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4-Bromo-2-methylquinoline

4-Bromo-2-methylquinoline Structure
4-Bromo-2-methylquinoline structure
CAS No.
50488-44-3
Chemical Name:
4-Bromo-2-methylquinoline
Synonyms
4-Bromoquinaldine;2-Methyl-4-broMoquinoline;4-Bromo-2-methylquinoline;Quinoline, 4-bromo-2-methyl-;4-Bromo-2-methylquinoline 97%min;4-BROMO-2-METHYLQUINOLINE ISO 9001：2015 REACH
CBNumber:
CB9846711
Molecular Formula:
C10H8BrN
Molecular Weight:
222.08
MDL Number:
MFCD02278398
MOL File:
50488-44-3.mol
MSDS File:
SDS
Last updated:2026-09-12 18:56:37
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4-Bromo-2-methylquinoline Properties

Boiling point 88-90℃ (1 Torr)
Density 1.488±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 4.21±0.50(Predicted)
Appearance Yellow to brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280-P302+P352-P362+P364
HS Code  2933499090

4-Bromo-2-methylquinoline price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR931757 4-Bromo-2-methylquinoline 99% 50488-44-3 1g $52 2026-06-04 Buy
Apolloscientific OR931757 4-Bromo-2-methylquinoline 99% 50488-44-3 5g $249 2026-06-04 Buy
Apolloscientific OR931757 4-Bromo-2-methylquinoline 99% 50488-44-3 25g $1042 2026-06-04 Buy
Activate Scientific AS40717 4-Bromo-2-methylquinoline 97% 50488-44-3 1g $82 2026-06-04 Buy
Activate Scientific AS40717 4-Bromo-2-methylquinoline 97% 50488-44-3 5g $315 2026-06-04 Buy
Product number Packaging Price Buy
OR931757 1g $52 Buy
OR931757 5g $249 Buy
OR931757 25g $1042 Buy
AS40717 1g $82 Buy
AS40717 5g $315 Buy

4-Bromo-2-methylquinoline Chemical Properties, Uses, Production

Uses

4-Bromo-2-methylquinoline belongs to the quinoline class of organic compounds and can be used as a pharmaceutical intermediate. Literature reports that it can be used to prepare a class of carboxylic acid-substituted (hetero)aromatic ring derivatives with dual inhibitory activity against xanthine oxidase and URAT1, such as 4-(2-cyanoquinoline-4-yl)-2-hydroxybenzoic acid.

Synthesis

4-Hydroxy-2-methylquinoline

607-67-0

4-BROMO-2-METHYLQUINOLINE

50488-44-3

(4a) 4-Hydroxy-2-methylquinoline (17.4 g, 109 mmol) and phosphorus oxyfluoride (47.1 g, 164 mmol) were added in a round bottom flask. The reaction mixture was heated to 130 °C and maintained for several hours. After completion of the reaction, it was cooled to room temperature and the residue was partitioned between saturated Na2CO3 solution and ethyl acetate. The organic layer was separated and the aqueous layer was extracted with ethyl acetate (5 × 300 mL). The organic layers were combined, washed sequentially with H2O (2 × 400 mL) and brine (1 × 400 mL), and dried with anhydrous MgSO4. After filtration, the filtrate was concentrated and the residue was purified by silica gel column chromatography to afford 4-bromo-2-methylquinoline (8.8 g, 36% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 7, p. 1865 - 1870
[2] Patent: US2003/229084, 2003, A1. Location in patent: Page/Page column 33
[3] Patent: WO2017/36404, 2017, A1. Location in patent: Page/Page column 130
[4] Patent: EP96214, 1991, B1
[5] European Journal of Medicinal Chemistry, 2013, vol. 69, p. 527 - 536

4-Bromo-2-methylquinoline Preparation Products And Raw materials

Raw materials

2-Methylquinoline 1-oxide 4-Hydroxy-2-methylquinoline

Preparation Products

4-Bromo-2-methylquinoline Suppliers

Global Suppliers ( 71)
Supplier Tel Email Country ProdList Advantage
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Shanghai yirong biology science and technology co., ltd 18049974220 3060526242@qq.com China 999 60
Chengdu Forest Science and Technology Development Co., Ltd. 18030648795 18030648795 sales@cdforestchem.com China 1998 58
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
Shanghai Run-Biotech Co., Ltd. 021-57171705 13817537615 sales@run-biotech.com China 2277 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai Worldyang Chemical Co.,Ltd. 021-56795766 sales@worldyachem.com China 9475 58
Chengdu Firster Pharmaceutical Co., Ltd. 028-87078428 028-87074958 chengzhenyong@cdfirster.com China 2580 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
Hangzhou J&H Chemical Co., Ltd. 0571-87396432 sales@jhechem.com China 14905 59
Supplier Advantage
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Shanghai yirong biology science and technology co., ltd 60
Chengdu Forest Science and Technology Development Co., Ltd. 58
Nanjing Norris-Pharm Technology Co., Ltd 55
Shanghai Run-Biotech Co., Ltd. 58
Bide Pharmatech Ltd. 60
Shanghai Worldyang Chemical Co.,Ltd. 58
Chengdu Firster Pharmaceutical Co., Ltd. 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55
Hangzhou J&H Chemical Co., Ltd. 59

View Latest Price from 4-Bromo-2-methylquinoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-BROMO-2-METHYLQUINOLINE pictures 2026-08-20 4-BROMO-2-METHYLQUINOLINE
50488-44-3
 $1.10 1g 99.0% Min 100 Tons Dideu Industries Group Limited

4-Bromo-2-methylquinoline Spectrum

4-BROMO-2-METHYLQUINOLINE(50488-44-3)1HNMR

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2-Methyl-4-broMoquinoline 4-Bromoquinaldine Quinoline, 4-bromo-2-methyl- 4-BROMO-2-METHYLQUINOLINE ISO 9001：2015 REACH 4-Bromo-2-methylquinoline 97%min 4-Bromo-2-methylquinoline 50488-44-3