Naphthol as-e phosphate
- CAS No.
- 18228-17-6
- Chemical Name:
- Naphthol as-e phosphate
- Synonyms
- kg-501;KG-501 (2-naphthol-AS-E-phosphate);N-(4-chlorophenyl)-3-(phosphonooxy)naphthalene-2-carboxamide;NASEP;KD-501;KG-501, 10 mM in DMSO;Naphthol as-e phosphate;2-naphthol-AS-E-phosphate;KG-501(NaphtholAS-Ephosphate);NAPHTHOL AS-E PHOSPHATE NAPHTHOL FREE
- CBNumber:
- CB9737978
- Molecular Formula:
- C17H13ClNO5P
- Molecular Weight:
- 377.72
- MDL Number:
- MFCD00042718
- MOL File:
- 18228-17-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.567±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | DMSO: soluble |
| form | A crystalline solid |
| pka | 1.04±0.30(Predicted) |
| color | White to light yellow |
| BRN | 6664478 |
| Major Application | histology |
| InChI | 1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23) |
| InChIKey | RQAQWBFHPMSXKR-UHFFFAOYSA-N |
| SMILES | OP(O)(=O)Oc1cc2ccccc2cc1C(=O)Nc3ccc(Cl)cc3 |
| FDA UNII | H6R6B93QFC |
| UNSPSC Code | 12352204 |
| NACRES | NA.83 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| F | 8-10-21 |
| Storage Class | 11 - Combustible Solids |
Naphthol as-e phosphate price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 70485 | Naphthol AS-E phosphate for histology | 18228-17-6 | 250mg | $116 | 2026-04-30 | Buy |
| Cayman Chemical | 33602 | Naphthol AS-E Phosphate ≥98% | 18228-17-6 | 5mg | $69 | 2026-04-30 | Buy |
| Cayman Chemical | 33602 | Naphthol AS-E Phosphate ≥98% | 18228-17-6 | 10mg | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 33602 | Naphthol AS-E Phosphate ≥98% | 18228-17-6 | 25mg | $263 | 2026-04-30 | Buy |
| Biosynth | EN69791 | Naphthol AS-E phosphate, 60% | 18228-17-6 | 1000mg | $210 | 2026-06-04 | Buy |
Naphthol as-e phosphate Chemical Properties,Uses,Production
Uses
Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis th at oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP).
Biological Activity
Naphthol AS-E phosphate is a CREB inhibitor that disrupts CREB-dependent transcription (Ki=10 μM) and CREB:CBP interaction (Ki=50 μM). It also disrupts the binding of phosphorylated CREB (Ser-133) to KIX with a Ki of approximately 90 μM.
in vitro
Naphthol AS-E phosphate inhibited (or partially inhibited) the induction of cAMP-related genes by preventing CREB:CBP interaction. KG-501 inhibited neurite outgrowth, synaptogenesis and reduced MAP2+ neurons.
in vivo
Naphthol AS-E phosphate inhibited the expression of CREB, CCL2 and ERK phosphorylation, while significantly reducing cAMP levels. CREB may help to fight neuroinflammation through the cAMP/ERKadjustment pathway, thereby protecting nerves.It significantly promoted neurological function in a mouse model treated with azomethane oxide (AOM), reducing ERK phosphorylation levels and cAMP concentrations in the cortex.
target
| Target | Value | ||||
| CREB () |
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9796 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Medi-tech Bioscientific Co., Ltd. | 0519-83246372 13585352506 | China | 1838 | 58 | |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1940 | 55 |
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