ChemicalBook >> CAS DataBase List >>3-Thiazolidinecarboxamide, N-(3,4-dichlorophenyl)-2-[(4-fluorophenyl)imino]-5-methyl-

3-Thiazolidinecarboxamide, N-(3,4-dichlorophenyl)-2-[(4-fluorophenyl)imino]-5-methyl-

3-Thiazolidinecarboxamide, N-(3,4-dichlorophenyl)-2-[(4-fluorophenyl)imino]-5-methyl- structure

CAS No.: 2411853-34-2

Chemical Name:: 3-Thiazolidinecarboxamide, N-(3,4-dichlorophenyl)-2-[(4-fluorophenyl)imino]-5-methyl-

Synonyms: JR-AB2-011 ，E1151;JR-AB2-011, 10 mM in DMSO;JRAB2011,JR-AB-2-011,JR AB2 011;N-(3,4-Dichlorophenyl)-2-((4-fluorophenyl)imino)-5-methylthiazolidine-3-carboxamide;3-Thiazolidinecarboxamide, N-(3,4-dichlorophenyl)-2-[(4-fluorophenyl)imino]-5-methyl-

CBNumber:: CB98358531

Molecular Formula:: C17H14Cl2FN3OS

Molecular Weight:: 398.28

MDL Number:

MOL File:: 2411853-34-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

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3-Thiazolidinecarboxamide, N-(3,4-dichlorophenyl)-2-[(4-fluorophenyl)imino]-5-methyl- Properties

Density	1.45±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Ethanol:3.0(Max Conc. mg/mL);7.53(Max Conc. mM)
form	Solid
pka	11.58±0.70(Predicted)
color	White to off-white
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

3-Thiazolidinecarboxamide, N-(3,4-dichlorophenyl)-2-[(4-fluorophenyl)imino]-5-methyl- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML3644	JR-AB2-011 ≥98% (HPLC)	2411853-34-2	5MG	$274	2026-04-30	Buy
Sigma-Aldrich	SML3644	JR-AB2-011 ≥98% (HPLC)	2411853-34-2	25MG	$1110	2026-04-30	Buy
Biosynth	LWD85334	Jr-ab2-011	2411853-34-2	25mg	$1164.25	2026-06-04	Buy
Biosynth	LWD85334	Jr-ab2-011	2411853-34-2	50mg	$1620	2026-06-04	Buy
ChemScene	CS-0081286	JR-AB2-011 98.15%	2411853-34-2	5mg	$282	2026-06-04	Buy

Product number	Packaging	Price	Buy
SML3644	5MG	$274	Buy
SML3644	25MG	$1110	Buy
LWD85334	25mg	$1164.25	Buy
LWD85334	50mg	$1620	Buy
CS-0081286	5mg	$282	Buy

3-Thiazolidinecarboxamide, N-(3,4-dichlorophenyl)-2-[(4-fluorophenyl)imino]-5-methyl- Chemical Properties, Uses, Production

Uses

JR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM. JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 μM)[1].JR-AB2-011 decreases the phosphorylation level of Akt, decreases MMP2 activity, thereby reducing the ability of tumor cells to migrate and invade. JR-AB2-011 also induces non-apoptotic cell death[2].

Biological Activity

JR-AB2-011 is a selective mTORC2 inhibitor th at blocks the interaction of Rictor and mTOR (IC50 = 0.31 μM) without affecing mTORC1 activity or assembly. JR-AB2-011 exhibits anti-glioblastoma (GBM) activity in vitro (proliferation IC50 = 0.31 μM post 72h treatment, 36.3% apoptosis post 48h 1 μM treatment in LN229 cultures) and in vivo (4 or 20 mg/kg/d i.p. to LN229 xenografted mice).

in vivo

Mice were subcutaneously implanted with tumor cells and when tumors were palpable (~200 mm3), mice were randomized into treatment groups receiving vehicle, JR-AB2-011 (4 mg/kg/d) and JR-AB2-011 (20 mg/kg/d). As shown in Fig 6A, mice receiving JR-AB2-011 at either dosing regimen displayed marked inhibition of tumor growth rate (JR-AB2-011 at 4 mg/kg/d; 74% inhibition at end of dosing period; tumor growth delay 10.0 days; JR-AB2-011 at 20 mg/kg/d; 80% inhibition at end of dosing period; tumor growth delay 12.0 days) as compared to mice receiving vehicle alone. Consistent with the effects on xenograft growth, overall survival of mice at either JR-AB2-011 dosing regimen was significantly extended relative to vehicle treated mice. _x000D_ _x000D_ Reference: PLoS One. 2017 Apr 28;12(4):e0176599. https://pubmed.ncbi.nlm.nih.gov/28453552/

target

JR-AB2-011 is a selective mTORC2 inhibitor with an IC50 value of 0.36 μM. JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association (Ki: 0.19 μM).

IC 50

mTORC2: 0.36 μM (IC₅₀)

References

[1] Zhang A, et al. CCL17 exerts neuroprotection through activation of CCR4/mTORC2 axis in microglia after subarachnoid haemorrhage in rats. Stroke Vasc Neurol. 2022 Jul 26;8(1):4–16. DOI:10.1136/svn-2022-001659
[2] Guenzle J, et al. Pharmacological Inhibition of mTORC2 Reduces Migration and Metastasis in Melanoma. Int J Mol Sci. 2020 Dec 22;22(1):30
[3] Wu M, et al Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization. Pharmacol Res. 2021 Oct ; 172:105796 DOI:10.1016/j.phrs.2021.105796

3-Thiazolidinecarboxamide, N-(3,4-dichlorophenyl)-2-[(4-fluorophenyl)imino]-5-methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

3-Thiazolidinecarboxamide, N-(3,4-dichlorophenyl)-2-[(4-fluorophenyl)imino]-5-methyl- Suppliers

Global Suppliers ( 31)

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4773	55
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Shanghai Chaolan Chemical Technology Center	QQ：65489617 13301690235	Sales@ATKchemical.com	China	9729	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
JinOu Biomedical (Nanjing) Co., Ltd.	13000000000	jinoupharma@163.com	China	11706	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	59929	58
InvivoChem	13549236410	sales@invivochem.cn	China	6745	58
Beijing Biocreative Technology Co., Ltd.	15522676233	3007606172@qq.com	China	1246	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24951	58

Supplier	Advantage
BOC Sciences	65
Guangzhou Isun Pharmaceutical Co., Ltd	55
Shanghai YuanYe Biotechnology Co., Ltd.	60
Shanghai Chaolan Chemical Technology Center	58
TargetMol Chemicals Inc.	58
JinOu Biomedical (Nanjing) Co., Ltd.	58
Bide Pharmatech Ltd.	58
InvivoChem	58
Beijing Biocreative Technology Co., Ltd.	58
TargetMol Chemicals Inc.	58

View Latest Price from 3-Thiazolidinecarboxamide, N-(3,4-dichlorophenyl)-2-[(4-fluorophenyl)imino]-5-methyl- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	JR-AB2-011 2411853-34-2	$87.00-363.00		99.41%	10g	TargetMol Chemicals Inc.
	2026-07-27	JR-AB2-011 2411853-34-2	$87.00-363.00		99.41%	10g	TargetMol Chemicals Inc.

JR-AB2-011
2411853-34-2
$87.00-363.00
99.41%
TargetMol Chemicals Inc.

JR-AB2-011
2411853-34-2
$87.00-363.00
99.41%
TargetMol Chemicals Inc.

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3-Thiazolidinecarboxamide, N-(3,4-dichlorophenyl)-2-[(4-fluorophenyl)imino]-5-methyl- JRAB2011,JR-AB-2-011,JR AB2 011 JR-AB2-011, 10 mM in DMSO N-(3,4-Dichlorophenyl)-2-((4-fluorophenyl)imino)-5-methylthiazolidine-3-carboxamide JR-AB2-011 ，E1151 2411853-34-2