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N-Acetyl-L-leucine

N-Acetyl-L-leucine structure

CAS No.: 1188-21-2

Chemical Name:: N-Acetyl-L-leucine

Synonyms: AC-LEU-OH;ACETYL-DL-LEUCINE;ACETYL-L-LEUCINE;AC-DL-LEU-OH;N-Ac-L-Leu-OH;Ac-L-Leu-OH;(S)-N-Acetylleucine;(S)-2-AcetaMido-4-Methylpentanoic acid;AC-LEUCINE;N-ACETYL-DL-LEU

CBNumber:: CB9852903

Molecular Formula:: C8H15NO3

Molecular Weight:: 173.21

MDL Number:: MFCD00065131

MOL File:: 1188-21-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-15 07:54:27

Product description	Number	Pack Size	Price
N-Acetyl-L-leucine ReagentPlus , 99%	441511	25g	$118
N-Acetyl-L-leucine >99.0%(T)	A0098	5g	$34
N-Acetyl-L-leucine >99.0%(T)	A0098	25g	$73
N-acetyl-L-Leucine ≥98%	42889	10g	$50
N-acetyl-L-Leucine ≥98%	42889	25g	$118
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N-Acetyl-L-leucine Properties

Melting point	187-190 °C(lit.)
alpha	-24.5 º (c=4, MeOH)
Boiling point	303.86°C (rough estimate)
Density	1.1599 (rough estimate)
refractive index	-22 ° (C=5, EtOH)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Ethanol (Slightly), Water (Slightly, Heated)
form	Crystalline Powder
pka	3.67±0.10(Predicted)
color	White
optical activity	[α]25/D 23±3°, c = 2 in ethanol
Water Solubility	0.81 g/100 mL (20 ºC)
BRN	1724849
Major Application	peptide synthesis
InChI	1S/C8H15NO3/c1-5(2)4-7(8(11)12)9-6(3)10/h5,7H,4H2,1-3H3,(H,9,10)(H,11,12)/t7-/m0/s1
InChIKey	WXNXCEHXYPACJF-ZETCQYMHSA-N
SMILES	CC(C)C[C@H](NC(C)=O)C(O)=O
CAS DataBase Reference	1188-21-2(CAS DataBase Reference)
FDA UNII	E915HL7K2O
NIST Chemistry Reference	L-leucine, n-acetyl-(1188-21-2)
EPA Substance Registry System	L-Leucine, N-acetyl- (1188-21-2)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319-H315-H335

Precautionary statements

P271-P261-P280

Hazard Codes

Risk Statements

36/37/38

Safety Statements

24/25-36-26

WGK Germany

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29241900

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

N-Acetyl-L-leucine price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	441511	N-Acetyl-L-leucine ReagentPlus , 99%	1188-21-2	25g	$118	2026-04-30	Buy
TCI Chemical	A0098	N-Acetyl-L-leucine >99.0%(T)	1188-21-2	5g	$34	2026-04-30	Buy
TCI Chemical	A0098	N-Acetyl-L-leucine >99.0%(T)	1188-21-2	25g	$73	2026-04-30	Buy
Cayman Chemical	42889	N-acetyl-L-Leucine ≥98%	1188-21-2	10g	$50	2026-04-30	Buy
Cayman Chemical	42889	N-acetyl-L-Leucine ≥98%	1188-21-2	25g	$118	2026-04-30	Buy

Product number	Packaging	Price	Buy
441511	25g	$118	Buy
A0098	5g	$34	Buy
A0098	25g	$73	Buy
42889	10g	$50	Buy
42889	25g	$118	Buy

N-Acetyl-L-leucine Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder

Uses

N-Acetyl-L-(-)-leucine is used in the preparation of small molecule inhibitors of anti-apoptotic Bcl-2 family proteins. Also used in the preparation of amphiphilic copolymers involving hydrophobic amino acid and oligopeptide side chains for optical tumor imaging in vivo.

Definition

ChEBI: The N-acetyl derivative of L-leucine.

reaction suitability

reaction type: C-H Activation
reaction type: solution phase peptide synthesis
reagent type: catalyst
reaction type: Peptide Synthesis

in vivo

Levacetylleucine (60 mg/kg, i.v., administration on days 1, 2 and 3 for 15 days) decreases the postural imbalance scores and accelerates the course of postural compensation induced by UL in rats^[3].
Levacetylleucine (100 mg/kg, oral gavage, administration daily for 28 days) attenuates cortical cell death afer traumatic brain injury (TBI) in N-Acetyl-L-leucine-treated TBI mouse cortices^[4].

Animal Model:	Male Sprague-Dawley rats (mean 400±20 g, age 3 months) after chemical UL^[3]
Dosage:	60 mg/kg
Administration:	i.v., 15 days
Result:	Significantly decreased the postural imbalance scores on 7 day and accelerated the course of postural compensation by about 6 days in rats.

Animal Model:	C57/BL6 mice^[4]
Dosage:	100 mg/kg
Administration:	oral gavage, administration daily for 1-28 days
Result:	Did not afect food intake and body weight in mice.

Animal Model:	N-Acetyl-L-leucine-treated TBI mouse cortices^[4]
Dosage:	100 mg/kg
Administration:	oral gavage, administration daily for 28 days
Result:	Prevented cortical cell death which peaks at early time points (day 1) afer TBI in N-Acetyl-L-leucine-treated TBI mouse cortices.

IC 50

Human Endogenous Metabolite

N-Acetyl-L-leucine synthesis

Synthesis of N-Acetyl-L-leucine from methyl leucinate hydrochloride

N-Acetyl-L-leucine Preparation Products And Raw materials

Raw materials

Acetic anhydride Methanol Sodium hydroxide L-Leucine

Preparation Products

N-Acetyl-L-leucine Suppliers

Global( 631)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
DONBOO AMINO ACID COMPANY	+8618051385538	donboo@donboo.com	China	9363	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33324	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Wuhan Fortuna Chemical Co., Ltd	+86-27-59207850	info@fortunachem.com	China	5973	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5235	58
Sichuan HongRi Pharma-Tech Co.,Ltd	+8618382028708	ni@enlaibio.com	China	1100	58
airuikechemical co., ltd.	+86-18353166132	sales02@airuikechemical.com	China	983	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	+15184799099	lbaochemicals@gmail.com	China	671	58
Nantong Provichem Biotech Co., Ltd.	+8617505220108	sales@provichem.cn	China	34	58

Supplier	Advantage
DONBOO AMINO ACID COMPANY	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Hebei Yanxi Chemical Co., Ltd.	58
Wuhan Fortuna Chemical Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Sichuan HongRi Pharma-Tech Co.,Ltd	58
airuikechemical co., ltd.	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	58
Nantong Provichem Biotech Co., Ltd.	58

The application research of N-acetyl-L-leucine in Niemann–Pick Disease Type C
This report introduced the mechanism and the safety and efficacy of N-acetyl-l-leucine for the treatment of Niemann-Pick disea....
Nov 18，2025

View Lastest Price from N-Acetyl-L-leucine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-17	N-Acetyl-L-leucine 1188-21-2			0.99		RongNa Biotechnology Co.,Ltd
2026-05-15	N-Acetyl-L-leucine 1188-21-2	US $0.00-0.00 / kg	1kg	97.5%-102.5%; AJI	20 TONS	WUHAN FORTUNA CHEMICAL CO., LTD
2026-05-15	N-Acetyl-L-leucine 1188-21-2	US $10.00-10.00 / kg	1kg	97.50%～102. 50%	20 tons	Nantong Provichem Biotech Co., Ltd.

N-Acetyl-L-leucine
1188-21-2
0.99
RongNa Biotechnology Co.,Ltd

N-Acetyl-L-leucine
1188-21-2
US $0.00-0.00 / kg
97.5%-102.5%; AJI
WUHAN FORTUNA CHEMICAL CO., LTD

N-Acetyl-L-leucine
1188-21-2
US $10.00-10.00 / kg
97.50%～102. 50%
Nantong Provichem Biotech Co., Ltd.

N-Acetyl-L-leucine Spectrum

N-Acetyl-L-leucine(1188-21-2)MS N-Acetyl-L-leucine(1188-21-2)¹HNMR N-Acetyl-L-leucine(1188-21-2)¹³CNMR N-Acetyl-L-leucine(1188-21-2)IR1 N-Acetyl-L-leucine(1188-21-2)IR2 N-Acetyl-L-leucine(1188-21-2)Raman

1188-21-2(N-Acetyl-L-leucine)Related Search:

N-L-gamma-Glutamyl-L-leucine HIPPURYL-HIS-LEU N-Glycyl-L-leucine ACETYL-D-LEUCINE,N-ALPHA-ACETYL-D-LEUCINE,N-ACETYL-D-LEUCINE,N-ACETYL-L-LEUCINE:AC-D-LEU-OH ACETYL-DL-LEUCINE,N-ALPHA-ACETYL-DL-LEUCINE,N-ACETYL-DL-LEUCINE,ACETYL-DL-LEUCINE, N-

N-(3-Indolylacetyl)-L-leucine, Indole-3-acetyl-L-leucine, 99%,INDOLE-3-ACETYL-L-LEUCINE (R)-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline N-acetyl-L-leucine L-Leucine DL-Leucine THR-VAL-LEU

H-PHE-LEU-OH Z-ALA-LEU-OH H-TRP-LEU-OH H-MET-LEU-OH H-HIS-LEU-OH

N-CBZ-LEU-LEU METHYL ESTER ACETYL-L-LEUCINE METHYL ESTER,N-ALPHA-ACETYL-L-LEUCINE METHYL ESTER,N-Acetyl-L-leucine methyl ester H-TYR-LEU-OH

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AKOS BBS-00004735 ACETYL-DL-LEUCINE, N- AC-LEUCINE IFLAB-BB F0777-0821 N-ALPHA-ACETYL-L-LEUCINE N-ALPHA-ACETYL-DL-LEUCINE N-ACETYL LEUCINE N-ACETYL-L-LEUCINE N-ACETYL-DL-LEU (S)-N-Acetylleucine (S)-2-ACETYLAMINO-4-METHYL-PENTANOIC ACID (2S)-2-(Acetylamino)-4-methylpentanoic acid N-Acetyl-L-leucine, 99% 25GR (S)-2-AcetaMido-4-Methylpentanoic acid N-Acetyl-L-leucine, 99.0%(T) N-Acetyl-L-leucine ReagentPlus(R), 99% N-Acetyl-L-leucine Vetec(TM) reagent grade, 98% N-Acetyl-L(DL)-Leucine N-ACETYL-L-LEUCINE CRYSTALLINE N-ACETYLE-L-LEUCINE N-Acetyl-L-Leu-OH (2S)-N-ACETYL-L-LEUCINE Ac-L-Leu-OH Leucine, N-acetyl-, L- L-Leucine, N-acetyl- N-Acetyl-L-lenucine n-acetyl-l-leucin N-Ac-DL-Leucine N-Acetyl-L-leucine,99% (S)-Ac-2-amino-4-methyl-pentanoic acid Acetyl-L-leucine≥ 99% (Assay) N-Acetyl-L-leucine in stock GMP Factory N-Acetyl-L-leucine > N-Acetyl-L-leucine USP/EP/BP N-Acetyl-L-Leucine extrapure, 99% N-Acdtyl-L-Leucine N-Acetyl-L-leucine, 10 mM in DMSO Levacetylleucine N-Acetyl-L-leucine N-Acetyl-L-leucine, 98% ACETYL-DL-LEUCINE ACETYL-L-LEUCINE AC-DL-LEU-OH AC-LEU-OH N-Ac-L-Leu-OH 1188-21-2 CH32CHCH2CHNHCOCH3CO2H CARBOXYLIC ACID Modified Amino Acids Amino Acids and Peptides Biochemicals and Reagents BioChemical A - H Amino Acid Derivatives Leucine Peptide Synthesis Specialty Synthesis N-Acetyl-Amino acid series