ChemicalBook >> CAS DataBase List >>1,2-Cyclopentanediol, 3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydro-8-isoquinolinyl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2S,3S,5R)-

1,2-Cyclopentanediol, 3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydro-8-isoquinolinyl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2S,3S,5R)-

1,2-Cyclopentanediol, 3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydro-8-isoquinolinyl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2S,3S,5R)- structure

CAS No.: 2159123-14-3

Chemical Name:: 1,2-Cyclopentanediol, 3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydro-8-isoquinolinyl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2S,3S,5R)-

Synonyms: PRMT5-IN-3;PF-06939999/PRMT5-IN-3;(1S,2S,3S,5R)-3-([6-(difluoromelhyl)-5-fluoro-1,2l3,4-tetrahydroisoquinolin-8-yl]oxy}-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol;1,2-Cyclopentanediol, 3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydro-8-isoquinolinyl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2S,3S,5R)-

CBNumber:: CB98381920

Molecular Formula:: C22H23F3N4O3

Molecular Weight:: 448.44

MDL Number:

MOL File:: 2159123-14-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:44

Request For Quotation

1,2-Cyclopentanediol, 3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydro-8-isoquinolinyl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2S,3S,5R)- Properties

Boiling point	572.5±50.0 °C(Predicted)
Density	1.61±0.1 g/cm3(Predicted)
pka	12.86±0.70(Predicted)
form	Solid
color	White to off-white
FDA UNII	JY9FEZ3ZDX

1,2-Cyclopentanediol, 3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydro-8-isoquinolinyl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2S,3S,5R)- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	JLD12314	PRMT5-IN-3	2159123-14-3	25mg	$1029.75	2026-06-04	Buy
Biosynth	JLD12314	PRMT5-IN-3	2159123-14-3	50mg	$1433	2026-06-04	Buy
Biosynth	JLD12314	PRMT5-IN-3	2159123-14-3	100mg	$2293	2026-06-04	Buy
ChemScene	CS-0135959	PF-06939999 99.84%	2159123-14-3	1mg	$249	2026-06-04	Buy
ChemScene	CS-0135959	PF-06939999 99.84%	2159123-14-3	5mg	$598	2026-06-04	Buy

Product number	Packaging	Price	Buy
JLD12314	25mg	$1029.75	Buy
JLD12314	50mg	$1433	Buy
JLD12314	100mg	$2293	Buy
CS-0135959	1mg	$249	Buy
CS-0135959	5mg	$598	Buy

1,2-Cyclopentanediol, 3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydro-8-isoquinolinyl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2S,3S,5R)- Chemical Properties,Uses,Production

Uses

PF-06939999 (PRMT5-IN-3) is a SAM-competitive, orally active PRMT5 inhibitor that inhibits the expression of SDMA protein (IC50 in A427 is 1.1 nM), exhibits synthetic lethality to tumor cells but produce few side effects combined with DNA damaging agents[1][2].

in vivo

PF-06939999 (3-30 mg/kg, po, once a day for 36-44 days) exhibits antitumor effect in mouse A427 or NCI-H441 xenograft models^[2].

Animal Model:	Mouse A427 or NCI-H441 xenograft models^[2]
Dosage:	3-30 mg/kg
Administration:	po, once a day for 36-44 days
Result:	Inhibited tumor growth.

IC 50

PRMT5

References

[1] Adli M. Combinatorial drug treatment of cancer. WO2020198601A1.
[2] Jensen-Pergakes K, et al., SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol Cancer Ther. 2022 Jan;21(1):3-15. DOI:10.1158/1535-7163.MCT-21-0620

1,2-Cyclopentanediol, 3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydro-8-isoquinolinyl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2S,3S,5R)- Preparation Products And Raw materials

Raw materials

Preparation Products

1,2-Cyclopentanediol, 3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydro-8-isoquinolinyl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2S,3S,5R)- Suppliers

Global( 6)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Kaixin Chemical (Hong Kong) Limited	010-88886666-01 13112345678	loyson@qq.com	China	589	55
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24951	58
Shanghai Tachizaki Biomedical Research Center	18014399201	sales@chemlab-tachizaki.com	China	2936	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	cindy.huang@synzest.com	China	11975	58

Supplier	Advantage
BOC Sciences	65
Kaixin Chemical (Hong Kong) Limited	55
TargetMol Chemicals Inc.	58
Shanghai Tachizaki Biomedical Research Center	58
Nanjing Shizhou Biology Technology Co.,Ltd	58

2159123-14-3(1,2-Cyclopentanediol, 3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydro-8-isoquinolinyl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2S,3S,5R)-)Related Search:

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1,2-Cyclopentanediol, 3-[[6-(difluoromethyl)-5-fluoro-1,2,3,4-tetrahydro-8-isoquinolinyl]oxy]-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-, (1S,2S,3S,5R)- (1S,2S,3S,5R)-3-([6-(difluoromelhyl)-5-fluoro-1,2l3,4-tetrahydroisoquinolin-8-yl]oxy}-5-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol PF-06939999/PRMT5-IN-3 PRMT5-IN-3 2159123-14-3