2-Hydrazinobenzothiazole
- CAS No.
- 615-21-4
- Chemical Name:
- 2-Hydrazinobenzothiazole
- Synonyms
- 2-Hydrazinylbenzo[d]thiazole;2 HzBTZ;2-HzBTZ;IDO1-IN-1;AKOS B003351;AKOS BC-3071;IDO1 inhibitor 1;IDO1-inhibitor-1;AKOS BBS-00007373;IFLAB-BB F0896-0067
- CBNumber:
- CB9782736
- Molecular Formula:
- C7H7N3S
- Molecular Weight:
- 165.22
- MDL Number:
- MFCD00041849
- MOL File:
- 615-21-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 198-202 °C (lit.) |
|---|---|
| Boiling point | 352.4±25.0 °C(Predicted) |
| Density | 1.2404 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | Solubility in hot methanol almost transparent. |
| form | powder to crystal |
| pka | 2.81±0.20(Predicted) |
| color | White to Light yellow to Light orange |
| InChI | InChI=1S/C7H7N3S/c8-10-7-9-5-3-1-2-4-6(5)11-7/h1-4H,8H2,(H,9,10) |
| InChIKey | JYSUYJCLUODSLN-UHFFFAOYSA-N |
| SMILES | S1C2=CC=CC=C2N=C1NN |
| CAS DataBase Reference | 615-21-4(CAS DataBase Reference) |
| FDA UNII | JS4DO3CU7W |
| EPA Substance Registry System | 2(3H)-Benzothiazolone, hydrazone (615-21-4) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DL4725000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29342000 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 Skin Irrit. 2 |
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| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2-Hydrazinobenzothiazole price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 642436 | 2-Hydrazinobenzothiazole 97% | 615-21-4 | 5g | $119 | 2026-04-30 | Buy |
| Sigma-Aldrich | 642436 | 2-Hydrazinobenzothiazole 97% | 615-21-4 | 25g | $298 | 2023-06-20 | Buy |
| TCI Chemical | H0177 | 2-Hydrazinobenzothiazole >99.0%(T) | 615-21-4 | 5g | $45 | 2026-04-30 | Buy |
| TCI Chemical | H0177 | 2-Hydrazinobenzothiazole >99.0%(T) | 615-21-4 | 25g | $121 | 2026-04-30 | Buy |
| Apolloscientific | OR9046 | 2-Hydrazino-1,3-benzothiazole >99% | 615-21-4 | 1g | $21 | 2026-06-04 | Buy |
2-Hydrazinobenzothiazole Chemical Properties, Uses, Production
Chemical Properties
slightly yellow to beige-green crystalline powder
Uses
It is employed in the spectrophotometric analysis determination of methenamine and its salts. It is also used in the detection and repair mechanism of Etheno-DNA adducts.
Synthesis
136-95-8
615-21-4
General procedure for the synthesis of 2-hydrazinobenzothiazole from 2-aminobenzothiazole: Hydrazine hydrate (1 equiv.) was dissolved in ethylene glycol at 5 °C. Under stirring, concentrated hydrochloric acid (2 mL) was added slowly and dropwise, followed by 2-aminobenzothiazole (1 eq.). The reaction mixture was heated to reflux for 2-3 hours, after which it was cooled to room temperature. Upon completion of the reaction, the solid product formed was collected by filtration, washed with water and purified by recrystallization from ethanol to afford the target compound 2-hydrazinobenzo[d]thiazole (32). The product was white crystals in 90% yield with a melting point ranging from 200 °C to 202 °C. 1H NMR (DMSO-d6, 400 MHz) data were as follows: δ 4.84 (2H, s), 6.85-7.65 (4H, m), 8.62 (1H, s). ESI-MS (m/z) analysis showed the molecular ion peak as 166 (MH+).
References
[1] Helvetica Chimica Acta, 1980, vol. 63, # 3, p. 682 - 692
[2] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 418 - 428
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 14, p. 4022 - 4025
[4] Medicinal Chemistry Research, 2012, vol. 21, # 9, p. 2428 - 2442
[5] Journal of Molecular Structure, 2014, vol. 1060, # 1, p. 215 - 222
2-Hydrazinobenzothiazole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Shanyang Pharmaceutical Technology Co., | 0512-63268889 18506119477 | 82169840@qq.com | China | 624 | 58 |
| Tianjing Geneston Bio-tech Co.,Ltd. | 022-60131465 18920720807 | zishan_1986@163.com | China | 744 | 58 |
| Hangzhou Verychem Science And Technology Co.Ltd | +86-86-57188162785 +8613606544505 | lucy@verychem.com | China | 1220 | 58 |
| SuZhou Nahsor PharmTec Co.，Ltd | 13482028355 | 46630809@qq.com | China | 129 | 58 |
| Jiangxi Jingyang Chemical Products Co., LTD | 0798-15170312128 15170312128 | 1436027029@qq.com | China | 16 | 58 |
| Hunan chemfish Scientific co.,ltd | 85567275 18932438858 | sales06@chemfish.com | China | 5003 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Latest Price from 2-Hydrazinobenzothiazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 2-Hydrazinobenzothiazole
615-21-4
|
$1.10-9.90 | 1KG | 99%min | 100KG | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-08-08 | IDO1-IN-1
615-21-4
|
$29.00 | 99.61% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-04 | 2-Hydrazinobenzothiazole
615-21-4
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 2-Hydrazinobenzothiazole
615-21-4
- $1.10-9.90
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- IDO1-IN-1
615-21-4
- $29.00
- 99.61%
- TargetMol Chemicals Inc.
-
- 2-Hydrazinobenzothiazole
615-21-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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