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3-Chloro-4-fluoronitrobenzene

3-Chloro-4-fluoronitrobenzene structure

CAS No.: 350-30-1

Chemical Name:: 3-Chloro-4-fluoronitrobenzene

Synonyms: 2-CHLORO-1-FLUORO-4-NITROBENZENE;3-Chloro-4-fluoronit;Gefitinib Impurity 92;3-chloro-4-fluorobenzene;3-Chloro-4-fluoronitrobenzen;3-CHLORO-4-FLUORONITROANILINE;4-FLUORO-3-CHLORONITROBENZENE;3-CHLORO-4-FLUORONITROBENZENE;3-chioro-4-fluoronitrobenzene;1-CHLORO-2-FLUORO-5-NITROBENZENE

CBNumber:: CB9743847

Molecular Formula:: C6H3ClFNO2

Molecular Weight:: 175.54

MDL Number:: MFCD00007206

MOL File:: 350-30-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 06:02:28

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3-Chloro-4-fluoronitrobenzene Properties

Melting point	40-42 °C(lit.)
Boiling point	227-232°C
Density	1.61
Flash point	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	powder to crystal
color	White to Light yellow to Green
BRN	1944997
InChI	InChI=1S/C6H3ClFNO2/c7-5-3-4(9(10)11)1-2-6(5)8/h1-3H
InChIKey	DPHCXXYPSYMICK-UHFFFAOYSA-N
SMILES	C1(F)=CC=C([N+]([O-])=O)C=C1Cl
CAS DataBase Reference	350-30-1(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	8H6U84X075
NIST Chemistry Reference	3-Chloro-4-fluoronitrobenzene(350-30-1)
EPA Substance Registry System	3-Chloro-4-fluoronitrobenzene (350-30-1)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H315-H318-H335

Precautionary statements

P261-P280-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xn,Xi

Risk Statements

22-37/38-41-36/37/38-20/21/22

Safety Statements

26-39-36/37/39

RIDADR

2811

WGK Germany

RTECS

CZ0720000

Hazard Note

Irritant

HazardClass

6.1

PackingGroup

III

HS Code

29049090

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

3-Chloro-4-fluoronitrobenzene price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	233234	2-Chloro-1-fluoro-4-nitrobenzene 98%	350-30-1	25g	$187	2026-04-30	Buy
TCI Chemical	C1041	3-Chloro-4-fluoronitrobenzene >95.0%(GC)	350-30-1	25g	$17	2026-04-30	Buy
TCI Chemical	C1041	3-Chloro-4-fluoronitrobenzene >95.0%(GC)	350-30-1	250g	$82	2026-04-30	Buy
Usbiological	424954	3-Chloro-4-fluoronitrobenzene	350-30-1	1g	$319	2026-06-03	Buy
Usbiological	424954	3-Chloro-4-fluoronitrobenzene	350-30-1	5g	$410	2026-06-03	Buy

Product number	Packaging	Price	Buy
233234	25g	$187	Buy
C1041	25g	$17	Buy
C1041	250g	$82	Buy
424954	1g	$319	Buy
424954	5g	$410	Buy

3-Chloro-4-fluoronitrobenzene Chemical Properties, Uses, Production

Synthesis

In certain instances, when both chloro and nitro may act as a leaving group, a surprising selectivity of one over the other is observed, for example chloro-2,5- dinitrobenzene was converted to 4-fluoro-3-chloronitrobenzene.
3-Chloro-4-fluoronitrobenzene

Chemical Properties

white to light yellow crystal powder

Uses

2-Chloro-1-fluoro-4-nitrobenzene is an intermediate used in synthesis of benzoimidolones on Ameba resin and methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate.

Uses

2-Chloro-1-fluoro-4-nitrobenzene has been used in synthesis of:

benzoimidolones on Ameba resin
methyl 6,7,8,9-tetrahydropyrido[1,2-a]indol-10-ylacetate

Synthesis Reference(s)

The Journal of Organic Chemistry, 63, p. 8448, 1998 DOI: 10.1021/jo981557o
Synthetic Communications, 21, p. 505, 1991 DOI: 10.1080/00397919108016776

General Description

2-Chloro-1-fluoro-4-nitrobenzene undergoes reduction in the presence of Mo(CO)₆ and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) under microwave irradiation to yield a mixture of 3-chloro-4-fluoroaniline and 3-chloro-4-ethoxyaniline.

References

[1] Catalysis Today, 2012, vol. 198, # 1, p. 300 - 304
[2] Chemical Communications, 1996, # 3, p. 297 - 298
[3] Journal of Fluorine Chemistry, 2004, vol. 125, # 5, p. 701 - 704
[4] Advanced Synthesis and Catalysis, 2008, vol. 350, # 17, p. 2677 - 2682

3-Chloro-4-fluoronitrobenzene synthesis

Synthesis of 3-Chloro-4-fluoronitrobenzene from 4-Fluoronitrobenzene

3-Chloro-4-fluoronitrobenzene Preparation Products And Raw materials

Raw materials

4-Fluoronitrobenzene Fluorobenzene Dioctadecyl dimethyl ammonium chloride 3,4-Dinitrochlorobenzene 4-Chloro-3-fluoronitrobenzene

Sulfolane 2-Chlorofluorobenzene 2,4-Dinitrofluorobenzene 1,2-Dichlorobenzene 3,4-Dichloronitrobenzene

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Preparation Products

Norfloxacin 1,3-Dichloro-4-fluorobenzene 3-Chloro-4-morpholinoaniline 3,4-Difluoronitrobenzene 1-(2-Chloro-4-nitro-phenyl)-piperidine

(2-chloro-4-nitrophenyl)hydrazine

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3-Chloro-4-fluoronitrobenzene Suppliers

Global Suppliers ( 403)

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	13396369453 18678026865	sdfantai@163.com	China	904	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Liaoning Tianhua Chemical Co., Ltd.	0418-6530555 2855550		China	338	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60

Supplier	Advantage
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Liaoning Tianhua Chemical Co., Ltd.	69
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60
JinYan Chemicals(ShangHai) Co.,Ltd.	60

View Latest Price from 3-Chloro-4-fluoronitrobenzene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	3-Chloro-4-fluoronitrobenzene 350-30-1	$1.00-100.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2022-02-19	3-Chloro-4-fluoronitrobenzene 350-30-1		1KG	97.4%	100 tons	Honest Joy Holdings Limited
2021-11-02	3-Chloro-4-fluoronitrobenzene 350-30-1	$79.00	1KG	99	10T	Baoji Guokang Healthchem co.,ltd

3-Chloro-4-fluoronitrobenzene
350-30-1
$1.00-100.00
99%
Henan Fengda Chemical Co., Ltd

3-Chloro-4-fluoronitrobenzene
350-30-1
$0.00
97.4%
Honest Joy Holdings Limited

3-Chloro-4-fluoronitrobenzene
350-30-1
$79.00
99
Baoji Guokang Healthchem co.,ltd

3-Chloro-4-fluoronitrobenzene Spectrum

3-Chloro-4-fluoronitrobenzene(350-30-1)MS 3-Chloro-4-fluoronitrobenzene(350-30-1)¹HNMR 3-Chloro-4-fluoronitrobenzene(350-30-1)¹³CNMR 3-Chloro-4-fluoronitrobenzene(350-30-1)IR1 3-Chloro-4-fluoronitrobenzene(350-30-1)IR2 3-Chloro-4-fluoronitrobenzene(350-30-1)Raman

350-30-1 (3-Chloro-4-fluoronitrobenzene) Related Search:

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