ChemicalBook >> CAS DataBase List >>N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine structure

CAS No.: 477600-74-1

Chemical Name:: N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Synonyms: tofacitinib intermediate;TF-G;Tofacitinib-11;Tofacitinib N-1;Tofatinib Impurity F;Tofatinib Impurity 41;Tofacitinib Citrate Z;Tofacitinib IMpurity M;TOFACITINIB AMINE IMPURITY;Tofacitinib N-Descyanoacetyl

CBNumber:: CB2970945

Molecular Formula:: C13H19N5

Molecular Weight:: 245.32

MDL Number:: MFCD09878608

MOL File:: 477600-74-1.mol

MSDS File:: SDS

Last updated:2026-05-28 00:53:20

Request For Quotation

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Properties

Melting point	157 - 162°C
Density	1+-.0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	Aqueous Acid (Slightly), Methanol (Slightly), Water (Slightly, Heated)
form	Solid
pka	13.36±0.50(Predicted)
color	White to Off-White
InChI	InChI=1S/C13H19N5/c1-9-3-5-14-7-11(9)18(2)13-10-4-6-15-12(10)16-8-17-13/h4,6,8-9,11,14H,3,5,7H2,1-2H3,(H,15,16,17)/t9-,11+/m1/s1
InChIKey	XRIARWQZLGCQDM-KOLCDFICSA-N
SMILES	C1=NC(N(C)[C@@H]2[C@H](C)CCNC2)=C2C=CNC2=N1
FDA UNII	TD92PJW2H4

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-M296155-50MG	N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	477600-74-1	50mg	$322	2026-06-03	Buy
TRC	TRC-M296155-10MG	N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	477600-74-1	10mg	$75	2026-06-03	Buy
TRC	TRC-M296155-100MG	N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	477600-74-1	100mg	$472	2026-06-03	Buy
Biosynth	FM154245	N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	477600-74-1	0.5g	$900	2026-06-04	Buy
Biosynth	FM154245	N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	477600-74-1	0.25g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-M296155-50MG	50mg	$322	Buy
TRC-M296155-10MG	10mg	$75	Buy
TRC-M296155-100MG	100mg	$472	Buy
FM154245	0.5g	$900	Buy
FM154245	0.25g	$900	Buy

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Chemical Properties,Uses,Production

Description

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is an important pharmaceutical intermediate that is a by-product of the preparation of tofacitinib. Tofacitinib belongs to a class of Janus kinase (JAK) inhibitors used in the treatment of rheumatoid arthritis and psoriatic arthritis.

Uses

N-Methyl-N-((3S,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, is an intermediate in the synthesis of (3S,4R)-Tofacitinib (T528010), an enantiopure stereoisomer of the drug, Janus kinase 3(Jak3) inhibitor (CP-690,550) that has been found to inhibit selected members of the STE7 and STE20 subfamily of kinases.

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine synthesis

Synthesis of N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine from 1-Piperidinecarboxylic acid, 4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-, 1,1-dimethylethyl ester, (3R,4R)-

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Preparation Products And Raw materials

Raw materials

1-Piperidinecarboxylic acid, 4-methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-, 1,1-dimethylethyl ester, (3R,4R)-

Preparation Products

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Suppliers

Global( 263)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boc Chemical Co.,Ltd	021-34975603-808 18721111801	sales@bocpharma.com	China	991	64
Taizhou Yuxin Biotechnology Co., Ltd.,	+86-0576--88902229 +86-13968687450	yuxin@yuxchem.com	China	190	58
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Shanghai Feibo Chemical Technology Co., Ltd	021-58955608,2250286 15921236618	blinkzeng@gmail.com	China	522	62
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	han_yajun@dctc.daicel.com	China	7909	65
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Shanghai Coupling Pharmaceutical R&D Co.,Ltd.（Former company is Brother Chemistry）	021-50106671		China	49	58
Nanjing JinruiJiuAn Biotechnology Co., Ltd.	025-58196018 800028039	sales@fartop.net	China	2227	55

Supplier	Advantage
Shanghai Boc Chemical Co.,Ltd	64
Taizhou Yuxin Biotechnology Co., Ltd.,	58
Chembest Research Laboratories Limited	61
Adamas Reagent, Ltd.	59
Shanghai Hanhong Scientific Co.,Ltd.	64
Shanghai Feibo Chemical Technology Co., Ltd	62
Daicel Chiral Technologies (China)CO.,LTD	65
BOC Sciences	65
Shanghai Coupling Pharmaceutical R&D Co.,Ltd.（Former company is Brother Chemistry）	58
Nanjing JinruiJiuAn Biotechnology Co., Ltd.	55

View Lastest Price from N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-08	N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 477600-74-1	1kg	99%	500KG	Hangzhou ICH Biofarm Co., Ltd
2026-06-30	N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine 477600-74-1	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2026-03-12	Tofacitinib Impurity F 477600-74-1	10mg	0.98	10g	ShenZhen H&D Pharmaceutical Technology Co., LTD

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
477600-74-1
99%
Hangzhou ICH Biofarm Co., Ltd

N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine
477600-74-1
98.0%
Shaanxi Dideu New Materials Co. Ltd

Tofacitinib Impurity F
477600-74-1
$0.00
0.98
ShenZhen H&D Pharmaceutical Technology Co., LTD

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Spectrum

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine(477600-74-1)¹HNMR

477600-74-1(N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine)Related Search:

Tofacitinib N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine 3-Piperidinamine,4-methyl-1-(phenylmethyl)-,(3R,4R)-rel- methyl3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin -4-yl)amino)piperidin-1-yl)-3-oxopropanoate (3R,4S)-1-benzyl-N,4-dimethylpiperidin-3-amine

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine Tofacitinib Impurity 6 (3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile 3-((3R,4R)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanaMide 3-((3R,4R)-3-((2-chloro-7H-pyrrolo[2,3-d]pyriMidin-4-yl)(Methyl)aMino)-4-Methylpiperidin-1-yl)-3-oxopropanenitrile

3-PiperidinaMine, 1-acetyl-N,4-diMethyl-N-1H-pyrrolo[2,3-d]pyriMidin-4-yl-, (3R,4R)- (9CI) 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Tofacitinib Impurity T

1of4

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7HMethylpiperidin-3-yl)-7Hpyrrolo[ 2,3-d]pyriMidin-4-aMine (3R,4R)-N,4-diMethyl-N-{7H-pyrrolo[2,3-d]pyriMidin-4-yl}piperidin-3-aMine 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-3-piperidinyl]- N-Methyl-N-((3R,4R)-4-Methyl-piperidin-3-yl)-N-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine Tofacitinib-11 Tofacitinib N-Descyanoacetyl Tofacitinib impurity 7/N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3R,4R)-Methyl{(4-Methylpiperidin-3-yl)(7H-pyrrolo[2,3-d]pyriMidin-4-yl)}aMine 1H-Pyrrolo[2,3-d]pyriMidin-4-aMine,N-Methyl-N-[(3R,4R)-4-Methyl-3-piperidinyl]- (9CI) H-Pyrrolo[2,3-d]pyriMidin-4-aMine N-Methyl-N-[(3R,4R)-4-Methylpiperidin-3-yl]-7H-pyrrolo[2,3-d] Tofacitinib IMpurity M N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-1H-pyrrolo[2,3-d]pyrimidin-4-amine N-methyl-N-((3S,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine TF-G N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amin Tofacitinib N-Descyanoacetyl Impurity N-Methyl-N-[(3R,4R)-4-methyl-3-piperidyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine N-METHYL-N-((3R,4R)-4-METHYLPIPERIDIN-3-YL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE (CAS NO.477600-74-1) Tofacitinib Impurity-M(debenzylated) N-Methyl-N-[(3R,4R)-4-methyl-3-piperidinyl]-1H-Pyrrolo[2,3-d]pyrimidin-4-amine 1H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-methyl-N-[(3R,4R)-4-methyl-3-piperidinyl]- Azilsartan medoxomil impurity343 N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine bis(2,2,2-trifluoroacetate) N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 477600-74-1 Tofacitinib N-1 Tofatinib Impurity F N-Methyl-N-[(3R,4R)-4-methyl-3-piperidinyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine Tofatinib Impurity 41 TOFACITINIB AMINE IMPURITY N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine - [M4339] Tofacitinib Impurity M DiTrifluoroacetic acid Tofacitinib Citrate Z tofacitinib intermediate 477600-74-1 477660-74-1