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N-Acetyl-L-leucine

N-Acetyl-L-leucine Structure
N-Acetyl-L-leucine structure
CAS No.
1188-21-2
Chemical Name:
N-Acetyl-L-leucine
Synonyms
AC-LEU-OH;Levacetylleucine;ACETYL-L-LEUCINE;ACETYL-DL-LEUCINE;AC-DL-LEU-OH;N-Ac-L-Leu-OH;(S)-2-AcetaMido-4-Methylpentanoic acid;Ac-L-Leu-OH;n-acetyl-l-leucin;(S)-N-Acetylleucine
CBNumber:
CB9852903
Molecular Formula:
C8H15NO3
Molecular Weight:
173.21
MDL Number:
MFCD00065131
MOL File:
1188-21-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-07 18:09:57
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N-Acetyl-L-leucine Properties

Melting point 187-190 °C(lit.)
alpha -24.5 º (c=4, MeOH)
Boiling point 303.86°C (rough estimate)
Density 1.1599 (rough estimate)
refractive index -22 ° (C=5, EtOH)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Ethanol (Slightly), Water (Slightly, Heated)
pka 3.67±0.10(Predicted)
form Crystalline Powder
color White
optical activity [α]25/D 23±3°, c = 2 in ethanol
Water Solubility 0.81 g/100 mL (20 ºC)
BRN 1724849
Major Application peptide synthesis
InChI 1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)/t7-/m0/s1
InChIKey WXNXCEHXYPACJF-ZETCQYMHSA-N
SMILES CC(C)C[C@H](NC(C)=O)C(O)=O
CAS DataBase Reference 1188-21-2(CAS DataBase Reference)
FDA UNII E915HL7K2O
NIST Chemistry Reference L-leucine, n-acetyl-(1188-21-2)
EPA Substance Registry System L-Leucine, N-acetyl- (1188-21-2)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319-H315-H335
Precautionary statements  P271-P261-P280
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36-26
WGK Germany  3
TSCA  TSCA listed
HazardClass  IRRITANT
HS Code  29241900
Storage Class 11 - Combustible Solids
NFPA 704
1
0 0

N-Acetyl-L-leucine price More Price(82)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 441511 N-Acetyl-L-leucine ReagentPlus , 99% 1188-21-2 25g $118 2026-04-30 Buy
TCI Chemical A0098 N-Acetyl-L-leucine >99.0%(T) 1188-21-2 5g $34 2026-04-30 Buy
TCI Chemical A0098 N-Acetyl-L-leucine >99.0%(T) 1188-21-2 25g $73 2026-04-30 Buy
Cayman Chemical 42889 N-acetyl-L-Leucine ≥98% 1188-21-2 10g $50 2026-04-30 Buy
Cayman Chemical 42889 N-acetyl-L-Leucine ≥98% 1188-21-2 25g $118 2026-04-30 Buy
Product number Packaging Price Buy
441511 25g $118 Buy
A0098 5g $34 Buy
A0098 25g $73 Buy
42889 10g $50 Buy
42889 25g $118 Buy

N-Acetyl-L-leucine Chemical Properties,Uses,Production

Preparation

Add 2 mol of leucine, 3-3.5 mol of p-chloroacetanilide, and 3-4 mol of phenylacetyl to the reaction vessel. Raise the solution temperature to 60-65℃, reflux for 80-110 min, let stand for 2-3 h, lower the solution temperature to 10-15℃, cool and crystallize, filter the crystals, wash with potassium bromide solution, wash with triethylamine solution, wash with nitromethane solution, and dehydrate with a dehydrating agent to obtain the product N-acetyl-L-leucine.

Chemical Properties

White crystalline powder

Uses

N-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo.

Definition

ChEBI: The N-acetyl derivative of L-leucine.

reaction suitability

reaction type: C-H Activation
reaction type: solution phase peptide synthesis
reagent type: catalyst
reaction type: Peptide Synthesis

Pharmaceutical Applications

N-acetyl-l-leucine (NALL) has shown therapeutic potential for neurodegenerative diseases, including in prodromal stages of Parkinson's disease (PD). Researches show that the therapeutic potential of NALL for PD by its protective effects on α-synuclein pathology and synaptic function in vulnerable dopaminergic neurons[1].

in vivo

Levacetylleucine (60 mg/kg, i.v., administration on days 1, 2 and 3 for 15 days) decreases the postural imbalance scores and accelerates the course of postural compensation induced by UL in rats[3].
Levacetylleucine (100 mg/kg, oral gavage, administration daily for 28 days) attenuates cortical cell death afer traumatic brain injury (TBI) in N-Acetyl-L-leucine-treated TBI mouse cortices[4].

Animal Model:Male Sprague-Dawley rats (mean 400±20 g, age 3 months) after chemical UL[3]
Dosage:60 mg/kg
Administration:i.v., 15 days
Result:Significantly decreased the postural imbalance scores on 7 day and accelerated the course of postural compensation by about 6 days in rats.
Animal Model:C57/BL6 mice[4]
Dosage:100 mg/kg
Administration:oral gavage, administration daily for 1-28 days
Result:Did not afect food intake and body weight in mice.
Animal Model:N-Acetyl-L-leucine-treated TBI mouse cortices[4]
Dosage:100 mg/kg
Administration:oral gavage, administration daily for 28 days
Result:Prevented cortical cell death which peaks at early time points (day 1) afer TBI in N-Acetyl-L-leucine-treated TBI mouse cortices.

IC 50

Human Endogenous Metabolite

References

[1] Song, P., Chen, C., Franchini, R., Duong, B., Wang, Y.-Z., Coukos, R., Xie, Z., Savas, J. N., Zhou, Y., Bertoldi, M., Surmeier, D. J., Parisiadou, L., & Krainc, D. (2026). N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in Parkinson's disease models. Journal of Clinical Investigation, 136 5. https://doi.org/10.1172/JCI196137

N-Acetyl-L-leucine synthesis

18869-43-7
1188-21-2
Synthesis of N-Acetyl-L-leucine from methyl leucinate hydrochloride

N-Acetyl-L-leucine Preparation Products And Raw materials

Raw materials

Acetic anhydride Methanol Sodium hydroxide L-Leucine

Preparation Products

N-Acetyl-L-leucine Suppliers

Global( 645)Suppliers
Supplier Tel Email Country ProdList Advantage
Taian Jiayue Bio-chemical Co. LTD 15318151873 285424065@qq.com China 4541 58
Gansu Province Baishixing Pharmaceutical Co.,Ltd 15008395229 15008395229 zhangqing@gs-bsx.com China 50 58
Shanghai Chiral Chemicals Inc. 021-37285021 13472570865 tym7xi@aliyun.com China 299 64
Sichuan Tongsheng Amino acids Co.,Ltd. 0838-2274206 17340404235 sales@biots.cn China 300 66
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
Taian Jiayue Bio-chemical Co. LTD 58
Gansu Province Baishixing Pharmaceutical Co.,Ltd 58
Shanghai Chiral Chemicals Inc. 64
Sichuan Tongsheng Amino acids Co.,Ltd. 66
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61

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View Lastest Price from N-Acetyl-L-leucine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Acetyl-L-leucine pictures 2026-09-11 N-Acetyl-L-leucine
1188-21-2
 0.99 RongNa Biotechnology Co.,Ltd
N-Acetyl-L-leucine pictures 2026-09-11 N-Acetyl-L-leucine
1188-21-2
 1kg 97.5%-102.5%; AJI 20 TONS WUHAN FORTUNA CHEMICAL CO., LTD
Ac-L-Leu-OH pictures 2026-09-11 Ac-L-Leu-OH
1188-21-2
 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
  • Ac-L-Leu-OH pictures
  • Ac-L-Leu-OH
    1188-21-2
  • 98%
  • Sichuan HongRi Pharma-Tech Co.,Ltd

N-Acetyl-L-leucine Spectrum

N-Acetyl-L-leucine(1188-21-2)MSN-Acetyl-L-leucine(1188-21-2)1HNMRN-Acetyl-L-leucine(1188-21-2)13CNMRN-Acetyl-L-leucine(1188-21-2)IR1N-Acetyl-L-leucine(1188-21-2)IR2N-Acetyl-L-leucine(1188-21-2)Raman

1188-21-2(N-Acetyl-L-leucine)Related Search:

N-L-gamma-Glutamyl-L-leucine HIPPURYL-HIS-LEU N-Glycyl-L-leucine N-(3-Indolylacetyl)-L-leucine, Indole-3-acetyl-L-leucine, 99%,INDOLE-3-ACETYL-L-LEUCINE (R)-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline N-acetyl-L-leucine
L-Leucine DL-Leucine N-Acetyl-D-leucine Acetylleucine THR-VAL-LEU
H-PHE-LEU-OH Z-ALA-LEU-OH H-TRP-LEU-OH H-MET-LEU-OH H-HIS-LEU-OH
N-CBZ-LEU-LEU METHYL ESTER ACETYL-L-LEUCINE METHYL ESTER,N-ALPHA-ACETYL-L-LEUCINE METHYL ESTER,N-Acetyl-L-leucine methyl ester H-TYR-LEU-OH

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AKOS BBS-00004735 ACETYL-DL-LEUCINE, N- AC-LEUCINE IFLAB-BB F0777-0821 N-ALPHA-ACETYL-L-LEUCINE N-ALPHA-ACETYL-DL-LEUCINE N-ACETYL LEUCINE N-ACETYL-L-LEUCINE N-ACETYL-DL-LEU (S)-N-Acetylleucine (S)-2-ACETYLAMINO-4-METHYL-PENTANOIC ACID (2S)-2-(Acetylamino)-4-methylpentanoic acid N-Acetyl-L-leucine, 99% 25GR N-Acetyl-L-leucine, 99.0%(T) N-Acetyl-L-leucine ReagentPlus(R), 99% N-Acetyl-L-leucine Vetec(TM) reagent grade, 98% N-Acetyl-L(DL)-Leucine N-ACETYL-L-LEUCINE CRYSTALLINE N-ACETYLE-L-LEUCINE N-Acetyl-L-Leu-OH (2S)-N-ACETYL-L-LEUCINE Ac-L-Leu-OH Leucine, N-acetyl-, L- L-Leucine, N-acetyl- N-Acetyl-L-lenucine N-Ac-DL-Leucine N-Acetyl-L-leucine,99% (S)-Ac-2-amino-4-methyl-pentanoic acid Acetyl-L-leucine≥ 99% (Assay) N-Acetyl-L-leucine in stock GMP Factory N-Acetyl-L-leucine > N-Acetyl-L-leucine USP/EP/BP N-Acetyl-L-Leucine extrapure, 99% N-Acdtyl-L-Leucine N-Acetyl-L-leucine, 10 mM in DMSO N-Acetyl-L-leucine N-Acetyl-L-leucine, 98% ACETYL-DL-LEUCINE N-Ac-L-Leu-OH (S)-2-AcetaMido-4-Methylpentanoic acid AC-DL-LEU-OH ACETYL-L-LEUCINE AC-LEU-OH Levacetylleucine n-acetyl-l-leucin AC-Leu 1188-21-2 CH32CHCH2CHNHCOCH3CO2H CARBOXYLIC ACID Modified Amino Acids Amino Acids and Peptides Biochemicals and Reagents BioChemical A - H Amino Acid Derivatives Leucine Peptide Synthesis Specialty Synthesis