Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-

2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-

2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]- Structure
2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]- structure
CAS No.
2443816-45-1
Chemical Name:
2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-
Synonyms
ULK-101, 10 mM in DMSO;Unc-51 like kinase,ULK-101,ULK,ULK 101,Inhibitor,ULK101,inhibit;(S)-N-(1-cyclopropyl-2,2,2-trifluoroethyl)-4-(6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide;2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-
CBNumber:
CB98097443
Molecular Formula:
C22H16F4N4OS
Molecular Weight:
460.45
MDL Number:
MFCD31813791
MOL File:
2443816-45-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-23 14:48:42
Request For Quotation

2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]- Properties

storage temp. -10 to -25°C
solubility DMSO: 2mg/mL, clear
form Solid
color Light yellow to yellow
InChI 1S/C22H16F4N4OS/c23-16-5-3-12(4-6-16)15-8-27-20-17(9-28-30(20)10-15)14-7-18(32-11-14)21(31)29-19(13-1-2-13)22(24,25)26/h3-11,13,19H,1-2H2,(H,29,31)/t19-/m0/s1
InChIKey PFZRXJIYAFANHP-IBGZPJMESA-N
SMILES FC(F)(F)[C@H](C1CC1)NC(C2=CC(C3=C4N(N=C3)C=C(C5=CC=C(C=C5)F)C=N4)=CS2)=O
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3480 ULK-101 ≥98% (HPLC) 2443816-45-1 5MG $125 2026-04-30 Buy
Sigma-Aldrich SML3480 ULK-101 ≥98% (HPLC) 2443816-45-1 25MG $469 2026-04-30 Buy
Cayman Chemical 40403 ULK-101 ≥95% 2443816-45-1 1mg $31 2026-04-30 Buy
Cayman Chemical 40403 ULK-101 ≥95% 2443816-45-1 5mg $124 2026-04-30 Buy
Cayman Chemical 40403 ULK-101 ≥95% 2443816-45-1 10mg $216 2026-04-30 Buy
Product number Packaging Price Buy
SML3480 5MG $125 Buy
SML3480 25MG $469 Buy
40403 1mg $31 Buy
40403 5mg $124 Buy
40403 10mg $216 Buy

2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]- Chemical Properties, Uses, Production

Uses

ULK-101 is a potent and selective ULK1 inhibitor, with IC50 values of 1.6 nM and 30 nM for ULK1 and ULK2, respectively. ULK-101 suppresses autophagy and sensitizes cancer cells to nutrient stress[1].

Biological Activity

ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively.

in vitro

ULK-101 inhibited the induction of autophagy and autophagic flux under different stimuli. ULK-101 sensitizes KRAS-mutated lung cancer cells to nutrient stress.

target

TargetValue
ULK1
(Cell-free assay)		 8.3 nM
ULK2
(Cell-free assay)		 30 nM

IC 50

ULK1: 1.6 nM (IC50); ULK2: 30 nM (IC50)

References

[1] Martin KR, et al. A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct 26;8:74-84. DOI:10.1016/j.isci.2018.09.012

2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]- Suppliers

Global Suppliers ( 48)
Supplier Tel Email Country ProdList Advantage
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2969 58
Beijing Solarbio Science & Tecnology Co., Ltd. 17801761073 18101056239 3193328036@qq.com China 28150 68
Chuzhou KeMail Chemical Technology Co., Ltd 0550-5196001 15000891977 wj520wjxby@126.com China 1940 55
Shanghai Jizhi Biochemical Technology Co. Ltd. 021-4009004166/18616739031 18616739031 3007523370@qq.com China 40000 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 sales@sarms4muscle.com China 10378 58
Wuxi Donghe Pharmaceutical Technology Co., Ltd. 63313187 15358055255 63313187@qq.com China 1982 58
Supplier Advantage
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Shanghai Rechem science Co., Ltd. 58
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Chuzhou KeMail Chemical Technology Co., Ltd 55
Shanghai Jizhi Biochemical Technology Co. Ltd. 58
TargetMol Chemicals Inc. 58
Zhejiang J&C Biological Technology Co.,Limited 58
Wuxi Donghe Pharmaceutical Technology Co., Ltd. 58

View Latest Price from 2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]- pictures 2026-07-24 2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-
2443816-45-1
 1KG 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
ULK-101 pictures 2026-07-17 ULK-101
2443816-45-1
 $107.00-396.00 99.94% 10g TargetMol Chemicals Inc.
  • ULK-101 pictures
  • ULK-101
    2443816-45-1
  • $107.00-396.00
  • 99.94%
  • TargetMol Chemicals Inc.

2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]- Spectrum

2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-(2443816-45-1)1HNMR

2443816-45-1 (2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-) Related Search:

ULK-100 2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]- XL-388 OSI-027 SiroliMus-D3/ RapaMycin-D3
BML-275

1of2

2-Thiophenecarboxamide, N-[(1S)-1-cyclopropyl-2,2,2-trifluoroethyl]-4-[6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]- (S)-N-(1-cyclopropyl-2,2,2-trifluoroethyl)-4-(6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide Unc-51 like kinase,ULK-101,ULK,ULK 101,Inhibitor,ULK101,inhibit ULK-101, 10 mM in DMSO 2443816-45-1 C22H16F4N4OS api