(3-Bromo-pyridin-2-yl)-methyl-amine
- CAS No.
- 214977-38-5
- Chemical Name:
- (3-Bromo-pyridin-2-yl)-methyl-amine
- Synonyms
- 3-BROMO-2-METHYLAMINOPYRIDINE;3-bromo-N-methyl-2-pyridinamine;3-bromo-N-methylpyridin-2-amine;2-Pyridinamine, 3-bromo-N-methyl-;(3-Bromo-pyridin-2-yl)-methyl-amine
- CBNumber:
- CB9795280
- Molecular Formula:
- C6H7BrN2
- Molecular Weight:
- 187.04
- MDL Number:
- MFCD07374349
- MOL File:
- 214977-38-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H320-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| HS Code | 2933399990 |
(3-Bromo-pyridin-2-yl)-methyl-amine price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR901758 | 3-bromo-N-methylpyridin-2-amine 98% | 214977-38-5 | 1g | $77 | 2026-06-04 | Buy |
| Apolloscientific | OR901758 | 3-bromo-N-methylpyridin-2-amine 98% | 214977-38-5 | 5g | $332 | 2026-06-04 | Buy |
| Apolloscientific | OR901758 | 3-bromo-N-methylpyridin-2-amine 98% | 214977-38-5 | 25g | $1647 | 2026-06-04 | Buy |
| Activate Scientific | AS146857 | 3-Bromo-N-methylpyridin-2-amine 98% | 214977-38-5 | 1g | $84 | 2026-06-04 | Buy |
| Activate Scientific | AS146857 | 3-Bromo-N-methylpyridin-2-amine 98% | 214977-38-5 | 5g | $368 | 2026-06-04 | Buy |
(3-Bromo-pyridin-2-yl)-methyl-amine Chemical Properties, Uses, Production
Synthesis
13534-99-1
74-88-4
214977-38-5
A tetrahydrofuran (THF, 0.4 M) suspension of sodium hydride (NaH, 110 mol%) was placed in a reaction vessel at 0 °C and a THF (0.5 M) solution of 2-amino-3-bromopyridine (100 mol%) was slowly added. The reaction mixture was stirred at 0 °C for 5 min, followed by warming to 23 °C and continued stirring for 5 min. The reaction vessel was transferred to a preheated oil bath and stirred at 40 °C for 1 hour. Upon completion of the reaction, the mixture was cooled to 0 °C and iodomethane (MeI, 110 mol%) was added. The reaction was maintained at 0 °C for 5 min, then warmed to 23 °C and stirred for another 5 min. Subsequently, the reaction mixture was heated to 60 °C for 12 hours. At the end of the reaction, the reaction was cooled to 23 °C, quenched with water and extracted with ethyl acetate (EtOAc). The organic layers were combined, dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure. Purification by fast column chromatography (eluent: hexane/ethyl acetate, 1:1) afforded 3-bromo-N-methylpyridin-2-amine (S6) as an orange oil in 78% yield (760.0 mg, 4.50 mmol).1H NMR (400 MHz, CDCl3) δ 8.09 (dd, J = 4.9, 1.6 Hz, 1H), 7.59 ( dd, J = 7.6, 1.6 Hz, 1H), 6.44 (dd, J = 7.6, 4.9 Hz, 1H), 3.03 (d, J = 4.9 Hz, 3H). 13C NMR (100 MHz, CDCl3) δ 155.0, 146.7, 139.3, 113.0, 105.6, 28.7. The obtained data are in agreement with the literature reports.
References
[1] Synthesis, 2007, # 24, p. 3868 - 3876
[2] European Journal of Organic Chemistry, 2017, vol. 2017, # 11, p. 1465 - 1474
[3] Tetrahedron, 2015, vol. 71, # 35, p. 5776 - 5780
(3-Bromo-pyridin-2-yl)-methyl-amine Preparation Products And Raw materials
Raw materials
Preparation Products
(3-Bromo-pyridin-2-yl)-methyl-amine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
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| Zhengzhou HSH Science & Technology Co., Ltd. | 0371-55932928 18937192232; | 1282296214@qq.com | China | 497 | 55 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9780 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Zhengzhou Huiju Chemical Co., Ltd. | 0371-55900031 18137872243 | 3927209986@qq.com | China | 9999 | 55 |
| Suzhou Nuoouman Biological Technology Co., Ltd. | 15026866316 | 180642609@qq.com | China | 4966 | 58 |
| SHANGHAI FDC-CHEMICAL CO.,LTD | 021-61469567 13774476675 | sales@fdc-chemical.com | China | 10000 | 58 |
| Shanghai Benso Pharmaceutical Technology Co., Ltd. | 13023173052 | 248775804@qq.com | China | 4917 | 58 |
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