6-Amino-5(2,2-diethoxyethyl)-4-hydroxy-2-mercaptopyrimidine
- CAS No.
- 7400-05-7
- Chemical Name:
- 6-Amino-5(2,2-diethoxyethyl)-4-hydroxy-2-mercaptopyrimidine
- Synonyms
- NSC 59249;Tofacitinib Impurity 157;Tofacitinib Impurity 205;6-AMINO-5-(2,2-DIETHOXYETHYL)-2-MERCAPTOPYRIMIDIN-4-OL;6-Amino-5(2,2-diethoxyethyl)-4-hydroxy-2-mercaptopyrimidine;6-amino-5-(2,2-diethoxyethyl)-2-sulfanylidene-1H-pyrimidin-4-one;6-AMino-5-(2,2-diethoxyethyl)-2,3-dihydro-2-thioxo-4(1H)-pyriMidinone;4(1H)-PyriMidinone, 6-aMino-5-(2,2-diethoxyethyl)-2,3-dihydro-2-thioxo-
- CBNumber:
- CB1348219
- Molecular Formula:
- C10H17N3O3S
- Molecular Weight:
- 259.33
- MDL Number:
- MFCD02094192
- MOL File:
- 7400-05-7.mol
- MSDS File:
- SDS
| Melting point | >300°C |
|---|---|
| Density | 1.27 |
| storage temp. | -20°C Freezer |
| solubility | DMSO, Methanol |
| pka | 8.08±0.25(Predicted) |
| form | Solid |
| color | White to Off-White |
| Stability | Sensitive to Aqueous Acid |
| CAS DataBase Reference | 7400-05-7 |
| FDA UNII | YVX56FS6AO |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| Risk Statements | 22-40 |
| Safety Statements | 36/37 |
| HS Code | 29335990 |
6-Amino-5(2,2-diethoxyethyl)-4-hydroxy-2-mercaptopyrimidine price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | A1376-99 | 6-Amino-5(2,2-diethoxyethyl)-4-hydroxy-2-mercaptopyrimidine | 2g | $552 | 2026-06-03 | Buy | |
| TRC | TRC-A604875-1G | 6-Amino-5(2,2-diethoxyethyl)-4-hydroxy-2-mercaptopyrimidine | 7400-05-7 | 1g | $79 | 2026-06-03 | Buy |
| Synthonix | A60567 | 6-Amino-5-(2,2-diethoxyethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one >98% | 7400-05-7 | 250mg | $60 | 2026-05-06 | Buy |
| Synthonix | A60567 | 6-Amino-5-(2,2-diethoxyethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one >98% | 7400-05-7 | 1g | $130 | 2026-05-06 | Buy |
| Synthonix | A60567 | 6-Amino-5-(2,2-diethoxyethyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one >98% | 7400-05-7 | 5g | $440 | 2026-05-06 | Buy |
6-Amino-5(2,2-diethoxyethyl)-4-hydroxy-2-mercaptopyrimidine Chemical Properties, Uses, Production
Chemical Properties
White Crystalline Solid
Uses
Intermediate in the production of thymidine phosphorylase inhibitors.
Synthesis
52133-67-2
17356-08-0
7400-05-7
To a freshly prepared sodium ethanolate solution [made by reacting ethanol (250 mL) with sodium metal (9.02 g, 392.55 mmol)], ethyl 2-cyano-4,4-diethoxybutyrate (45 g, 196.27 mmol) and thiourea (14.94 g, 196.27 mmol dissolved in 200 mL of ethanol) were added sequentially. The reaction mixture was heated to reflux for 3.5 hours with stirring. Upon completion of the reaction, the mixture was cooled to room temperature and stirring was continued overnight. Subsequently, the reaction was quenched with water (100 mL) and the ethanol was removed by vacuum concentration. The residue was dissolved in water (100 mL) and neutralized with dilute aqueous hydrochloric acid (3N) to pH 7 at a temperature below 10 °C. The resulting solid was collected by filtration and dried under vacuum to afford 6-amino-5-(2,2-diethoxyethyl)-2-mercapto-pyrimidin-4-ol (30.6 g, 60.19% yield) as a light yellow solid. The product was confirmed by 1HNMR, IR, MS, HPLC and elemental analysis.
References
[1] Patent: WO2010/14930, 2010, A2. Location in patent: Page/Page column 60
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 22, p. 6770 - 6789
[3] Patent: WO2006/46023, 2006, A1. Location in patent: Page/Page column 122-123
[4] Patent: WO2008/75109, 2008, A1. Location in patent: Page/Page column 112
[5] Patent: WO2006/46024, 2006, A1. Location in patent: Page/Page column 117
6-Amino-5(2,2-diethoxyethyl)-4-hydroxy-2-mercaptopyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
6-Amino-5(2,2-diethoxyethyl)-4-hydroxy-2-mercaptopyrimidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shanghai ChuangYan Chemical Technology Co., Ltd. | 021-11111111 11111111111 | 546919421@qq.com | China | 3769 | 55 |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4975 | 55 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-20242659 18930833303 | sales@changyanchem.cn | China | 4998 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Chengdu Novel Biomedical Co., Ltd. | 028-85255396 18302801538 | cdnovell@163.com | China | 2444 | 58 |
| Aikon International Limited | 025-58859352 13913916777 | dt3@aikonchem.com | China | 15490 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
7400-05-7 (6-Amino-5(2,2-diethoxyethyl)-4-hydroxy-2-mercaptopyrimidine) Related Search:
1of4
