3-Allylsalicylaldehyde
- CAS No.
- 24019-66-7
- Chemical Name:
- 3-Allylsalicylaldehyde
- Synonyms
- AKOS BBS-00003205;TIMTEC-BB SBB010096;3-Allylsalicyladehyde;3-ALLYL SALCYLALDEHYDE;3-Allylsalicylaldehyde;ASINEX-REAG BAS 02801117;Rivaroxaban Impurity 191;Salicylaldehyde, 3-allyl-;3-Allylsalicylaldehyde 97%;3-Allylsalicylaldehyde, 96.5%
- CBNumber:
- CB9767179
- Molecular Formula:
- C10H10O2
- Molecular Weight:
- 162.19
- MDL Number:
- MFCD00037364
- MOL File:
- 24019-66-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 45 °C |
|---|---|
| Boiling point | 248.88°C (rough estimate) |
| Density | 1.099 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 224 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Soluble in chloroform. |
| pka | 8.50±0.10(Predicted) |
| form | Oil |
| color | Light Yellow to Yellow |
| Sensitive | Air Sensitive |
| InChI | InChI=1S/C10H10O2/c1-2-4-8-5-3-6-9(7-11)10(8)12/h2-3,5-7,12H,1,4H2 |
| InChIKey | INLWEXRRMUMHKB-UHFFFAOYSA-N |
| SMILES | C(=O)C1=CC=CC(CC=C)=C1O |
| CAS DataBase Reference | 24019-66-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29124990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3-Allylsalicylaldehyde price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 636339 | 3-Allylsalicylaldehyde 97% | 24019-66-7 | 5g | $182 | 2026-04-30 | Buy |
| Sigma-Aldrich | 636339 | 3-Allylsalicylaldehyde 97% | 24019-66-7 | 1g | $93 | 2023-06-20 | Buy |
| TRC | TRC-A575000-5G | 3-Allyl Salicylaldehyde | 24019-66-7 | 5g | $179 | 2026-06-03 | Buy |
| TRC | TRC-A575000-500MG | 3-Allyl Salicylaldehyde | 24019-66-7 | 500mg | $64 | 2026-06-03 | Buy |
| TRC | TRC-A575000-1G | 3-Allyl Salicylaldehyde | 24019-66-7 | 1g | $91 | 2026-06-03 | Buy |
3-Allylsalicylaldehyde Chemical Properties, Uses, Production
Chemical Properties
Light Yellow Liquid
Uses
3-Allyl Salicylaldehyde is a synthetic intermediate for the sythesis of 3-aminoflavones. Flavonoids have been studied for their antiproliferative activity and in vitro cytotoxicity. Used in the prepar ation of oxazole derivatives. Used in the preparation of imidazole scaffold-based 2-substituted benzofurans for application against human tumor cell lines. Also a reagent in the synthesis of antioxida nt and antimicrobial novel chalcones.
Uses
3-Allylsalicylaldehyde is a synthetic intermediate for the synthesis of 3-aminoflavones. Flavonoids have been studied for their antiproliferative activity and in vitro cytotoxicity. It is used in the preparation of oxazole derivatives and also imidazole scaffold-based 2-substituted benzofurans for application against human tumor cell lines. It is a reagent in the synthesis of antioxidant and antimicrobial novel chalcones.
Synthesis
50-00-0
1745-81-9
24019-66-7
The general procedure for the synthesis of 3-allyl-2-hydroxybenzaldehyde from formaldehyde and 2-allylphenol was as follows: 13.5 g (0.1 mol) of 2-allylphenol and 100 mL of acetonitrile were added to a three-necked flask, and 6.5 g of paraformaldehyde, 22 g (0.39 mol) of anhydrous magnesium chloride, and 0.02 mol of triethylamine were added sequentially under stirring conditions. The reaction mixture was refluxed for 4 h. The reaction solution was poured into ice water and the pH was adjusted with aqueous hydrochloric acid to 5. It was extracted twice with ethyl acetate, the organic phases were combined and dried over anhydrous sodium sulfate. After concentration under reduced pressure, 11 g of solid product was obtained in 68% yield. Mass spectrometry analysis showed a molecular ion peak of 163 (M + 1).
References
[1] Patent: US2012/142921, 2012, A1. Location in patent: Page/Page column 13
[2] Patent: EP2468730, 2012, A1. Location in patent: Page/Page column 14
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 8, p. 1525 - 1532
[4] Organic Letters, 2012, vol. 14, # 12, p. 3226 - 3229
3-Allylsalicylaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Taizhou Chemedir Biopharm-tech. Co., Ltd | 0523-86200218 18994667082 | sale1_cmd@chemedir.com | China | 58 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
View Latest Price from 3-Allylsalicylaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-26 | 3-ALLYLSALICYLALDEHYDE
24019-66-7
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 3-ALLYLSALICYLALDEHYDE
24019-66-7
- $9.80
- ≥99%
- Career Henan Chemical Co
