ChemicalBook >> CAS DataBase List >>3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one structure

CAS No.: 86499-96-9

Chemical Name:: 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

Synonyms: 3-BroMo-2;IHT-PI BBC;3-Bromo-2,3,4,5-tetr;A-BROMOBENZOCAPROLACTAM;3-bromobenzocaprolactam;α-Bromobenzocaprolactam;α-Bromophenylcaprolactam;ALPHA-BROMOBENZO-CAPROLACTAM;3-Bromo-2,3,4,5-tetrahydro-2H-;3-BromoTetrahydrobenazepin-2-One

CBNumber:: CB9777910

Molecular Formula:: C10H10BrNO

Molecular Weight:: 240.1

MDL Number:: MFCD03085918

MOL File:: 86499-96-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 06:10:50

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3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Properties

Melting point	164 °C
Boiling point	383.2±42.0 °C(Predicted)
Density	1.492±0.06 g/cm3(Predicted)
Flash point	185.542℃
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	slightly soluble in ethanol, benzene, acetone, insoluble in water
pka	13.59±0.40(Predicted)
Appearance	Off-white to light yellow Solid
InChI	InChI=1S/C10H10BrNO/c11-8-6-5-7-3-1-2-4-9(7)12-10(8)13/h1-4,8H,5-6H2,(H,12,13)
InChIKey	JMXPGCGROVEPID-UHFFFAOYSA-N
SMILES	N1C2=CC=CC=C2CCC(Br)C1=O
CAS DataBase Reference	86499-96-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B3393	3-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one >98.0%(GC)	86499-96-9	5g	$27	2021-12-16	Buy
TCI Chemical	B3393	3-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one >98.0%(GC)	86499-96-9	25g	$81	2021-12-16	Buy
Usbiological	264164	3-Bromo-2,3,4,5-Trtrahydro-2H-1-benzazepine-2-one Asreported	86499-96-9	10g	$373	2026-06-03	Buy
Usbiological	264164	3-Bromo-2,3,4,5-Trtrahydro-2H-1-benzazepine-2-one Asreported	86499-96-9	25g	$519	2026-06-03	Buy
Usbiological	264164	3-Bromo-2,3,4,5-Trtrahydro-2H-1-benzazepine-2-one Asreported	86499-96-9	50g	$709	2026-06-03	Buy

Product number	Packaging	Price	Buy
B3393	5g	$27	Buy
B3393	25g	$81	Buy
264164	10g	$373	Buy
264164	25g	$519	Buy
264164	50g	$709	Buy

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Chemical Properties, Uses, Production

Uses

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one is an intermediate in the synthesis of Benazepril Hydrochloride. Benazepril Hydrochloride is a first-line antihypertensive drug recommended by the WHO. It is a chiral drug with excellent clinical efficacy, strong safety and tiny side effects in the international antihypertensive drugs of angiotensin converting enzyme inhibitors.

Chemical Properties

White or almost white crystalline

Preparation

The preparation of 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one is as follows:10 parts by weight of the heated melted polyphosphoric acid was added to the drying kettle, With stirring, The above 2-bromo-3,4-dihydro-N-hydroxy- (2H) -naphthalimide was added in portions at a temperature of 60 ° C, Insulation reaction for 20 hours; The reaction solution was added dropwise to 12.5 parts by weight of water to carry out hydrolysis, Still Washed to give 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one crude; 10 parts by weight of methanol and 0.1 part by weight of activated carbon were added, Heating decolorization, After filtration, the filtrate was cooled to 10 ° C for 20 hours, centrifuged, washed and dried to give 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepan-2-one. The purity of the product was 3, 10-bromo-1,3,4,5-tetrahydro-2H-1-benzazepan-2-one as high as 99.6% and the yield was as high as 98%.

Synthesis

1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one

4424-80-0

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

86499-96-9

General procedure for the synthesis of 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one from 1,3,4,5-tetrahydro-2H-1-benzazepin-2-one: 1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (1.0 g, 6.20 mmol) was dissolved in anhydrous CHCl3 (15 ml) and cooled to 0 °C ( ice-salt bath). Under argon protection, PCl5 (1.5 g, 7.20 mmol) and I2 (15 mg) were added and stirred at 0 °C for 30 min. Subsequently, Br2 (0.39 ml, 7.51 mmol) was added dropwise to the reaction solution, which was slowly warmed to room temperature and refluxed for 4.0 h under argon protection. After completion of the reaction, the mixture was poured into ice water (20 g) and the organic and aqueous phases were separated after thorough stirring. The aqueous phase was extracted with CHCl3 (25 ml), the organic phases were combined, washed with H2O (5.0 ml), dried over anhydrous MgSO4, filtered and concentrated to dryness, and dried under vacuum to give the crude product. The crude product was purified by silica gel column chromatography (Merck, 70 g) with EtOAc: hexane (1:9) as eluent to afford 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one as an off-white solid (1.137 g, 70.1% yield, melting point 170-172 °C). The structure of the product was confirmed by 1H-NMR and 13C-NMR. TLC detection: Rf 0.13 (silica gel plate, EtOAc:hexane=1:4, observed under UV light).

References

[1] Patent: US6777550, 2004, B1. Location in patent: Page column 28
[2] Patent: US4575503, 1986, A
[3] Patent: US4410520, 1983, A
[4] Patent: US4473575, 1984, A
[5] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 17, p. 3488 - 3494

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one synthesis

Synthesis of 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one from 1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Preparation Products And Raw materials

Raw materials

1(2H)-Naphthalenone, 2-bromo-3,4-dihydro-, oxime 2-Bromo-1,2,3,4-tetrahydronaphthalen-1-one 1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one Benzene Phosphorus pentachloride

1-Tetralone iodine Chloroform

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Preparation Products

L-Homophenylalanine ethyl ester S-ATBA [S-(R*,R*)]-1,3,4,5-Tetrahydro-3-[(1-phenylethyl)amino]-2H-1-benzazepin-2-one

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Suppliers

Global Suppliers ( 300)

Supplier	Tel	Email	Country	ProdList	Advantage
AstaTech(Chengdu) Biopharmaceutical Corp.	028-82666846 18080826311	sales@astatech.com.cn	China	499	58
Zhejiang Karry Pharmachem Co., Ltd.	19157666807	info@karrypharma.com	China	37	58
Shanghai Mixiu Chemical Co., Ltd.	18101936766	eileen@shmychem.com	China	349	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62

Supplier	Advantage
AstaTech(Chengdu) Biopharmaceutical Corp.	58
Zhejiang Karry Pharmachem Co., Ltd.	58
Shanghai Mixiu Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
Pure Chemistry Scientific Inc.	62

View Latest Price from 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 86499-96-9	$5.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-06-30	3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 86499-96-9		1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-06-20	3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 86499-96-9	$50.00	1kg	0.99	10000	Hebei Yanxi Chemical Co., Ltd.

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
86499-96-9
$5.00
99%
Henan Fengda Chemical Co., Ltd

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
86499-96-9
98.0%
Shaanxi Dideu New Materials Co. Ltd

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
86499-96-9
$50.00
0.99
Hebei Yanxi Chemical Co., Ltd.

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Spectrum

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one(86499-96-9)¹HNMR

86499-96-9 (3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one) Related Search:

N-Methyl-2-pyrrolidone Epiandrosterone acetate 4'-Bromoacetophenone 2-Bromoacetophenone Laurocapram

Dehydroepiandrosterone Phosphorus oxybromide Benzo[b]thien-2-ylboronic acid 2-Bromoethylamine hydrobromide Tetrahydro-4H-pyran-4-one

3-Bromoanisole Bromine 1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one 2-bromo-N-(o-tolyl)propionamide Nitrogen and hydrogen mixed gas

3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Tetrahydro

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Intermediate 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 3-bromo-1,3,4,5-tetrahydro-2H-1-benzoazepine-2-one 3-bromo-1,3,4,5-tetrahydro-1-benzazepin-2-one 3-bromo-1,3,4,5-tetrahydro-2H-1-benzoazepine-2-on A-BROMOBENZOCAPROLACTAM ALPHA-BROMOBENZO-CAPROLACTAM 3-Bromobenzocaprolactam 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 3-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 3-bromobenzocaprolactam 3-bromo-1,3,4,5-tetrahdro-2h-benzazepin-2-one 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPINE-2-ONE 3-BROMO-1,3,4,5-TETRAHYDRO-2H-L-BENZAZEPIN-2-ONE 3-BROMO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 3-BROMO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPINE-2-ONE 3-BROMO-2,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE 3-BROMO-2,3,4,5-TETRAHYDRO-2H-BENZO[B]AZEPIN-2-ONE 3-BROMO-2,3,4,5-TETRAHYDRO-2-OXO-1H-1-BENZAZEPINE 3-BROMO-2,3,4,5-TRTRAHYDRO-2H-1-BENZAZEPINE-2-ONE 5-tetrahydro-2H-benzo[b]azepin-2-one 3-BROMO-1,3,4,5-TETRAHYDRO-2H-BENZAZEPIN-2-ONE 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAEPINE-2-ONE 3-BBC: 3-BROMO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPIN-2-ONE 3-BROMO-2,3,4,5-TETRAHYDRO-2H-1-BENZAZEPINE-2-ONE 3-Bromo-2,3,4,5-tetrahydro-2H- 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPINE-2-ONE HPLC +99.0% 3-BromoTetrahydrobenazepin-2-One 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE (3-BROMO LACTAM) α-Bromobenzocaprolactam 3-bromo-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one IHT-PI BBC 3-Bromo-2,3,4,5-tetr 3-BroMo-2 5-Trtrahydro-2H-1-benzazepine-2-one 2H-1-Benzazepin-2-one, 3-broMo-1,3,4,5-tetrahydro- 3-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one > 3-Bromo-2,3,4,5-tetrahydro-2-h-1-benzacepin–2one 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one USP/EP/BP 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one (Benazepril API KSM) 3-Bromo-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one (Alpha-Bromolactum) 3-Bromo-1,3,4,5-tetrahydro-2H-1-benzoazo-2-one 3-Bromo-1,3,4,5-tetrahydro-2-h-1-benzacepin–2one 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one / Benazepril intermediate 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazazole-2-one α-Bromophenylcaprolactam 3-bromo-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazazepine Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 86499-96-9 65-71-6 68499-96-9 96499-96-9 C10H10BrNO C10H10NOBr pharmacetical 86499-96-9 john's