminophenyl)Piperidine

1-Boc-4-(2-Aminophenyl)Piperidine

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4-P-AMINOPHENYL-1-BOC-PIPERIDINE 1-N-Boc-(4-aminophenyl)piperidine 4-(4-Aminophenyl)piperidine-1-carboxylic acid tert-butyl ester 1-Piperidinecarboxylicacid,4-(4-aMinophenyl)-,1,1-diMethylethylester 4-(1-Boc-piperidin-4-yl)-phenylamine, 98% tert-Butyl 4-(4-aminophenyl)-1-piperidinecarboxylate 4-(4-aminophenyl)-1-piperidinecarboxylic acid tert-butyl ester 1-(tert-Butoxycarbonyl)-4-(4-aminophenyl)piperidine 4-(1-Boc-piperidin-4-yl)-phenylami 4-(1-Boc-4-piperidyl)aniline tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate 4-(4-Aminophenyl)piperidin-1-carboxylic acid tert-butyl ester Ceritinib Impurity 21 170011-57-1