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7H-Pyrrolo[2,3-d]pyrimidine

7H-Pyrrolo[2,3-d]pyrimidine structure

CAS No.: 271-70-5

Chemical Name:: 7H-Pyrrolo[2,3-d]pyrimidine

Synonyms: 7H-PYRROLO[2,3-D]PYRIMIDINE;7-Deazapurine;Pyrrolo[2,3-d]pyriMidine;3H-Pyrrolo[2,3-d]pyrimidine;DEAZAPURINE;1H-Pyrrolo[2,3-d]pyrimidine;NSC 94210;7-Deazapurine>1H-Pyrrolo[2,3-d]pyrimidi...;1H-Pyrrolo[2,3-d]pyrimidine (8CI,9CI)

CBNumber:: CB9758502

Molecular Formula:: C6H5N3

Molecular Weight:: 119.12

MDL Number:: MFCD08234403

MOL File:: 271-70-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 06:06:19

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7H-Pyrrolo[2,3-d]pyrimidine Properties

Melting point	133℃
Boiling point	297.9±23.0 °C(Predicted)
Density	1.38
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform, Dichloromethane, DMSO, Methanol
form	Powder
pka	12.79±0.20(Predicted)
color	Orange
λmax	270nm(MeOH)(lit.)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes	Xn
Risk Statements	22
WGK Germany	3
HazardClass	IRRITANT
HS Code	2933599590

7H-Pyrrolo[2,3-d]pyrimidine price More Price(66)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D4820	7-Deazapurine >98.0%(GC)(T)	271-70-5	200mg	$37	2026-04-30	Buy
TCI Chemical	D4820	7-Deazapurine >98.0%(GC)(T)	271-70-5	1g	$109	2026-04-30	Buy
Usbiological	296394	7H-Pyrrolo[2,3d]pyrimidine Asreported	271-70-5	250mg	$358	2026-06-03	Buy
Usbiological	296394	7H-Pyrrolo[2,3d]pyrimidine Asreported	271-70-5	500mg	$538	2026-06-03	Buy
Usbiological	296394	7H-Pyrrolo[2,3d]pyrimidine Asreported	271-70-5	1g	$729	2026-06-03	Buy

Product number	Packaging	Price	Buy
D4820	200mg	$37	Buy
D4820	1g	$109	Buy
296394	250mg	$358	Buy
296394	500mg	$538	Buy
296394	1g	$729	Buy

7H-Pyrrolo[2,3-d]pyrimidine Chemical Properties, Uses, Production

Uses

7H-Pyrrolo[2,3-d]pyrimidine is used as an organic synthesis or pharmaceutical intermediate. Its pyrrolo[2,3-d]pyrimidines are important parent heterocyclic compounds and are synthetic raw materials for the preparation of anti-rheumatoid arthritis and anti-tumour drugs.

Synthesis

3680-69-1

271-70-5

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine (compound 1001) (130 mg, 0.847 mmol) was used as a raw material and dissolved in 3 mL of methanol. The hydrogenation reaction was carried out by adding 10% Pd-C catalyst under hydrogen atmosphere at 1 atmosphere for 16 hours. Upon completion of the reaction, the reaction solution was concentrated to dryness to afford 7H-pyrrolo[2,3-d]pyrimidine (Compound 1002) in 100 mg yield and 98% yield. The product was characterized by 1H-NMR (CD3OD): δ 9.4 (s, 1H); 9.1 (s, 1H); 7.9 (s, 1H); 7.1 (s, 1H).

References

[1] Patent: WO2007/41130, 2007, A2. Location in patent: Page/Page column 40; Sheet 1/9
[2] Patent: US2008/9514, 2008, A1. Location in patent: Page/Page column 26-27
[3] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 21, p. 5247 - 5250
[4] European Journal of Medicinal Chemistry, 2008, vol. 43, # 6, p. 1248 - 1260
[5] Patent: WO2012/2568, 2012, A1. Location in patent: Page/Page column 37

7H-Pyrrolo[2,3-d]pyrimidine synthesis

Synthesis of 7H-Pyrrolo[2,3-d]pyrimidine from 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

7H-Pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

2-Naphthalenethiol, 1,2,3,4-tetrahydro- 4H-Pyrrolo[2,3-d]pyrimidine-4-thione,3,7-dihydro- 3-sulfanylidene-2,4,9-triazabicyclo[4.3.0]nona-7,10-dien-5-one 6-Amino-5(2,2-diethoxyethyl)-4-hydroxy-2-mercaptopyrimidine 1,2,3,4-Tetrahydro-2-naphthol

Ethyl 2,2-diethoxyethylcyanoacetate Pyrrolo[2,3-d]pyrimidin-4-ol 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Hydrogen Methanol

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Preparation Products

7H-Pyrrolo[2,3-d]pyrimidine, 7-methyl- (9CI)

7H-Pyrrolo[2,3-d]pyrimidine Suppliers

Global Suppliers ( 199)

Supplier	Tel	Email	Country	ProdList	Advantage
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.	17702719238	sales@sun-shinechem.com	China	1197	64
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16306	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
EnciPharmatech Co., Ltd	025-52714267-66 13813902930	stephen_shengll@hotmail.com	China	231	64
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5681	66
Shanghai Ennopharm Co., Ltd.	+86 (21) 6435-5022		China	4263	65

Supplier	Advantage
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Pure Chemistry Scientific Inc.	62
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.	64
Shanghai Longsheng chemical Co.,Ltd.	59
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
EnciPharmatech Co., Ltd	64
China DongFan Chemical Co.,LTD	66
Shanghai Ennopharm Co., Ltd.	65

View Latest Price from 7H-Pyrrolo[2,3-d]pyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-12-16	Baricitinib Impurity 92 271-70-5		10mg	99%+ HPLC	1000	Moxin Chemicals
2021-07-13	7H-Pyrrolo[2,3-d]pyrimidine 271-70-5	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09	7H-Pyrrolo[2,3-d]pyrimidine 271-70-5	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

Baricitinib Impurity 92
271-70-5
99%+ HPLC
Moxin Chemicals

7H-Pyrrolo[2,3-d]pyrimidine
271-70-5
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

7H-Pyrrolo[2,3-d]pyrimidine
271-70-5
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

7H-Pyrrolo[2,3-d]pyrimidine Spectrum

DEAZAPURINE(271-70-5)¹HNMR

271-70-5 (7H-Pyrrolo[2,3-d]pyrimidine) Related Search:

Pyrrolo[2,3-d]pyrimidin-4-ol 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 7H-pyrrolo[2,3-d]pyriMidine-5-carbaldehyde 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diol 2,4-Dichloro-7H-pyrrolo2,3-dpyrimidine

4-(Hydroxyamino)-4-oxobutanoic acid N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine Tofacitinib Impurity 29 N-Hydroxysuccinimide 1-Benzyl-4-methyl-piperidin-3-one hydrochloride

Benzyl chloride Malonyl chloride 4-Amino-2,6-dichloropyrimidine N-((3R,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine Tofacitinib Impurity 85

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Cyanoacetic acid-OSu 6-Amino-5(2,2-diethoxyethyl)-4-hydroxy-2-mercaptopyrimidine

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7H-PYRROLO[2,3-D]PYRIMIDINE 1H-Pyrrolo[2,3-d]pyrimidine (8CI,9CI) NSC 94210 1H-Pyrrolo[2,3-d]pyrimidi... Pyrrolo[2,3-d]pyriMidine JR-13954, 7H-Pyrrolo[2,3-d]pyrimidine, 96% 7-Deazapurine> 7H-Pyrrolo[2,3-d]pyrimidine (6CI, 7CI, ACI) 4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-ol 1H-Pyrrolo[2,3-d]pyrimidine 3H-Pyrrolo[2,3-d]pyrimidine 7-Deazapurine DEAZAPURINE 271-70-5 PYRIMIDINE Heterocycle-Pyrimidine series