2,8-Bis(trifluoromethyl)-4-bromoquinoline
- CAS No.
- 35853-45-3
- Chemical Name:
- 2,8-Bis(trifluoromethyl)-4-bromoquinoline
- Synonyms
- 2,8-BIS(TRIFL;)-4-BROMOQUINOL;1-METHYL-3-(AMINOMETHYL)PIPERIDINE;2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLIN;4-BROMO-2,8-BIS(TRIFLUOROMETHYL)QUINOLINE;2,8-Bis(trifluoromethyl)-4-bromoquinoline;Quinoline, 4-bromo-2,8-bis(trifluoromethyl)-;4-Bromo-2,8-bis(trifluoromethyl)quinoline, >=98%;2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE ISO 9001：2015 REACH
- CBNumber:
- CB7173196
- Molecular Formula:
- C11H4BrF6N
- Molecular Weight:
- 344.05
- MDL Number:
- MFCD00075340
- MOL File:
- 35853-45-3.mol
- MSDS File:
- SDS
| Melting point | 62-64 °C(lit.) |
|---|---|
| Boiling point | 281.6±35.0 °C(Predicted) |
| Density | 1.720±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Crystalline Powder |
| pka | -3.67±0.50(Predicted) |
| color | Off-white to yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-37/39 |
| WGK Germany | 3 |
| HS Code | 2933499090 |
2,8-Bis(trifluoromethyl)-4-bromoquinoline price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-B810378-50MG | 4-Bromo-2,8-bis(trifluoromethyl)quinoline | 35853-45-3 | 50mg | $59 | 2026-06-03 | Buy |
| TRC | TRC-B810378-500MG | 4-Bromo-2,8-bis(trifluoromethyl)quinoline | 35853-45-3 | 500mg | $129 | 2026-06-03 | Buy |
| TRC | TRC-B810378-100MG | 4-Bromo-2,8-bis(trifluoromethyl)quinoline | 35853-45-3 | 100mg | $72 | 2026-06-03 | Buy |
| Apolloscientific | PC407017 | 2,8-Bis(trifluoromethyl)-4-bromoquinoline >98% | 35853-45-3 | 250mg | $22 | 2026-06-04 | Buy |
| Apolloscientific | PC407017 | 2,8-Bis(trifluoromethyl)-4-bromoquinoline >98% | 35853-45-3 | 1g | $48 | 2026-06-04 | Buy |
2,8-Bis(trifluoromethyl)-4-bromoquinoline Chemical Properties, Uses, Production
Synthesis
35853-41-9
35853-45-3
Under argon protection, phosphorus bromide oxide (4 g, 14.2 mmol) was heated to 90 °C until the solid was completely dissolved. To this hot solution was added 2,8-bis(trifluoromethyl)-4-hydroxyquinoline (4.08 g, 14.2 mmol) and the temperature of the oil bath was raised to 150 °C. After 6 hours of reaction, the mixture was cooled to room temperature. The reaction was quenched by the addition of ice water and the resulting precipitate was filtered and washed with cold water to afford the target product 4-bromo-2,8-bis(trifluoromethyl)quinoline (4.70 g, 96% yield) as a white solid. Thin layer chromatography (TLC) Rf value was 0.79 (unfolding agent: cyclohexane/ether=5:1). Melting point: 60°C. 1H NMR (300 MHz, CDCl3) δ 7.82 (t, J=7.9 Hz, 1H), 8.11 (s, 1H), 8.22 (d, J=7.3 Hz, 1H), 8.46 (d, J=8.6 Hz, 1H). 13C NMR (125 MHz, CDCl3) δ 120.9 (q, J= 276.0 Hz), 122.0 (q, J=2.0 Hz), 123.6 (q, J=273.8 Hz), 128.9, 129.4, 129.8 (q, J=30.8 Hz), 130.5 (q, J=5.3 Hz), 131.5, 138.5, 144.5, 148.6 (q, J=36.1 Hz). Infrared spectra (IR) νmax: 1577, 1422, 1302, 1136, 1098, 1010, 876, 824 cm-1. gas chromatography-mass spectrometry (GC-MS) m/z: 343. high-resolution mass spectrometry (HRMS) calculated value of C11H4BrF6Na(M+Na)+: 365.9329, measured value: 365.9346.
References
[1] Angewandte Chemie - International Edition, 2015, vol. 54, # 47, p. 14070 - 14074
[2] Angew. Chem., 2015, vol. 127, # 47, p. 14276 - 14280,5
[3] Journal of Organic Chemistry, 2016, vol. 81, # 20, p. 9567 - 9575
[4] Tetrahedron Asymmetry, 2011, vol. 22, # 2, p. 138 - 148
[5] Patent: WO2012/107532, 2012, A1. Location in patent: Page/Page column 20-21
2,8-Bis(trifluoromethyl)-4-bromoquinoline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6740 | 52 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Quzhou Juhua Friendship Co., Ltd | 0570-3066667 | China | 3922 | 58 |
View Latest Price from 2,8-Bis(trifluoromethyl)-4-bromoquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE
35853-45-3
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2025-04-04 | 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE
35853-45-3
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-12-31 | 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE
35853-45-3
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE
35853-45-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE
35853-45-3
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2,8-BIS(TRIFLUOROMETHYL)-4-BROMOQUINOLINE
35853-45-3
- $1.00
- 99%
- Career Henan Chemical Co
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