- KG-501
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- $46.00
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2026-07-27
- CAS:18228-17-6
- Purity: 97.81%
- Supply Ability: 10g
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| | NAPHTHOL AS-E PHOSPHATE Basic information |
| Product Name: | NAPHTHOL AS-E PHOSPHATE | | Synonyms: | NAPHTHOL AS-E PHOSPHATE;NAPHTHOL AS-E-PHOSPHATE, FOR HISTOLOGY;NAPHTHOL AS-E PHOSPHATE NAPHTHOL FREE;N-(4-Chlorophenyl)-3-phosphonooxy-2-naphthalenecarboxamide;[3-[(4-chlorophenyl)carbamoyl]-2-naphthyl] dihydrogen phosphate;kg-501;N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE; KG-501; NASEP;NAPHTHOL AS-E PHOSPHATE;KG501;KG 501;NASEP | | CAS: | 18228-17-6 | | MF: | C17H13ClNO5P | | MW: | 377.72 | | EINECS: | 242-106-1 | | Product Categories: | Substrates;API | | Mol File: | 18228-17-6.mol |  |
| | NAPHTHOL AS-E PHOSPHATE Chemical Properties |
| density | 1.567±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | DMSO: soluble | | form | A crystalline solid | | pka | 1.04±0.30(Predicted) | | color | White to light yellow | | BRN | 6664478 | | Major Application | histology | | InChI | 1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23) | | InChIKey | RQAQWBFHPMSXKR-UHFFFAOYSA-N | | SMILES | OP(O)(=O)Oc1cc2ccccc2cc1C(=O)Nc3ccc(Cl)cc3 |
| WGK Germany | 3 | | F | 8-10-21 | | Storage Class | 11 - Combustible Solids |
| | NAPHTHOL AS-E PHOSPHATE Usage And Synthesis |
| Uses | Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis th at oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP). | | Biological Activity | Naphthol AS-E phosphate is a CREB inhibitor that disrupts CREB-dependent transcription (Ki=10 μM) and CREB:CBP interaction (Ki=50 μM). It also disrupts the binding of phosphorylated CREB (Ser-133) to KIX with a Ki of approximately 90 μM. | | in vitro | Naphthol AS-E phosphate inhibited (or partially inhibited) the induction of cAMP-related genes by preventing CREB:CBP interaction. KG-501 inhibited neurite outgrowth, synaptogenesis and reduced MAP2+ neurons. | | in vivo | Naphthol AS-E phosphate inhibited the expression of CREB, CCL2 and ERK phosphorylation, while significantly reducing cAMP levels. CREB may help to fight neuroinflammation through the cAMP/ERKadjustment pathway, thereby protecting nerves.It significantly promoted neurological function in a mouse model treated with azomethane oxide (AOM), reducing ERK phosphorylation levels and cAMP concentrations in the cortex. | | target |
| | NAPHTHOL AS-E PHOSPHATE Preparation Products And Raw materials |
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Tag:NAPHTHOL AS-E PHOSPHATE(18228-17-6)
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